Sevuparin binds to multiple adhesive ligands and reduces sickle red blood cell-induced vaso-occlusion

MEK1/2 inhibitors reverse acute vascular occlusion in mouse models of sickle cell disease

(2016) Yulin Zhao et al.   FASEB JOURNAL

Single-dose intravenous gammaglobulin can stabilize neutrophil Mac-1 activation in sickle cell pain crisis

(2015) Deepa Manwani et al.   AMERICAN JOURNAL OF HEMATOLOGY

Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use

(2015) M. J. Telen et al.   BLOOD

Hydroxycarbamide Decreases Sickle Reticulocyte Adhesion to Resting Endothelium by Inhibiting Endothelial Lutheran/Basal Cell Adhesion Molecule (Lu/BCAM) through Phosphodiesterase 4A Activation

(2014) Vicky Chaar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MEK Inhibitors, Novel Anti-Adhesive Molecules, Reduce Sickle Red Blood Cell Adhesion In Vitro and In Vivo, and Vasoocclusion In Vivo

(2014) Rahima Zennadi   PLoS One

Neuropathy, neuropathic pain, and sickle cell disease

(2013) Samir K. Ballas et al.   AMERICAN JOURNAL OF HEMATOLOGY

Sickle Cell Disease

(2013) Martin H. Steinberg   ANNALS OF INTERNAL MEDICINE

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

(2013) D. Manwani et al.   BLOOD

Thrombospondin-1 and L-selectin are associated with silent cerebral infarct in children with sickle cell anaemia

(2013) Lisa M. Faulcon et al.   BRITISH JOURNAL OF HAEMATOLOGY

Interplay between coagulation and vascular inflammation in sickle cell disease

(2013) Erica Sparkenbaugh et al.   BRITISH JOURNAL OF HAEMATOLOGY

A potent oral P-selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease

(2012) Abdullah Kutlar et al.   AMERICAN JOURNAL OF HEMATOLOGY

Effect of Propranolol as Antiadhesive Therapy in Sickle Cell Disease

(2012) Laura M. De Castro et al.   CTS-Clinical and Translational Science

Association of Coagulation Activation with Clinical Complications in Sickle Cell Disease

(2012) Kenneth I. Ataga et al.   PLoS One

Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates

(2011) Enrico M Novelli et al.   AMERICAN JOURNAL OF HEMATOLOGY

Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium

(2011) R. Zennadi et al.   BLOOD

The rate of hemolysis in sickle cell disease correlates with the quantity of active von Willebrand factor in the plasma

(2011) J. Chen et al.   BLOOD

RNA Aptamer Therapy for Vaso-Occlusion in Sickle Cell Disease

(2011) Angela D. Burnette et al.   Nucleic Acid Therapeutics

Severe sickle cell anemia is associated with increased plasma levels of TNF-R1 and VCAM-1

(2010) Daniel A. Dworkis et al.   AMERICAN JOURNAL OF HEMATOLOGY

P-Selectin–Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease

(2010) Renata Polanowska-Grabowska et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease

(2010) D. R. Gutsaeva et al.   BLOOD

Decreased sickle red blood cell adhesion to laminin by hydroxyurea is associated with inhibition of Lu/BCAM protein phosphorylation

(2010) P. Bartolucci et al.   BLOOD

The inherited diseases of hemoglobin are an emerging global health burden

(2010) D. J. Weatherall   BLOOD

GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice

(2010) J. Chang et al.   BLOOD

Intercellular adhesion molecule-4 and CD36 are implicated in the abnormal adhesiveness of sickle cell SAD mouse erythrocytes to endothelium

(2009) M. M. Trinh-Trang-Tan et al.   HAEMATOLOGICA

Leukocyte - endothelial interactions in inflammation

(2009) Harald F. Langer et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury

(2009) Andrés Hidalgo et al.   NATURE MEDICINE

Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium

(2008) R. Zennadi et al.   BLOOD

Modulation of erythroid adhesion receptor expression by hydroxyurea in children with sickle cell disease

(2008) M.-H. Odievre et al.   HAEMATOLOGICA

Increased von Willebrand factor antigen and high molecular weight multimers in sickle cell disease associated with nocturnal hypoxemia

(2008) Suba Krishnan et al.   THROMBOSIS RESEARCH

Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain

(2008) Suhita Gayen Betal et al.   Translational Research

Intravenous immunoglobulins reverse acute vaso-occlusive crises in sickle cell mice through rapid inhibition of neutrophil adhesion

(2007) J. Chang et al.   BLOOD

What a polyclonal antibody sees in von Willebrand factor

(2007) Fen-Lai Tan et al.   THROMBOSIS RESEARCH