The Interplay between Diabetes and Alzheimer’s Disease—In the Hunt for Biomarkers

Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease–Related β-Amyloid Status

(2019) Sebastian Palmqvist et al.   JAMA Neurology

Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys

(2019) Kylie Kavanagh et al.   Frontiers in Neuroscience

Association of S100B Serum Levels with Metabolic Syndrome and its Components

(2018) Sorayya Kheirouri et al.   Acta Medica Portuguesa

Evidence for brain glucose dysregulation in Alzheimer's disease

(2018) Yang An et al.   Alzheimers & Dementia

High performance plasma amyloid-β biomarkers for Alzheimer’s disease

(2018) Akinori Nakamura et al.   NATURE

Plasma MCP-1 and Cognitive Decline in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: A Two-year Follow-up Study

(2018) Wei-Ju Lee et al.   Scientific Reports

Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits

(2018) Shreyasi Chatterjee et al.   Frontiers in Neuroscience

Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy

(2018) Taeko Kimura et al.   Frontiers in Neuroscience

Exploration of the Anti-Inflammatory Drug Space Through Network Pharmacology: Applications for Drug Repurposing

(2018) Guillermo de Anda-Jáuregui et al.   Frontiers in Physiology

BACE1 as a Potential Biomarker for Alzheimer's Disease

(2018) Boris Decourt et al.   JOURNAL OF ALZHEIMERS DISEASE

Aβ1-17 is a Major Amyloid-β Fragment Isoform in Cerebrospinal Fluid and Blood with Possible Diagnostic Value in Alzheimer's Disease

(2018) Virginia Pérez-Grijalba et al.   JOURNAL OF ALZHEIMERS DISEASE

S100 proteins in rheumatic diseases

(2018) Judith Austermann et al.   Nature Reviews Rheumatology

S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimer’s Disease

(2018) Chao Wang et al.   Scientific Reports

Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer’s disease

(2018) Piotr Lewczuk et al.   Alzheimers Research & Therapy

Current state of Alzheimer’s fluid biomarkers

(2018) José Luis Molinuevo et al.   ACTA NEUROPATHOLOGICA

Type 2 Diabetes Mellitus and Alzheimer’s Disease: Role of Insulin Signalling and Therapeutic Implications

(2018) Andrea Tumminia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability

(2018) Alejandra D. Alonso et al.   Frontiers in Cellular Neuroscience

Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer’s disease

(2018) Sima Kianpour Rad et al.   Drug Design Development and Therapy

The Early Events That Initiate β-Amyloid Aggregation in Alzheimer’s Disease

(2018) Xingyu Zhang et al.   Frontiers in Aging Neuroscience

High-glucose induces tau hyperphosphorylation through activation of TLR9-P38MAPK pathway

(2017) Yue Sun et al.   EXPERIMENTAL CELL RESEARCH

Diabetes is Not Associated with Alzheimer’s Disease Neuropathology

(2017) Maria Niures Pimentel dos Santos Matioli et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin resistance in Alzheimer's disease

(2017) Thomas Diehl et al.   Translational Research

Pre-Clinical Detection of Alzheimer's Disease Using FDG-PET, with or without Amyloid Imaging

(2017) Lisa Mosconi et al.   JOURNAL OF ALZHEIMERS DISEASE

Genetic and functional characterization of disease associations explains comorbidity

(2017) Carlota Rubio-Perez et al.   Scientific Reports

Alzheimer's disease: Targeting the Cholinergic System

(2016) Talita H. Ferreira-Vieira et al.   Current Neuropharmacology

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Plasma tau in Alzheimer disease

(2016) Niklas Mattsson et al.   NEUROLOGY

Effects of glucose and insulin on secretion of amyloid-β by human adipose tissue cells

(2016) William G. Tharp et al.   Obesity

S100A8/A9: From basic science to clinical application

(2016) Monika Pruenster et al.   PHARMACOLOGY & THERAPEUTICS

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

(2016) Mohd Waseem Akhtar et al.   Nature Communications

Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model

(2016) Chuang Guo et al.   Scientific Reports

Diabetes mellitus tipo 2 y enfermedad de Alzheimer: una relación para no olvidar

(2016) Andreea Ciudin   Endocrinologia y Nutricion

Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study

(2016) Magnus Gisslén et al.   EBioMedicine

Plasma β-amyloid in Alzheimer’s disease and vascular disease

(2016) Shorena Janelidze et al.   Scientific Reports

A Key Role of Insulin Receptors in Memory: Figure 1

(2015) Fernanda G. De Felice et al.   DIABETES

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

(2015) Shannon L. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

(2015) Giuseppe Verdile et al.   MEDIATORS OF INFLAMMATION

Biomarkers of Alzheimer Disease, Insulin Resistance, and Obesity in Childhood

(2015) R. Luciano et al.   PEDIATRICS

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion

(2015) Monika Pruenster et al.   Nature Communications

The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease

(2015) Naoyuki Sato et al.   Frontiers in Aging Neuroscience

Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease

(2014) Mirjana Babić et al.   CROATIAN MEDICAL JOURNAL

Insulin Reverses the High-Fat Diet-Induced Increase in Brain A  and Improves Memory in an Animal Model of Alzheimer Disease

(2014) M. Vandal et al.   DIABETES

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Insulin Regulates Brain Function, but How Does It Get There?

