Telomere Length Maintenance in Cancer: At the Crossroad between Telomerase and Alternative Lengthening of Telomeres (ALT)

Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells

(2018) Dongliang Mo et al.   CANCER LETTERS

Systematic analysis of telomere length and somatic alterations in 31 cancer types

(2017) Floris P Barthel et al.   NATURE GENETICS

Alternative Lengthening of Telomeres: DNA Repair Pathways Converge

(2017) Alexander P. Sobinoff et al.   TRENDS IN GENETICS

Highly Aggressive Metastatic Melanoma Cells Unable to Maintain Telomere Length

(2017) Nikenza Viceconte et al.   Cell Reports

Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres

(2017) Rebecca A. Dagg et al.   Cell Reports

Reactivation of telomerase in cancer

(2016) Semih Can Akincilar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Implications of telomeres and telomerase in endometrial pathology

(2016) D.K. Hapangama et al.   HUMAN REPRODUCTION UPDATE

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition

(2016) Valentine Comaills et al.   Cell Reports

The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) Phenotype

(2016) João Amorim et al.   Genes

Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX

(2016) Yang Hu et al.   Scientific Reports

Leiomyosarcoma With Alternative Lengthening of Telomeres Is Associated With Aggressive Histologic Features, Loss of ATRX Expression, and Poor Clinical Outcome

(2015) Jau-Yu Liau et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Alternative lengthening of telomeres phenotype in malignant vascular tumors is highly associated with loss of ATRX expression and is frequently observed in hepatic angiosarcomas

(2015) Jau-Yu Liau et al.   HUMAN PATHOLOGY

Comprehensive screening of alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas

(2015) Jau-Yu Liau et al.   MODERN PATHOLOGY

Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas

(2015) Jen-Chieh Lee et al.   MODERN PATHOLOGY

ATRX represses alternative lengthening of telomeres

(2015) Christine E. Napier et al.   Oncotarget

Intratumoral diversity of telomere length in individual neuroblastoma tumors

(2015) Annalisa Pezzolo et al.   Oncotarget

Telomerase-Dependent and Independent Telomere Maintenance and its Clinical Implications in Medullary Thyroid Carcinoma

(2014) Na Wang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

(2014) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin

(2014) Harikleia Episkopou et al.   NUCLEIC ACIDS RESEARCH

Alternative lengthening of telomeres in cancer stem cells in vivo

(2014) B Bojovic et al.   ONCOGENE

Assembly of telomeric chromatin to create ALTernative endings

(2014) Roderick J. O'Sullivan et al.   TRENDS IN CELL BIOLOGY

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

(2014) Xiang Chen et al.   Cell Reports

Oxidative stress in melanocyte senescence and melanoma transformation

(2013) Svenja Meierjohann   EUROPEAN JOURNAL OF CELL BIOLOGY

Telomere recombination and alternative telomere lengthening mechanisms

(2013) Arturo Vallejo   Frontiers in Bioscience-Landmark

Loss of DAXX and ATRX Are Associated With Chromosome Instability and Reduced Survival of Patients With Pancreatic Neuroendocrine Tumors

(2013) Ilaria Marinoni et al.   GASTROENTEROLOGY

The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas

(2013) Malak Abedalthagafi et al.   MODERN PATHOLOGY

Correlation of Chromosomal Instability, Telomere Length and Telomere Maintenance in Microsatellite Stable Rectal Cancer: A Molecular Subclass of Rectal Cancer

(2013) Lisa A. Boardman et al.   PLoS One

The co-expression of telomerase and ALT pathway in human breast cancer tissues

(2013) Bin Xu et al.   TUMOR BIOLOGY

Human Sarcomas Are Mosaic for Telomerase-Dependent and Telomerase-Independent Telomere Maintenance Mechanisms

(2012) April R.S. Gocha et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular and Morphologic Correlates of the Alternative Lengthening of Telomeres Phenotype in High-Grade Astrocytomas

