Metabolic engineering is key to a sustainable chemical industry

Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis

(2011) Aman A. Desai   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microbial production of building block chemicals and polymers

(2011) Jeong Wook Lee et al.   CURRENT OPINION IN BIOTECHNOLOGY

Fermentative production of butanol—the industrial perspective

(2011) Edward M Green   CURRENT OPINION IN BIOTECHNOLOGY

A literature review on the safety assessment of genetically modified plants

(2011) José L. Domingo et al.   ENVIRONMENT INTERNATIONAL

Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

(2011) Richard K. Henderson et al.   GREEN CHEMISTRY

Converting carbohydrates to bulk chemicals and fine chemicals over heterogeneous catalysts

(2011) Maria J. Climent et al.   GREEN CHEMISTRY

From zero to hero—Design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production

(2011) Judith Becker et al.   METABOLIC ENGINEERING

Chemistry: Enzyme expertise

(2011) Katharine Sanderson   NATURE

Debottlenecking the 1,3-propanediol pathway by metabolic engineering

(2010) E. Celińska   BIOTECHNOLOGY ADVANCES

An Expeditious Route to Fluorinated Rapamycin Analogues by Utilising Mutasynthesis

(2010) Rebecca J. M. Goss et al.   CHEMBIOCHEM

Environmentally Safe Production of 7-ACA by Recombinant Acremonium chrysogenum

(2010) Yan Liu et al.   CURRENT MICROBIOLOGY

Biocatalysis—key to sustainable industrial chemistry

(2010) Roland Wohlgemuth   CURRENT OPINION IN BIOTECHNOLOGY

Metagenomic era for biocatalyst identification

(2010) Lucía Fernández-Arrojo et al.   CURRENT OPINION IN BIOTECHNOLOGY

Recent progress in industrial biocatalysis

(2010) Bettina M Nestl et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Status of protein engineering for biocatalysts: how to design an industrially useful biocatalyst

(2010) Andreas S Bommarius et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Polyhydroxyalkanoates: bioplastics with a green agenda

(2010) Tajalli Keshavarz et al.   CURRENT OPINION IN MICROBIOLOGY

Rhamnolipids: Production in bacteria other than Pseudomonas aeruginosa

(2010) Jeiry Toribio et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

LCA approach to the analysis of solvent waste issues in the pharmaceutical industry

(2010) Michael J. Raymond et al.   GREEN CHEMISTRY

Catalytic conversion of biomass to biofuels

(2010) David Martin Alonso et al.   GREEN CHEMISTRY

Use of modular, synthetic scaffolds for improved production of glucaric acid in engineered E. coli

(2010) Tae Seok Moon et al.   METABOLIC ENGINEERING

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

(2010) Carlos Olano et al.   NATURAL PRODUCT REPORTS

Trends for diverse production strategies of plant medicinal alkaloids

(2010) Liuqing Yang et al.   NATURAL PRODUCT REPORTS

Methods and options for the heterologous production of complex natural products

(2010) Haoran Zhang et al.   NATURAL PRODUCT REPORTS

Regulation must be revolutionized

(2010) Ingo Potrykus   NATURE

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome

(2010) Heinz Neumann et al.   NATURE

Plant natural products from cultured multipotent cells

(2010) Susan Roberts et al.   NATURE BIOTECHNOLOGY

Will the patentability of genes survive?

