Article
Biotechnology & Applied Microbiology
Boksoon Chang, In Kyung Hwang, Seung Hyeun Lee
Summary: Elevated serum Romo1 levels were significantly associated with early recurrence in patients with lung adenocarcinoma treated with surgical resection. Combination with CEA levels could result in a higher predictive value for disease-free survival.
ONCOTARGETS AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Joanna Nowaczyk, Barbara Poniedzialek, Piotr Rzymski, Dominika Sikora, Mariola Ropacka-Lesiak
Summary: This study aimed to evaluate platelet parameters in pregnant women with fetal growth restriction (FGR) and their relationship with hemodynamic abnormalities. The study found that FGR patients had impaired oxidative metabolism in platelets, which may lead to oxidative stress and impaired platelet function.
Article
Clinical Neurology
Moinay Kim, Joonho Byun, Yeongu Chung, Si Un Lee, Ji Eun Park, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
Summary: Administering ROS scavengers to patients with acute ICH significantly reduced PHE volume, shortened time to reach target Richmond Agitation Sedation Scale, and reduced length of stay in the intensive care unit.
Article
Biochemistry & Molecular Biology
Chinmay Pal
Summary: This review provides a comprehensive exploration of redox modulation as an effective anticancer therapy, exploring the mechanisms by which anticancer compounds disrupt cancer cell proliferation and survival by perturbing redox equilibrium. It also examines the challenges and potential side effects of redox-based treatments, as well as the development of novel redox-targeted agents.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Biochemistry & Molecular Biology
Anton G. Rogov, Tatiana N. Goleva, Khoren K. Epremyan, Igor I. Kireev, Renata A. Zvyagilskaya
Summary: Mitochondria are considered the primary source of ROS in cells, with ROS-induced ROS release triggered in cardiac myocytes under excessive oxidative stress. Using Dipodascus magnusii yeast cells, it was found that prooxidant-induced oxidative stress begins in mitochondria before spreading to the whole cell, with mitochondrial ROS leading to mitochondrial fragmentation.
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Yoon-Seok Seo, Jung-Min Park, Jae-Hyeong Kim, Moo-Yeol Lee
Summary: Smoking is a significant risk factor for various diseases due to the production of excessive reactive oxygen species (ROS). This review focuses on how cigarette smoke promotes the formation of ROS and provides key mechanisms involved.
Article
Engineering, Environmental
Steven Lelieveld, Jake Wilson, Eleni Dovrou, Ashmi Mishra, Pascale S. J. Lakey, Manabu Shiraiwa, Ulrich Poeschl, Thomas Berkemeier
Summary: Air pollutants such as aerosols and ozone can cause the generation of reactive oxygen species in the human respiratory tract, leading to oxidative stress and adverse health effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Oncology
Jia-Yi Qian, Yun Hao, Hai-Hong Yu, Lei-Lei Wu, Zhi-Yuan Liu, Qiao Peng, Zhi-Xin Li, Kun Li, Yu'e Liu, Rang-Rang Wang, Dong Xie
Summary: This study aimed to construct an effective nomogram based on clinical and oxidative stress-related characteristics to predict the prognosis of stage I lung adenocarcinoma (LUAD). A retrospective study was performed on 955 eligible patients and SOS was established as an independent prognostic factor for stage I LUADs. The constructed nomogram based on SOS accurately predicted the survival of those patients with a high concordance index.
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama, Shubhadeep Roychoudhury
Summary: Reactive nitrogen species (RNS) play important roles in male reproduction, but excessive levels can impair fertility by affecting testicular functions and compromising semen quality. High RNS levels lead to abnormalities in germ cells and gametes, and severely impact maturation and fertilization processes. Conventional semen analyses are not reliable predictors for assisted reproductive technology outcomes in cases of male infertility, highlighting the need for novel assessment and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Prima Buranasin, Hiromi Kominato, Koji Mizutani, Risako Mikami, Natsumi Saito, Kohei Takeda, Takanori Iwata
Summary: Diabetes mellitus is associated with periodontal disease and affects the efficacy of periodontal treatment. Increased reactive oxygen species (ROS) production in periodontal tissues of diabetic patients contributes to insulin resistance and impairs wound healing and tissue repair. Antioxidants and insulin resistance ameliorants may improve wound healing by inhibiting ROS production. This review comprehensively examines the latest evidence on ROS generation in periodontal tissues, particularly related to microbial challenge and diabetes, and discusses the impact of oxidative stress on wound healing in periodontal and dental implant therapies, as well as the potential benefits of administering antioxidants and anti-insulin resistance medications to counteract ROS production and inflammation.
