The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies

Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy

(2019) Nabil Eid et al.   Cells

Effects of Titanium Dioxide Nanoparticles Exposure on Human Health—a Review

(2019) Ewa Baranowska-Wójcik et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Caenorhabditis elegans as a complete model organism for biosafety assessments of nanoparticles

(2019) Tianshu Wu et al.   CHEMOSPHERE

The zebrafish embryotoxicity test (ZET) for nanotoxicity assessment: from morphological to molecular approach

(2019) Aryelle Canedo Pereira et al.   ENVIRONMENTAL POLLUTION

Lysosomal dysfunction is associated with persistent lung injury in dams caused by pregnancy exposure to carbon black nanoparticles

(2019) Xuemei Liu et al.   LIFE SCIENCES

Molecular mechanisms underlying titanium dioxide nanoparticles (TiO2NP) induced autophagy in mesenchymal stem cells (MSC)

(2019) Shunbang Yu et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Toxicity testing in the 21st century: progress in the past decade and future perspectives

(2019) D. Krewski et al.   ARCHIVES OF TOXICOLOGY

Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease

(2019) Eric M. Clark et al.   Disease Models & Mechanisms

Autophagy in health and disease: A comprehensive review

(2018) Sarbari Saha et al.   BIOMEDICINE & PHARMACOTHERAPY

The proton sponge hypothesis: Fable or fact?

(2018) Lotte M.P. Vermeulen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Zinc oxide nanoparticles induce toxicity in CAL 27 oral cancer cell lines by activating PINK1/Parkin-mediated mitophagy

(2018) Jianfeng Wang et al.   International Journal of Nanomedicine

Silver nanoparticles: Electron transfer, reactive oxygen species, oxidative stress, beneficial and toxicological effects. Mini review

(2018) Lucía Z. Flores-López et al.   JOURNAL OF APPLIED TOXICOLOGY

Assessment of the in vitro genotoxicity of TiO2 nanoparticles in a regulatory context

(2018) Sandrine Charles et al.   Nanotoxicology

Inflammation–coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos

(2018) Junchao Duan et al.   Nanotoxicology

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Rise of Zebrafish as a Model for Toxicology

(2018) Robert L Tanguay   TOXICOLOGICAL SCIENCES

Investigating cell type specific mechanisms contributing to acute oral toxicity

(2018) Pilar Prieto   ALTEX-Alternatives to Animal Experimentation

Silver nanoparticles have lethal and sublethal adverse effects on development and longevity by inducing ROS-mediated stress responses

(2018) Bin-Hsu Mao et al.   Scientific Reports

Quantum Dots Elicit Hepatotoxicity through Lysosome-Dependent Autophagy Activation and Reactive Oxygen Species Production

(2018) Jiajun Fan et al.   ACS Biomaterials-Science & Engineering

Quantum Dots Elicit Hepatotoxicity through Lysosome-Dependent Autophagy Activation and Reactive Oxygen Species Production

(2018) Jiajun Fan et al.   ACS Biomaterials Science & Engineering

Nanoparticles in the environment: where do we come from, where do we go to?

(2018) Mirco Bundschuh et al.   Environmental Sciences Europe

Actin cages isolate damaged mitochondria during mitophagy

(2018) Antonina J. Kruppa et al.   Autophagy

Necrotic, apoptotic and autophagic cell fates triggered by nanoparticles

(2018) Reza Mohammadinejad et al.   Autophagy

Titanium dioxide nanoparticles induce proteostasis disruption and autophagy in human trophoblast cells

(2018) Yuqing Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Health hazards of nanoparticles: understanding the toxicity mechanism of nanosized ZnO in cosmetic products

(2018) Vimala Devi Subramaniam et al.   DRUG AND CHEMICAL TOXICOLOGY

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

Zebrafish as a Model to Evaluate Nanoparticle Toxicity

(2018) Enamul Haque et al.   Nanomaterials

Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity

(2018) Marziyeh Ajdary et al.   Nanomaterials

Autophagy-dependent cell death

(2018) Donna Denton et al.   CELL DEATH AND DIFFERENTIATION

The current application of nanotechnology in food and agriculture

(2018) Xiaojia He et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Copper Oxide Nanoparticles Cause a Dose-Dependent Toxicity via Inducing Reactive Oxygen Species in Drosophila

(2018) Eugene Baeg et al.   Nanomaterials

Lysosomal storage disorders affecting the heart: a review

(2018) Vidhya Nair et al.   CARDIOVASCULAR PATHOLOGY

Combination of graphene oxide–silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells

(2017) Yu-Guo Yuan et al.   International Journal of Nanomedicine

Zinc oxide nanoparticles induce apoptosis and autophagy in human ovarian cancer cells

(2017) Ding-Ping Bai et al.   International Journal of Nanomedicine

Silica nanoparticles induce autophagy dysfunction via lysosomal impairment and inhibition of autophagosome degradation in hepatocytes