(2010) Howard Leslie Hoffenberg   NATURE BIOTECHNOLOGY

Cultured cambial meristematic cells as a source of plant natural products

(2010) Eun-Kyong Lee et al.   NATURE BIOTECHNOLOGY

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

(2010) M. Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

A Novel Semi-biosynthetic Route for Artemisinin Production Using Engineered Substrate-Promiscuous P450BM3

(2009) Jeffrey A. Dietrich et al.   ACS Chemical Biology

Biotechnological production and applications of statins

(2009) Javier Barrios-González et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biocatalysis in development of green pharmaceutical processes

(2009) Junhua Tao et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Revisiting the modularity of modular polyketide synthases

(2009) Chaitan Khosla et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Combinatorial biosynthesis of plant medicinal polyketides by microorganisms

(2009) Sueharu Horinouchi   CURRENT OPINION IN CHEMICAL BIOLOGY

Bridging data gaps in environmental assessments: Modeling impacts of fine and basic chemical production

(2009) Gregor Wernet et al.   GREEN CHEMISTRY

Exergetic life cycle analysis for the selection of chromatographic separation processes in the pharmaceutical industry: preparative HPLC versus preparative SFC

(2009) Geert Van der Vorst et al.   GREEN CHEMISTRY

Biocatalytic synthesis of atorvastatin intermediates

(2009) Jay M. Patel   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Directed Evolution of Enantioselective Enzymes: An Unconventional Approach to Asymmetric Catalysis in Organic Chemistry

(2009) Manfred T. Reetz   JOURNAL OF ORGANIC CHEMISTRY

Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: Complete stabilization of plasmids as universal application in white biotechnology

(2009) Jens Kroll et al.   METABOLIC ENGINEERING

Metabolic flux analysis and pharmaceutical production

(2009) Brett A. Boghigian et al.   METABOLIC ENGINEERING

Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds

(2009) John A. McIntosh et al.   NATURAL PRODUCT REPORTS

Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem

(2009) Carmen Cuevas et al.   NATURAL PRODUCT REPORTS

Synthetic protein scaffolds provide modular control over metabolic flux

(2009) John E Dueber et al.   NATURE BIOTECHNOLOGY

Stabilized gene duplication enables long-term selection-free heterologous pathway expression

(2009) Keith E J Tyo et al.   NATURE BIOTECHNOLOGY

Metabolic reprogramming of periwinkle plant culture

(2009) Weerawat Runguphan et al.   Nature Chemical Biology

High-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli

(2009) Hiroko Tsuruta et al.   PLoS One

Rational improvement of simvastatin synthase solubility inEscherichia colileads to higher whole-cell biocatalytic activity

(2008) Xinkai Xie et al.   BIOTECHNOLOGY AND BIOENGINEERING

Exploitation of biological wastes for the production of value‐added products under solid‐state fermentation conditions

(2008) Susana Rodríguez Couto   Biotechnology Journal

Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies

(2008) Jacob R. Lenihan et al.   BIOTECHNOLOGY PROGRESS

Messenger RNA-Programmed Incorporation of Multiple N-Methyl-Amino Acids into Linear and Cyclic Peptides

(2008) Takashi Kawakami et al.   CHEMISTRY & BIOLOGY

Metabolic engineering for plant natural product biosynthesis in microbes

(2008) Joseph A Chemler et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metabolic engineering of natural products in plants; tools of the trade and challenges for the future

(2008) Shuiqin Wu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

(2008) Benedikt Engels et al.   METABOLIC ENGINEERING

Production of curcuminoids by Escherichia coli carrying an artificial biosynthesis pathway

(2008) Y. Katsuyama et al.   MICROBIOLOGY-SGM

Meetings that changed the world: Asilomar 1975: DNA modification secured

(2008) Paul Berg   NATURE

The advent and development of organocatalysis

(2008) David W. C. MacMillan   NATURE

Engineered biosynthesis of hybrid macrolide polyketides containing d-angolosamine and d-mycaminose moieties

(2008) Ursula Schell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Improvement of erythromycin production by Saccharopolyspora erythraea in molasses based medium through cultivation medium optimization

(2007) H.A. El-Enshasy et al.   BIORESOURCE TECHNOLOGY

Recent applications of biocatalysis in developing green chemistry for chemical synthesis at the industrial scale

(2007) Ningqing Ran et al.   GREEN CHEMISTRY

Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation

(2007) Kim Alfonsi et al.   GREEN CHEMISTRY