Article
Oncology
Parneet Cheema, Byoung Chul Cho, Helano Freitas, Mariano Provencio, Yuh Min Chen, Sang-We Kim, Yi-Long Wu, Antonio Passaro, Claudio Martin, Marcello Tiseo, Gee-Chen Chang, Keunchil Park, Benjamin Solomon, Otto Burghuber, Janessa Laskin, Ziping Wang, Sung Yong Lee, Yanping Hu, Johan Vansteenkiste, He-long Zhang, Emer Hanrahan, Thomas Geldart, Rosemary Taylor, Leslie Servidio, Jingyi Li, Filippo de Marinis
Summary: This study reports the final analysis from ASTRIS, the largest real-world study of osimertinib in patients with advanced/metastatic EGFR T790M NSCLC. The results demonstrate the clinical benefit and safety of osimertinib in this patient population.
Article
Oncology
Cheol-Kyu Park, Hyung-Joo Oh, Young-Chul Kim, Yong-Hyub Kim, Sung-Ja Ahn, Won Gi Jeong, Jeong Yeop Lee, Jae Cheol Lee, Chang Min Choi, Wonjun Ji, Si Yeol Song, Juwhan Choi, Sung Yong Lee, Hakyoung Kim, Shin Yup Lee, Jongmoo Park, Seong Hoon Yoon, Ji Hyeon Joo, In-Jae Oh
Summary: This study aimed to investigate the efficacy and safety of durvalumab consolidation (DC) after chemoradiotherapy (CRT) in patients with unresectable stage III NSCLC. The results showed that durvalumab could prolong progression-free survival (rwPFS) and overall survival, but could also cause radiation pneumonitis and immune-related adverse events.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Substance Abuse
Jihye Lee, Saerom Lee, Woncheol Lee, Seung Hyeun Lee, Won Gun Kwack, Young Joong Kang
Summary: This study investigated the knowledge of smoking hazards and perceptions of smoking cessation methods among occupational health nurses (OHNs) in South Korea. The results showed that the majority of the nurses underestimated the association between smoking and lung cancer, chronic obstructive pulmonary disease, and mortality. They also perceived themselves as lacking competence in smoking cessation counseling. Therefore, it is necessary to enhance the knowledge, skills, and competence of OHNs in smoking cessation interventions.
TOBACCO INDUCED DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Seungmin Kim, Byeong Hyeon Choi, Hyunku Shin, Kihun Kwon, Sung Yong Lee, Hyun Bin Yoon, Hyun Koo Kim, Yeonho Choi
Summary: Protein mutation detection using liquid biopsy can be performed periodically to rapidly detect newly emerging mutations. However, it has low diagnostic accuracy due to the abundance of normal proteins in body fluids. To increase accuracy, plasma exosomes were analyzed using nanoplasmonic spectra and deep learning. Mutated exosomal proteins with subtle structural changes were detected using Raman spectra, and a deep-learning classification algorithm achieved high accuracy in distinguishing patients with EGFR mutations from controls. This technique holds promise for companion diagnostics and treatment monitoring.
Article
Cell Biology
Cheol-Kyu Park, Ha Ra Jun, Hyung-Joo Oh, Ji-Young Lee, Hyun-Ju Cho, Young-Chul Kim, Jeong Eun Lee, Seong Hoon Yoon, Chang Min Choi, Jae Cheol Lee, Sung Yong Lee, Shin Yup Lee, Sung-Min Chun, In-Jae Oh
Summary: This study aimed to investigate the feasibility of blood-based biomarkers, including blood tumor mutation burden (bTMB), to predict atezolizumab efficacy in relapsed and advanced non-small cell lung cancer (NSCLC). The results suggest that baseline levels and dynamic changes of blood-based biomarkers can predict atezolizumab efficacy in previously treated NSCLC patients.
Article
Infectious Diseases
Bo-Guen Kim, Danbee Kang, Kyung Hoon Min, Juhee Cho, Kyeongman Jeon
Summary: The comparative analysis of clinical outcomes in patients with hospital-acquired pneumonia treated with cefepime and piperacillin/tazobactam showed that the treatment effects were comparable between the two groups.
Article
Engineering, Civil
Soonho Kim, Yun Sik Jang, Taekgeun Oh, Seung Kyun Lee, Doo-Yeol Yoo
Summary: With the increasing use of wireless electronic devices, electromagnetic pollution has become a serious threat. This study investigates the advantages of adding carbon fibers to strain-hardening cementitious composites (SHCCs) to enhance their mechanical and electrical properties as electromagnetic shielding materials. The results show that the addition of carbon fibers improves the tensile performance, energy absorption capacity, electrical conductivity, and EMI shielding effectiveness of the SHCCs. This study provides a basis for evaluating the EMI shielding effectiveness of damaged structures.