(2017) Ji Wang et al.   International Journal of Nanomedicine

Assessment of in vitro antifungal efficacy and in vivo toxicity of Amphotericin B-loaded PLGA and PLGA-PEG blend nanoparticles

(2017) T.C. Moraes Moreira Carraro et al.   JOURNAL DE MYCOLOGIE MEDICALE

Endoplasmic Reticulum Stress-Triggered Autophagy and Lysosomal Dysfunction Contribute to the Cytotoxicity of Amine-Modified Silver Nanoparticles in NIH 3T3 Cells

(2017) Yu-Hsuan Lee et al.   Journal of Biomedical Nanotechnology

The effects of titanium dioxide nanoparticles on ultrastructure of zebrafish testis ( Danio rerio )

(2017) Tuğba Kotil et al.   MICRON

Fullerene nanoparticle in dermatological and cosmetic applications

(2017) S. Zeinab Mousavi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Activation of autophagy by elevated reactive oxygen species rather than released silver ions promotes cytotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in hematopoietic cells

(2017) Lingying Zhu et al.   Nanoscale

The Impact of Novel Assessment Methodologies in Toxicology on Green Chemistry and Chemical Alternatives

(2017) Ivan Rusyn et al.   TOXICOLOGICAL SCIENCES

Toward a systematic exploration of nano-bio interactions

(2017) Xue Bai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nanoparticles: Properties, applications and toxicities

(2017) Ibrahim Khan et al.   Arabian Journal of Chemistry

Silver nanoparticles of different sizes induce a mixed type of programmed cell death in human pancreatic ductal adenocarcinoma

(2017) Ewelina Zielinska et al.   Oncotarget

C. elegans-on-a-chip for in situ and in vivo Ag nanoparticles’ uptake and toxicity assay

(2017) Jin Ho Kim et al.   Scientific Reports

Exploring Autophagy in Drosophila

(2017) Péter Lőrincz et al.   Cells

Studying Autophagy in Zebrafish

(2017) Benan Mathai et al.   Cells

Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

(2017) Sarah Bettini et al.   Scientific Reports

Effect of Size and Surface Charge of Gold Nanoparticles on their Skin Permeability: A Molecular Dynamics Study

(2017) Rakesh Gupta et al.   Scientific Reports

Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors

(2016) Ashley A. George et al.   BIOESSAYS

Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling

(2016) Caixia Guo et al.   International Journal of Nanomedicine

Dealing with nanosafety around the globe—Regulation vs. innovation

(2016) Matthias G. Wacker et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

TheC. elegansmodel in toxicity testing

(2016) Piper Reid Hunt   JOURNAL OF APPLIED TOXICOLOGY

Nanoliposomes: Synthesis methods and applications in cosmetics

(2016) Zohreh Fakhravar et al.   Journal of Cosmetic and Laser Therapy

Engineered Nanoparticles as Potential Food Contaminants and Their Toxicity to Caco-2 Cells

(2016) Xiaomo Mao et al.   JOURNAL OF FOOD SCIENCE

Mechanisms of silver nanoparticle-induced toxicity and important role of autophagy

(2016) Bin-Hsu Mao et al.   Nanotoxicology

Developmental Toxicity of Zinc Oxide Nanoparticles to Zebrafish (Danio rerio): A Transcriptomic Analysis

(2016) Jin Soo Choi et al.   PLoS One

Alternative Testing Strategies for Nanomaterials: State of the Science and Considerations for Risk Analysis

(2016) J. A. Shatkin et al.   RISK ANALYSIS

Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent

(2016) Anurag R. Mishra et al.   TOXICOLOGICAL SCIENCES

Photodynamic N-TiO2 Nanoparticle Treatment Induces Controlled ROS-mediated Autophagy and Terminal Differentiation of Leukemia Cells

(2016) Mohammad Amin Moosavi et al.   Scientific Reports

Dose-dependent autophagic effect of titanium dioxide nanoparticles in human HaCaT cells at non-cytotoxic levels

(2016) Viviana R. Lopes et al.   JOURNAL OF NANOBIOTECHNOLOGY

Zebrafish: A complete animal model to enumerate the nanoparticle toxicity

(2016) Chiranjib Chakraborty et al.   JOURNAL OF NANOBIOTECHNOLOGY

C. elegans as a tool for in vivo nanoparticle assessment

(2015) L. Gonzalez-Moragas et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Genotoxicity assessment of TiO2 nanoparticles in the teleost Danio rerio

(2015) Lucia Rocco et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

A rapid in vivo zebrafish model to elucidate oxidative stress-mediated PCB126-induced apoptosis and developmental toxicity

(2015) Han Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

TiO2 Nanoparticle Exposure Decreases Spermatogenesis via Biochemical Dysfunctions in the Testis of Male Mice

(2015) Fashui Hong et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Autophagy in zebrafish

(2015) Máté Varga et al.   METHODS

Nanotoxicity: The Toxicity Research Progress of Metal and Metal- Containing Nanoparticles

(2015) Lingling Ding et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Silver nanoparticles impede phorbol myristate acetate-induced monocyte–macrophage differentiation and autophagy