(2012) Doreen N. Nguyen et al.   BRAIN PATHOLOGY

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

(2012) Jian Hu et al.   CELL

Association of Age at Diagnosis and Genetic Mutations in Patients With Neuroblastoma

(2012) Nai-Kong V. Cheung   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance

(2012) L. Venturini et al.   NEURO-ONCOLOGY

Loss of Wild-Type ATRX Expression in Somatic Cell Hybrids Segregates with Activation of Alternative Lengthening of Telomeres

(2012) Kylie Bower et al.   PLoS One

Cancer and Telomeres--An ALTernative to Telomerase

(2012) J. W. Shay et al.   SCIENCE

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

Modulation of Telomeres in Alternative Lengthening of Telomeres Type I Like Human Cells by the Expression of Werner Protein and Telomerase

(2012) Aisha Siddiqa et al.   Journal of Oncology

Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

(2011) Christopher M. Heaphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Recombination Can either Help Maintain Very Short Telomeres or Generate Longer Telomeres in Yeast Cells with Weak Telomerase Activity

(2011) Evelina Basenko et al.   EUKARYOTIC CELL

Telomere maintenance in wilms tumors: First evidence for the presence of alternative lengthening of telomeres mechanism

(2011) Lorenza Venturini et al.   GENES CHROMOSOMES & CANCER

Twisted Epithelial-to-Mesenchymal Transition Promotes Progression of Surviving Bladder Cancer T24 Cells with hTERT-Dysfunction

(2011) Yan Xue et al.   PLoS One

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis

(2010) Lorenza Venturini et al.   BMC CANCER

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers

(2010) Jeremy D. Henson et al.   FEBS LETTERS

Telomerase inhibition alters telomere maintenance mechanisms in laryngeal squamous carcinoma cells

(2010) W Chen et al.   JOURNAL OF LARYNGOLOGY AND OTOLOGY

Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival

(2010) Kerrie L. McDonald et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Telomeric recombination induced by dysfunctional telomeres

(2010) Marie Eve Brault et al.   MOLECULAR BIOLOGY OF THE CELL

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of telomere length by a trimming mechanism that involves generation of t-circles

(2009) Hilda A Pickett et al.   EMBO JOURNAL

Telomere-Maintenance Mechanisms in Soft-Tissue Malignant Fibrous Histiocytomas

(2009) Toshihiro Matsuo et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression

(2009) Andrea Proctor Subhawong et al.   MODERN PATHOLOGY

Short Telomeres Initiate Telomere Recombination in Primary and Tumor Cells

(2009) Tammy A. Morrish et al.   PLoS Genetics

Alternative lengthening of telomeres frequently occurs in mismatch repair system-deficient gastric carcinoma

(2008) Yasuhiro Omori et al.   CANCER SCIENCE

EMT and MET in carcinoma—clinical observations, regulatory pathways and new models

(2008) Erik W. Thompson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Multiple Mechanisms of Telomere Maintenance Exist and Differentially Affect Clinical Outcome in Diffuse Malignant Peritoneal Mesothelioma

(2008) R. Villa et al.   CLINICAL CANCER RESEARCH

Zeb1 links epithelial-mesenchymal transition and cellular senescence

(2008) Y. Liu et al.   DEVELOPMENT

Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies

(2008) Jennie N. Jeyapalan et al.   INTERNATIONAL JOURNAL OF CANCER

Evaluation of Telomere Length Maintenance Mechanisms in Adrenocortical Carcinoma

(2008) Tobias Else et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Unusual Telomeric DNAs in Human Telomerase-Negative Immortalized Cells

(2008) A. Nabetani et al.   MOLECULAR AND CELLULAR BIOLOGY

Unusually stable abnormal karyotype in a highly aggressive melanoma negative for telomerase activity

(2008) Sarantis Gagos et al.   Molecular Cytogenetics