Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells

Immune Regulation of Metabolic Homeostasis in Health and Disease

(2015) Jonathan R. Brestoff et al.   CELL

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

(2015) Dmitriy Kolodin et al.   Cell Metabolism

B cells expressing IFN-γ suppress Treg-cell differentiation and promote autoimmune experimental arthritis

(2015) Susan A. Olalekan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance

(2015) Jonathan M. Han et al.   JOURNAL OF IMMUNOLOGY

Prostate cancer: 4 big questions

(2015) Richard Hodson   NATURE

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential

(2014) Daniela Cipolletta   IMMUNOLOGY

Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation

(2014) Zheng Yin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

(2014) Lydia Lynch et al.   NATURE IMMUNOLOGY

An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4+ T Cells Controls Obesity-Induced Inflammation

(2014) Kae Won Cho et al.   Cell Reports

Raggin’ on T-bet

(2013) Richard M. Locksley   Cell Metabolism

Improved Insulin Sensitivity despite Increased Visceral Adiposity in Mice Deficient for the Immune Cell Transcription Factor T-bet

(2013) Emilie Stolarczyk et al.   Cell Metabolism

Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation

(2013) Tuo Deng et al.   Cell Metabolism

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis

(2013) Roland Klingenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid Deletion of Nuclear Factor Erythroid 2−Related Factor 2 Increases Atherosclerosis and Liver Injury

(2012) Alan R. Collins et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue

(2012) M Zeyda et al.   INTERNATIONAL JOURNAL OF OBESITY

Natural killer T cells in adipose tissue prevent insulin resistance

(2012) Henk S. Schipper et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells

(2012) J. Y. Huh et al.   MOLECULAR AND CELLULAR BIOLOGY

OX40 signaling favors the induction of TH9 cells and airway inflammation

(2012) Xiang Xiao et al.   NATURE IMMUNOLOGY

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

(2011) Kathrin Eller et al.   DIABETES

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

(2011) Xingguang Liu et al.   NATURE IMMUNOLOGY

Visceral Adipose Inflammation in Obesity Is Associated with Critical Alterations in Tregulatory Cell Numbers

(2011) Jeffrey Deiuliis et al.   PLoS One

Human Primary Adipocytes Exhibit Immune Cell Function: Adipocytes Prime Inflammation Independent of Macrophages

(2011) Kees Meijer et al.   PLoS One

Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice

(2010) Mehmet M. Altintas et al.   JOURNAL OF LIPID RESEARCH

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

(2010) Y. Ilan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

T-lymphocyte Infiltration in Visceral Adipose Tissue

(2008) Ulrich Kintscher et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Interferon-γ, a Th1 Cytokine, Regulates Fat Inflammation

(2008) Viviane Zorzanelli Rocha et al.   CIRCULATION RESEARCH