ARCHIVES OF CIVIL AND MECHANICAL ENGINEERING
(2023)
Article
Ethics
Ae-Rin Baek, Sang-Bum Hong, Soohyun Bae, Hye Kyeong Park, Changhwan Kim, Hyun-Kyung Lee, Woo Hyun Cho, Jin Hyoung Kim, Youjin Chang, Heung Bum Lee, Hyun-Il Gil, Beomsu Shin, Kwang Ha Yoo, Jae Young Moon, Jee Youn Oh, Kyung Hoon Min, Kyeongman Jeon, Moon Seong Baek, Korean HAP VAP Study Grp
Summary: This study aimed to investigate end-of-life (EOL) decisions in patients with hospital-acquired pneumonia (HAP) in Korea. The results showed that despite the enforcement of the Life-Sustaining Treatment (LST) Decision Act, do-not-resuscitate (DNR) orders were still common. Additionally, there was a correlation between patient age and decision type. Therefore, advance care planning for patients with HAP is necessary.
BMC MEDICAL ETHICS
(2023)
Article
Construction & Building Technology
Gi Woong Kim, Taekgeun Oh, Seung Kyun Lee, Seung Won Lee, Nemkumar Banthia, Eunjong Yu, Doo-Yeol Yoo
Summary: The effects of steel and polyethylene (PE) fiber hybrid reinforcement on the mechanical performance of cementless ultra-high performance alkali-activated concrete (UHP-AAC) were studied. The compressive and tensile strengths were reduced when steel fibers were replaced with PE fibers. The best performance was observed in the hybrid specimens with a medium-grade fine aggregate-to-binder (FA/B) ratio.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Construction & Building Technology
Rongzhen Piao, Taekgeun Oh, Gi Woong Kim, Hong-Joon Choi, Nemkumar Banthia, Doo- Yeol Yoo
Summary: This study investigates the effect of silicon dioxide nanoparticles (nano-SiO2) on the microstructure and mechanical properties of eco-friendly, cementless ultra-high-performance fiber-reinforced alkali-activated concrete (UHP-FRAAC). The results showed that the addition of nano-SiO2 improves the packing density of UHP-AAC and generates abundant C-(A-)S-H gels to increase its density. The optimal dosage of nano-SiO2 in UHP-FRAAC was suggested to be 2% by mass of silica fume.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Construction & Building Technology
Booki Chun, Taekgeun Oh, Hong-Joon Choi, Seung Kyun Lee, Nemkumar Banthia, Doo-Yeol Yoo
Summary: This study investigates the self-healing capacity of ultra-rapid-hardening fiber-reinforced cementitious composites. Different lengths of polyethylene (PE) fibers were incorporated with different volume fractions. The fiber reinforcing index was proportional to the tensile performance, with the length of the PE fiber being more dominant. Specimens with 2% medium-length fibers showed the most appropriate self-healing behavior.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Oncology
Jehun Kim, Tae Won Jang, Chang Min Choi, Mi Hyun Kim, Sung Yong Lee, Cheol Kyu Park, Yoon Soo Chang, Kye Young Lee, Seung Joon Kim, Sei Hoon Yang, Jeong Seon Ryu, Jeong Eun Lee, Shin Yup Lee, Chan Kwon Park, Sang Hoon Lee, Seung Hun Jang, Seong Hoon Yoon
Summary: This study aimed to identify prognostic factors for brain metastases (BMs) in non-small cell lung cancer (NSCLC) patients and evaluate the treatment outcomes of first-line afatinib in patients with EGFR-mutant NSCLC and BM in a real-world setting. CNS failure was found to be a poor prognostic factor for time on treatment (TOT) and overall survival (OS), correlated with younger age, poor performance status, higher metastatic number, advanced disease, uncommon EGFR mutations, and baseline liver and/or bone metastases.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Construction & Building Technology
Joo Ha Lee, Doo-Yeol Yoo
Summary: This study aims to design a high-performance fiber-reinforced cementitious composite (HPFRCC) material for reinforcing masonry walls and assess its impact on in-plane shear performance. The study found that HPFRCC significantly enhances the shear strength and energy dissipation capacity of masonry walls.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Construction & Building Technology
Gi Woong Kim, Taekgeun Oh, Booki Chun, Seung Won Lee, Chung-Chan Hung, Doo-Yeol Yoo
Summary: By modifying the surface of steel fibers with an EDTA-electrolyte solution, the mechanical performance of UHP-AAC was improved, leading to higher fiber bond strength and tensile strength. The best tensile performance was achieved when straight steel fibers were surface-refined by the EDTA-electrolyte solution for 6 hours. The Weibull distribution model was used to predict crack width, and it was found that the surface treatment using EDTA solution had marginal influence on the median microcrack width of UHP-AAC, while straight and twisted fibers produced wider cracks.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Construction & Building Technology
Jiale Zhou, Peng Yu, Doo-Yeol Yoo, Lie Yu, Lu Ke
Summary: This study investigates the effect of different types of stirrup and cross-sectional dimensions on the torsional behaviors of ultra-high-performance fiber-reinforced concrete hollow beams. The results show that the inclusion of flanges substantially influences the torsional strength of the beams, attributed to the section torsional plastic resistance moment and UHPFRC tensile capacity in flanges.
DEVELOPMENTS IN THE BUILT ENVIRONMENT
(2023)