(2014) S. M. Gray et al.   DIABETES

Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease

(2014) M. Yarchoan et al.   DIABETES

The Emerging Link betweenO-GlcNAc and Alzheimer Disease

(2014) Yanping Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New drug treatments show neuroprotective effects in Alzheimer′s and Parkinson′s diseases

(2014) Christian Hölscher   Neural Regeneration Research

Amyloid precursor proteins are constituents of the presynaptic active zone

(2013) Melanie Laßek et al.   JOURNAL OF NEUROCHEMISTRY

Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration

(2013) Rahul S Desikan et al.   Molecular Neurodegeneration

Higher glucose levels associated with lower memory and reduced hippocampal microstructure

(2013) L. Kerti et al.   NEUROLOGY

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

High Glucose Promotes Aβ Production by Inhibiting APP Degradation

(2013) Yi Yang et al.   PLoS One

TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons

(2013) Y. Shintani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Glycation exacerbates the neuronal toxicity of β-amyloid

(2013) X-H Li et al.   Cell Death & Disease

The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults

(2013) Virginie Lam et al.   Frontiers in Aging Neuroscience

Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions

(2013) Geert Jan Biessels et al.   Lancet Diabetes & Endocrinology

Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

(2012) Sung Min Son et al.   Autophagy

Astrocytes and disease: a neurodevelopmental perspective

(2012) A. V. Molofsky et al.   GENES & DEVELOPMENT

The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity

(2012) Adam C. Silver et al.   IMMUNITY

The Role of Glucose Transporters in Brain Disease: Diabetes and Alzheimer's Disease

(2012) Kaushik Shah et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

(2012) Latha Devi et al.   PLoS One

Microglia Function in Alzheimer’s Disease

(2012) Egle Solito et al.   Frontiers in Pharmacology

Relating Form and Function of EF-Hand Calcium Binding Proteins

(2011) Walter J. Chazin   ACCOUNTS OF CHEMICAL RESEARCH

Rapidly Progressive Alzheimer Disease

(2011) Christian Schmidt   ARCHIVES OF NEUROLOGY

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

S100B protein in neurodegenerative disorders

(2011) Johann Steiner et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

A Blood-Based Algorithm for the Detection of Alzheimer’s Disease

(2011) Sid E. O’Bryant et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimerʼs Disease

(2011) Suzanne M. de la Monte   DRUGS

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

(2011) Mikko Hiltunen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The S100B protein in biological fluids: more than a lifelong biomarker of brain distress

(2011) Fabrizio Michetti et al.   JOURNAL OF NEUROCHEMISTRY

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation

(2011) Caroline Smet-Nocca et al.   Molecular BioSystems

Non-psychiatric comorbidity associated with Alzheimer's disease

(2011) A. Duthie et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

A Prospective Analysis of Elevated Fasting Glucose Levels and Cognitive Function in Older People: Results From PROSPER and the Rotterdam Study

(2010) S. M. Euser et al.   DIABETES

Serum levels of S100B and NSE proteins in Alzheimer's disease patients

(2010) Márcia L Chaves et al.   Journal of Neuroinflammation

How does diabetes accelerate Alzheimer disease pathology?

(2010) Catrina Sims-Robinson et al.   Nature Reviews Neurology

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease

(2009) Takashi Mori et al.   GLIA

S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase

(2009) Flora Brozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain glucose transporters,O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

(2009) Ying Liu et al.   JOURNAL OF NEUROCHEMISTRY

In Vivo Imaging of Neurotransmission and Brain Receptors in Dementia

(2009) Sabina Pappatà et al.   JOURNAL OF NEUROIMAGING

Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

(2009) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

Effects of insulinic therapy on cognitive impairment in patients with Alzheimer disease and Diabetes Mellitus type-2

(2009) Massimiliano Plastino et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides

(2009) Per Björk et al.   PLOS BIOLOGY

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

(2008) Wei-Qin Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis

(2008) Olga Turovskaya et al.   CARCINOGENESIS

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein

(2008) Pingyan Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Survival in Alzheimer disease: A multiethnic, population-based study of incident cases

(2008) E. P. Helzner et al.   NEUROLOGY

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

(2008) M. Matos et al.   NEUROSCIENCE