NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17β-Estradiol

Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury

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Probenecid protects against oxygen–glucose deprivation injury in primary astrocytes by regulating inflammasome activity

(2016) Zhihong Jian et al.   BRAIN RESEARCH

PELP1: Structure, biological function and clinical significance

(2016) Gangadhara Reddy Sareddy et al.   GENE

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

(2016) Julien Couturier et al.   Journal of Neuroinflammation

Expression level of P2X7 receptor is a determinant of ATP-induced death of mouse cultured neurons

(2016) A. Ohishi et al.   NEUROSCIENCE

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

Estrogen receptor beta signaling alters cellular inflammasomes activity after global cerebral ischemia in reproductively senescence female rats

(2015) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF NEUROCHEMISTRY

The pathogenic role of the inflammasome in neurodegenerative diseases

(2015) Leslie C. Freeman et al.   JOURNAL OF NEUROCHEMISTRY

Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons

(2015) Yu-Chan Wang et al.   Journal of Neuroinflammation

Inflammasomes are neuroprotective targets for sex steroids

(2015) Alexander Slowik et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain

(2015) Leoni Lammerding et al.   NEUROENDOCRINOLOGY

Neuroprotection in Parkinsonian-treated mice via estrogen receptor α activation requires G protein-coupled estrogen receptor 1

(2015) Mélanie Bourque et al.   NEUROPHARMACOLOGY

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

(2015) Xiangxiang Wang et al.   NEUROSCIENCE LETTERS

Proline-, glutamic acid-, and leucine-rich protein 1 mediates estrogen rapid signaling and neuroprotection in the brain

(2015) Gangadhara R. Sareddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3

(2015) Adam Denes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells

(2015) Xiaolan Wang et al.   TOXICOLOGY

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK

(2015) Ying Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Intermittent fasting attenuates inflammasome activity in ischemic stroke

(2014) David Yang-Wei Fann et al.   EXPERIMENTAL NEUROLOGY

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

(2014) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

GPR30 mediates estrogen rapid signaling and neuroprotection

(2014) Hui Tang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Estrogen biology: New insights into GPER function and clinical opportunities

(2014) Eric R. Prossnitz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The neuroprotective actions of oestradiol and oestrogen receptors

(2014) Maria-Angeles Arevalo et al.   NATURE REVIEWS NEUROSCIENCE

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

(2014) Silvia Alfonso-Loeches et al.   Frontiers in Cellular Neuroscience

Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model

(2013) Huan-Dong Liu et al.   NEUROCHEMICAL RESEARCH

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

ATP release and purinergic signaling in NLRP3 inflammasome activation

(2013) Aurélie Gombault et al.   Frontiers in Immunology

P2X7 signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand

(2012) Ying-mei Lu et al.   Journal of Neuroinflammation

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

An Automated Method to Quantify Microglia Morphology and Application to Monitor Activation State Longitudinally In Vivo

(2012) Cleopatra Kozlowski et al.   PLoS One

Gonadal steroids prevent cell damage and stimulate behavioral recovery after transient middle cerebral artery occlusion in male and female rats

(2011) Jon Dang et al.   BRAIN BEHAVIOR AND IMMUNITY

Production of Proinflammatory Cytokines and Chemokines During Neuroinflammation: Novel Roles for Estrogen Receptors α and β

(2010) Candice M. Brown et al.   ENDOCRINOLOGY

Extranuclear Estrogen Receptors Mediate the Neuroprotective Effects of Estrogen in the Rat Hippocampus

(2010) Li-cai Yang et al.   PLoS One

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Estrogen Attenuates Ischemic Oxidative Damage via an Estrogen Receptor  -Mediated Inhibition of NADPH Oxidase Activation

(2009) Q.-G. Zhang et al.   JOURNAL OF NEUROSCIENCE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Estradiol rescues neurons from global ischemia-induced cell death: Multiple cellular pathways of neuroprotection

(2009) Diane Lebesgue et al.   STEROIDS

Review: The potential for estrogens in preventing Alzheimer's disease and vascular dementia

(2009) James W. Simpkins et al.   Therapeutic Advances in Neurological Disorders

Selection of reference genes for quantitative real-time PCR in a rat asphyxial cardiac arrest model

(2008) Kristina Langnaese et al.   BMC MOLECULAR BIOLOGY

Cellular localization of P2X7 receptor mRNA in the rat brain

(2008) Yong Yu et al.   BRAIN RESEARCH

Estrogen anti-inflammatory activity in brain: A therapeutic opportunity for menopause and neurodegenerative diseases

(2008) Elisabetta Vegeto et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands

(2008) Kazuki Nagasawa et al.   GLIA

Role of Dickkopf-1, an Antagonist of the Wnt/ -Catenin Signaling Pathway, in Estrogen-Induced Neuroprotection and Attenuation of Tau Phosphorylation

(2008) Q.-G. Zhang et al.   JOURNAL OF NEUROSCIENCE

PELP1—A novel estrogen receptor-interacting protein

(2008) Darrell W. Brann et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY