Review
Pharmacology & Pharmacy
Cristina Estornut, Javier Milara, Maria Amparo Bayarri, Nada Belhadj, Julio Cortijo
Summary: This review discusses the role of oxidative stress in the development and progression of IPF, the underlying mechanisms, and the evidence of oxidative stress in human IPF. It also analyzes the mechanism of action, efficacy, and current status of different drugs developed to inhibit oxidative stress as anti-fibrotic therapy in IPF.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Patrudu Makena, Tatiana Kikalova, Gaddamanugu L. L. Prasad, Sarah A. A. Baxter
Summary: Lung fibrosis is a progressive fatal disease caused by deregulated wound healing of lung epithelial cells. Chronic cigarette smoking and oxidative stress are major risk factors for lung fibrosis. This study aims to develop an adverse outcome pathway (AOP) to investigate the mechanisms of lung fibrosis due to lung injury caused by inhaled toxicants, including cigarette smoke. Cellular and tissue-level events lead to the development of lung fibrosis through proinflammatory and profibrotic mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ping Zhan, Xue Lu, Zhao Li, Wen-Jing Wang, Kun Peng, Nan-Nan Liang, Yan Wang, Jian Li, Lin Fu, Hui Zhao, De-Xiang Xu, Zhu-Xia Tan
Summary: This study explored the role of mitochondrial reactive oxygen species (ROS) in bleomycin-induced acute lung injury (ALI) and ferroptosis of pulmonary epithelial cells. Mitochondria-targeted antioxidants may serve as potential therapeutic agents for bleomycin-induced ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Megane Lebel, Dominic O. Cliche, Martine Charbonneau, Damien Adam, Emmanuelle Brochiero, Claire M. Dubois, Andre M. Cantin
Summary: Idiopathic pulmonary fibrosis (IPF) is characterized by abnormal fibroblast accumulation in the lung leading to compromised lung function. This study investigated the mechanisms of interstitial invasion and remodeling by lung fibroblasts in IPF and found increased invadosome formation. Additionally, two drugs approved for treating IPF, nintedanib and pirfenidone, were found to suppress invadosome formation in IPF lung fibroblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tim J. M. Wallis, Magdalena Minnion, Anna Freeman, Andrew Bates, James M. Otto, Stephen A. Wootton, Sophie V. Fletcher, Michael P. W. Grocott, Martin Feelisch, Mark G. Jones, Sandy Jack
Summary: A study found that individualized aerobic interval training can improve exercise capacity and redox status in idiopathic pulmonary fibrosis (IPF) patients. After an 8-week training program, patients showed significant improvements in exercise capacity and redox status.
Review
Biochemistry & Molecular Biology
Suneel Kumar, Thomas Theis, Monica Tschang, Vini Nagaraj, Francois Berthiaume
Summary: Traumatic injuries to the nervous system, such as spinal cord injury and brain injury, can result in neurological dysfunction, causing patients to be bed-ridden and immobile for extended periods. Secondary complications like bladder/bowel dysfunction and pressure ulcers can lead to further debilitating conditions.
Article
Environmental Sciences
Lin Fu, Hui Zhao, Ying Xiang, Hui-Xian Xiang, Biao Hu, Zhu-Xia Tan, Xue Lu, Lan Gao, Bo Wang, Hua Wang, Cheng Zhang, De-Xiang Xu
Summary: Chronic exposure to 1-nitropyrene (1-NP) induces pulmonary fibrosis in mice, potentially through oxidative stress-induced endoplasmic reticulum stress leading to epithelial-mesenchymal transition.