(2015) Yingying Xu et al.   Nanoscale

Impact of anatase and rutile titanium dioxide nanoparticles on uptake carriers and efflux pumps in Caco-2 gut epithelial cells

(2015) M. Dorier et al.   Nanoscale

Towards an alternative testing strategy for nanomaterials used in nanomedicine: Lessons from NanoTEST

(2015) M. Dusinska et al.   Nanotoxicology

Alternatives to animal testing: A review

(2015) Sonali K. Doke et al.   SAUDI PHARMACEUTICAL JOURNAL

The SEURAT-1 approach towards animal free human safety assessment

(2015) Tilman Gocht   ALTEX-Alternatives to Animal Experimentation

Antitumor Activities of Metal Oxide Nanoparticles

(2015) Maria Vinardell et al.   Nanomaterials

Less Is More: Long-Term in Vitro Exposure to Low Levels of Silver Nanoparticles Provides New Insights for Nanomaterial Evaluation

(2014) Kristen K. Comfort et al.   ACS Nano

Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry

(2014) Ling Wu et al.   ACS Nano

Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts

(2014) Yu-Hsuan Lee et al.   BIOMATERIALS

The influence of lysosomal stability of silver nanomaterials on their toxicity to human cells

(2014) Magdiel Inggrid Setyawati et al.   BIOMATERIALS

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

(2014) Douglas R. Green et al.   CELL

Acute exposure to ZnO nanoparticles induces autophagic immune cell death

(2014) Brandon M. Johnson et al.   Nanotoxicology

Drosophila melanogasteras a model organism to study nanotoxicity

(2014) Cynthia Ong et al.   Nanotoxicology

Physicochemical characteristics of nanomaterials that affect pulmonary inflammation

(2014) Hedwig M Braakhuis et al.   Particle and Fibre Toxicology

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

(2013) Freya Joris et al.   CHEMICAL SOCIETY REVIEWS

Zebrafish as a model system to study toxicology

(2013) Yu-Jie Dai et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models

(2013) Tsun-Jen Cheng et al.   International Journal of Nanomedicine

A systematic genome-wide analysis of zebrafish protein-coding gene function

(2013) Ross N. W. Kettleborough et al.   NATURE

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Bioenergetic failure correlates with autophagy and apoptosis in rat liver following silver nanoparticle intraperitoneal administration

(2013) Tzu-Ying Lee et al.   Particle and Fibre Toxicology

Silver nanoparticles induce endoplasmatic reticulum stress response in zebrafish

(2013) Verena Christen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening

(2012) Andre Nel et al.   ACCOUNTS OF CHEMICAL RESEARCH

Applications of Nanotechnology in Dermatology

(2012) Lisa A. DeLouise   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Surface functionalities of gold nanoparticles impact embryonic gene expression responses

(2012) Lisa Truong et al.   Nanotoxicology

Exposure to Titanium Dioxide Nanoparticles Induces Autophagy in Primary Human Keratinocytes

(2012) Yun Zhao et al.   Small

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Skin photoprotection improvement: Synergistic interaction between lipid nanoparticles and organic UV filters

(2011) S. Nikolić et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Safety Evaluation of Sunscreen Formulations Containing Titanium Dioxide and Zinc Oxide Nanoparticles in UVB Sunburned Skin: An In Vitro and In Vivo Study

(2011) N. A. Monteiro-Riviere et al.   TOXICOLOGICAL SCIENCES

Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications

(2010) John W Rasmussen et al.   Expert Opinion on Drug Delivery

Identification of an Autophagy Defect in Smokers' Alveolar Macrophages

(2010) M. M. Monick et al.   JOURNAL OF IMMUNOLOGY

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Application of Nanotechnology in Cosmetics

(2010) Li Mu et al.   PHARMACEUTICAL RESEARCH

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

(2010) Z.-H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro assessments of nanomaterial toxicity

(2009) Clinton F. Jones et al.   ADVANCED DRUG DELIVERY REVIEWS

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

The Impact of Toxicity Testing Costs on Nanomaterial Regulation

(2009) Jae-Young Choi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

(2009) Anne Simonsen et al.   JOURNAL OF CELL BIOLOGY

The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

(2009) Y. T. Zheng et al.   JOURNAL OF IMMUNOLOGY

Silver nanoparticles as a new generation of antimicrobials

(2008) Mahendra Rai et al.   BIOTECHNOLOGY ADVANCES

Twenty-Eight-Day Oral Toxicity, Genotoxicity, and Gender-Related Tissue Distribution of Silver Nanoparticles in Sprague-Dawley Rats

(2008) Yong Soon Kim et al.   INHALATION TOXICOLOGY

Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo

(2008) Andrei V. Zvyagin et al.   JOURNAL OF BIOMEDICAL OPTICS

Preferential killing of cancer cells and activated human T cells using ZnO nanoparticles

(2008) Cory Hanley et al.   NANOTECHNOLOGY

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE

Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: A rapid in vivo screening method for nanotoxicity

(2008) Ronghui Lei et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY