The multifaceted role of ischemia/reperfusion in sickle cell anemia
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Title
The multifaceted role of ischemia/reperfusion in sickle cell anemia
Authors
Keywords
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Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 130, Issue 3, Pages 1062-1072
Publisher
American Society for Clinical Investigation
Online
2020-03-10
DOI
10.1172/jci133639
References
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Note: Only part of the references are listed.- Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion
- (2019) Anson MacKinney et al. Redox Biology
- Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium
- (2019) Huy Tran et al. Frontiers in Cellular Neuroscience
- Murine Model of Pulmonary Artery Overflow Vasculopathy Revealed Macrophage Accumulation in the Lung
- (2019) Shun Minatsuki et al. International Heart Journal
- Sickle Cell Microvascular Paradox – oxygen supply‐demand mismatch
- (2019) Jon A. Detterich et al. AMERICAN JOURNAL OF HEMATOLOGY
- White matter has impaired resting oxygen delivery in sickle cell patients
- (2019) Yaqiong Chai et al. AMERICAN JOURNAL OF HEMATOLOGY
- Brain O2 reserve in sickle cell disease
- (2019) John C. Wood BLOOD
- Attenuating Pulmonary Hypertension by Protecting the Integrity of Glycocalyx in Rats Model of Pulmonary Artery Hypertension
- (2019) Jing Guo et al. INFLAMMATION
- A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease
- (2019) Elliott Vichinsky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Moderate exercise training decreases inflammation in transgenic sickle cell mice
- (2018) Emmanuelle Charrin et al. BLOOD CELLS MOLECULES AND DISEASES
- Renal protection by atorvastatin in a murine model of sickle cell nephropathy
- (2018) Rima S. Zahr et al. BRITISH JOURNAL OF HAEMATOLOGY
- Hypercoagulable state in sickle cell disease
- (2018) Camille Faes et al. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
- Induction of NLRP3 Inflammasome Activation by Heme in Human Endothelial Cells
- (2018) Judit Erdei et al. Oxidative Medicine and Cellular Longevity
- Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats
- (2018) Rikesh M. Rajani et al. Science Translational Medicine
- The Missing Middle of Sickle Therapeutics: Multi-agent Therapy, Targeting Risk, Using Biomarkers
- (2018) Robert P. Hebbel et al. AMERICAN JOURNAL OF HEMATOLOGY
- Silent infarcts in sickle cell anemia occur in the borderzone region and are associated with low cerebral blood flow
- (2018) Andria L. Ford et al. BLOOD
- Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction
- (2018) John D. Belcher et al. PLoS One
- Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia
- (2018) John D. Belcher et al. PLoS One
- Critical role of C5a in sickle cell disease
- (2018) Gregory M. Vercellotti et al. AMERICAN JOURNAL OF HEMATOLOGY
- Resolution of sickle cell disease–associated inflammation and tissue damage with 17R-resolvin D1
- (2018) Alessandro Matte et al. BLOOD
- Therapeutic strategies for sickle cell disease: towards a multi-agent approach
- (2018) Marilyn J. Telen et al. NATURE REVIEWS DRUG DISCOVERY
- Cerebral hemodynamic assessment and neuroimaging across the lifespan in sickle cell disease
- (2017) Lori C Jordan et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Higher prevalence of spontaneous cerebral vasculopathy and cerebral infarcts in a mouse model of sickle cell disease
- (2017) Hyacinth I Hyacinth et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Intravascular hemolysis and the pathophysiology of sickle cell disease
- (2017) Gregory J. Kato et al. JOURNAL OF CLINICAL INVESTIGATION
- Does pathology of small venules contribute to cerebral microinfarcts and dementia?
- (2017) David A. Hartmann et al. JOURNAL OF NEUROCHEMISTRY
- Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease
- (2017) Kenneth I. Ataga et al. NEW ENGLAND JOURNAL OF MEDICINE
- Brain neurochemical and hemodynamic findings in the NY1DD mouse model of mild sickle cell disease
- (2017) Min-Hui Cui et al. NMR IN BIOMEDICINE
- Sickle Mice Are Sensitive to Hypoxia/Ischemia-Induced Stroke but Respond to Tissue-Type Plasminogen Activator Treatment
- (2017) Yu-Yo Sun et al. STROKE
- Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology
- (2016) D. Zhang et al. BLOOD
- Sevuparin binds to multiple adhesive ligands and reduces sickle red blood cell-induced vaso-occlusion
- (2016) Marilyn J. Telen et al. BRITISH JOURNAL OF HAEMATOLOGY
- Microparticles in sickle cell anaemia: promise and pitfalls
- (2016) Robert P. Hebbel et al. BRITISH JOURNAL OF HAEMATOLOGY
- Sickle red cells as danger signals on proinflammatory gene expression, leukotriene B4 and interleukin-1 beta production in peripheral blood mononuclear cell
- (2016) Thassila N. Pitanga et al. CYTOKINE
- Functional and anatomical evidence of cerebral tissue hypoxia in young sickle cell anemia mice
- (2016) Lindsay S Cahill et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Middle cerebral artery remodeling following transient brain ischemia is linked to early postischemic hyperemia: A target of uric acid treatment
- (2015) Yara Onetti et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease
- (2015) S. M. Camus et al. BLOOD
- Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases
- (2015) Bernhard F. Becker et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Sickle cell disease: renal manifestations and mechanisms