ENVIRONMENTAL POLLUTION
(2021)
Article
Nanoscience & Nanotechnology
Xidong Tian, Hriday Bera, Xiong Guo, Ruizhao Xu, Jin Sun, Zhonggui He, Dongmei Cun, Mingshi Yang
Summary: This study introduced redox-responsive PTX dimeric nanoparticles for pulmonary delivery to achieve effective therapeutic outcomes against metastatic lung cancer with reduced systemic and local toxicities. These nanoparticles exhibited optimal drug release behavior, excellent colloidal stability, cellular uptake efficiency, and discriminating cytotoxicity between cancer and healthy cells. In a mouse model of metastatic lung cancer, intratracheally delivered PTX dimeric nanoparticles showed stronger anticancer potential with reduced systemic toxicity compared to traditional Taxol intravenous injection.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Plant Sciences
Jiajie Jiang, Te-chan Kao, Sihan Hu, Yubing Li, Weiyi Feng, Xiaochuan Guo, Jinhao Zeng, Xiao Ma
Summary: Baicalin at the dose of 10-200 mg/kg exerts protective effects against the progression of lung injury (LI) to idiopathic pulmonary fibrosis (IPF) through anti-inflammatory and anti-apoptotic pathways.
Article
Pharmacology & Pharmacy
Ankush Sharma, Devesh Tewari, Seyed Fazel Nabavi, Seyed Mohammad Nabavi, Solomon Habtemariam
Summary: The lungs, with the largest surface area in the body, are more susceptible to airborne pathogens and pollutants that mediate pathologies through ROS. Excessive ROS production leads to pulmonary diseases, where mitochondrial dysfunction plays a prominent role, and therapeutic strategies include reducing oxidative stress.
CURRENT OPINION IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yang Liu, Shujun Zhou, Du Xiang, Lingao Ju, Dexin Shen, Xinghuan Wang, Yanfeng Wang
Summary: Acute lung injury (ALI) is a condition caused by various factors leading to acute hypoxic respiratory insufficiency, with oxidative stress playing a significant role in its pathogenesis. While antioxidants can alleviate ALI by scavenging ROS, they may have no significant effect and could even aggravate severe organ injury.
Review
Microbiology
Filippo Patrucco, Paolo Solidoro, Francesco Gavelli, Daria Apostolo, Mattia Bellan
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrosing disease where immune cells play a complex role in orchestrating the fibrosing response. Post-COVID pulmonary fibrosis (PCPF) is an emerging clinical entity that shares many similarities with IPF, including pathophysiological processes and response to treatments. SARS-CoV-2 infection can also cause acute exacerbation of IPF and negatively impact prognosis.
Article
Cell Biology
Josep Mercader-Barcelo, Aina Martin-Medina, Joan Truyols-Vives, Gabriel Escarrer-Garau, Linda Elowsson, Ana Montes-Worboys, Carlos Rio-Bocos, Josep Muncunill-Farreny, Julio Velasco-Roca, Anna Cederberg, Mans Kadefors, Maria Molina-Molina, Gunilla Westergren-Thorsson, Ernest Sala-Llinas
Summary: Idiopathic pulmonary fibrosis (IPF) is characterized by abnormal repair response and uncontrolled turnover of extracellular matrix. Lung resident mesenchymal stem cells (LRMSC) are believed to play an important role in IPF, but their contribution is not fully understood. This study analyzed LRMSC isolated from IPF patients and control patients, and found that oxidative phosphorylation was dysregulated in IPF LRMSC. Additionally, mitochondrial dysfunction and impaired autophagy response were observed in IPF LRMSC, which might contribute to the development of IPF.
Article
Critical Care Medicine
Yosafe Wakwaya, Deepa Ramdurai, Jeffrey J. Swigris
Summary: Chronic cough in patients with IPF may involve multiple mechanisms, including comorbid conditions and IPF itself. Diagnostic and management approaches need to be multi-faceted, but may lack robust data support.
Review
Medicine, General & Internal
Sonsoles Piera-Velazquez, Sergio A. Jimenez
Summary: Excessive oxidative stress caused by high levels of ROS has been implicated in the development of fibrosis in SSc, with NOX4 being suggested as a potential therapeutic target. The involvement of NOX4 in the production of fibrotic proteins and ROS, as well as its potential role in endothelial and vascular abnormalities, suggests it as a novel target for treating SSc.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)