- (2015) Karl A. Nath et al. Nature Reviews Nephrology
- The blood–brain barrier—Gatekeeper to neuronal homeostasis: Clinical implications in the setting of stroke
- (2015) Karl Schoknecht et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Reperfusion injury and reactive oxygen species: The evolution of a concept
- (2015) D. Neil Granger et al. Redox Biology
- The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice
- (2015) John D. Belcher et al. PLoS One
- Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation
- (2014) H. Xu et al. BLOOD
- Ischemia-reperfusion Injury in Sickle Cell Anemia
- (2014) Robert P. Hebbel HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
- Inflammatory Mediators of Endothelial Injury in Sickle Cell Disease
- (2014) Carolyn C. Hoppe HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
- Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns
- (2014) Liliana Schaefer JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct measurement of local oxygen concentration in the bone marrow of live animals
- (2014) Joel A. Spencer et al. NATURE
- Obstructive Sleep Apnea and Sickle Cell Anemia
- (2014) C. L. Rosen et al. PEDIATRICS
- Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4
- (2014) Katharine J. Goodall et al. PLoS One
- Hemolysis-induced lethality involves inflammasome activation by heme
- (2014) Fabianno F. Dutra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Donor Simvastatin Treatment Prevents Ischemia-Reperfusion and Acute Kidney Injury by Preserving Microvascular Barrier Function
- (2013) R. Tuuminen et al. AMERICAN JOURNAL OF TRANSPLANTATION
- MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice
- (2013) J. D. Belcher et al. BLOOD
- Mast cell activation contributes to sickle cell pathobiology and pain in mice
- (2013) L. Vincent et al. BLOOD
- Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
- (2013) J. D. Belcher et al. BLOOD
- The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo
- (2013) Peter F. Davies et al. CARDIOVASCULAR RESEARCH
- Thrombospondin-1 inhibits ADAMTS13 activity in sickle cell disease
- (2013) E. M. Novelli et al. HAEMATOLOGICA
- Unknown
- (2013) Eileen Bauer et al. MOLECULAR MEDICINE
- A potent oral P-selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease
- (2012) Abdullah Kutlar et al. AMERICAN JOURNAL OF HEMATOLOGY
- Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease
- (2012) S. M. Camus et al. BLOOD
- Molecular pathogenesis of pulmonary arterial hypertension
- (2012) Marlene Rabinovitch JOURNAL OF CLINICAL INVESTIGATION
- The Association Between a Darc Gene Polymorphism and Clinical Outcomes in African American Patients With Acute Lung Injury
- (2011) Kirsten Neudoerffer Kangelaris et al. CHEST
- Ischemia and reperfusion—from mechanism to translation
- (2011) Holger K Eltzschig et al. NATURE MEDICINE
- Mechanisms of disease: pulmonary arterial hypertension
- (2011) Ralph T. Schermuly et al. Nature Reviews Cardiology
- Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
- (2011) Grant R. Drummond et al. NATURE REVIEWS DRUG DISCOVERY
- Reconstructing sickle cell disease: A data-based analysis of the “hyperhemolysis paradigm” for pulmonary hypertension from the perspective of evidence-based medicine
- (2010) Robert P. Hebbel AMERICAN JOURNAL OF HEMATOLOGY
- The role of monocytes in atherosclerotic coronary artery disease
- (2010) Burak Pamukcu et al. ANNALS OF MEDICINE
- P-Selectin–Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease
- (2010) Renata Polanowska-Grabowska et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Direct relationship between levels of TNF-α expression and endothelial dysfunction in reperfusion injury
- (2010) Cuihua Zhang et al. BASIC RESEARCH IN CARDIOLOGY
- The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice
- (2010) R. P. Hebbel et al. BLOOD
- Statins and Ischaemia Reperfusion Injury: A Molecular Biological Review
- (2010) M. N.A. Abdul Rahman et al. Current Vascular Pharmacology
- Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy
- (2010) A. Siciliano et al. HAEMATOLOGICA
- Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease
- (2010) John D. Belcher et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Lacunar stroke is associated with diffuse blood-brain barrier dysfunction
- (2009) Joanna M. Wardlaw et al. ANNALS OF NEUROLOGY
- Human Sickle Cell Blood Modulates Endothelial Heme Oxygenase Activity
- (2009) Sandip K. Bains et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death
- (2009) Gregory J. Kato et al. BRITISH JOURNAL OF HAEMATOLOGY
- Molecular mechanisms of endothelial hyperpermeability: implications in inflammation
- (2009) Puneet Kumar et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Hemodynamic Etiology of Elevated Flow Velocity and Stroke in Sickle-Cell Disease
- (2009) Isak Prohovnik et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury
- (2009) Andrés Hidalgo et al. NATURE MEDICINE
- Nuclear factor-kappa B (NFκB) component p50 in blood mononuclear cells regulates endothelial tissue factor expression in sickle transgenic mice: implications for the coagulopathy of sickle cell disease
- (2009) Rahn Kollander et al. Translational Research
- Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status
- (2008) Mark J. Crabtree et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Unknown
- (2008) Bart Ferwerda et al. MOLECULAR MEDICINE
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