The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Immune cell extracellular vesicles and their mitochondrial content decline with ageing

(2020) Xin Zhang et al.   Immunity & Ageing

The Histone Code of Senescence

(2020) Harikrishnareddy Paluvai et al.   Cells

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Senolytics and senostatics as adjuvant tumour therapy

(2019) Susan Short et al.   EBioMedicine

Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes

(2019) Peter J. Thompson et al.   Cell Metabolism

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

Exosomes as Emerging Pro-Tumorigenic Mediators of the Senescence-Associated Secretory Phenotype

(2019) Rekha Jakhar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcriptome signature of cellular senescence

(2019) Gabriel Casella et al.   NUCLEIC ACIDS RESEARCH

Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

(2019) Michela Borghesan et al.   Cell Reports

SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

(2019) Christopher D. Wiley et al.   Cell Reports

Biomarkers in the path from cellular senescence to frailty

(2019) Marta Zampino et al.   EXPERIMENTAL GERONTOLOGY

Undulating changes in human plasma proteome profiles across the lifespan

(2019) Benoit Lehallier et al.   NATURE MEDICINE

Classification of mouse B cell types using surfaceome proteotype maps

(2019) Marc van Oostrum et al.   Nature Communications

Emerging roles of extracellular vesicles in cellular senescence and aging

(2018) Masaki Takasugi   AGING CELL

Plasma proteomic signature of age in healthy humans

(2018) Toshiko Tanaka et al.   AGING CELL

Musculoskeletal senescence: a moving target ready to be eliminated

(2018) Marjolein P Baar et al.   CURRENT OPINION IN PHARMACOLOGY

Cell-surface proteomics for the identification of novel therapeutic targets in cancer

(2018) Laura Kuhlmann et al.   Expert Review of Proteomics

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Simultaneous Quantification of the Acetylome and Succinylome by ‘One-Pot’ Affinity Enrichment

(2018) Nathan Basisty et al.   PROTEOMICS

The induction of the fibroblast extracellular senescence metabolome is a dynamic process

(2018) Emma N. L. James et al.   Scientific Reports

Caloric restriction and cellular senescence

(2018) Luigi Fontana et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The in silico human surfaceome

(2018) Damaris Bausch-Fluck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical applications of quantitative proteomics using targeted and untargeted data-independent acquisition techniques

(2017) Jesse G. Meyer et al.   Expert Review of Proteomics

Identification of senescent cell surface targetable protein DPP4

(2017) Kyoung Mi Kim et al.   GENES & DEVELOPMENT

Experimental Design in Clinical ‘Omics Biomarker Discovery

(2017) Jenny Forshed   JOURNAL OF PROTEOME RESEARCH

A Strategy to Combine Sample Multiplexing with Targeted Proteomics Assays for High-Throughput Protein Signature Characterization

(2017) Brian K. Erickson et al.   MOLECULAR CELL

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Quantitative, multiplexed workflow for deep analysis of human blood plasma and biomarker discovery by mass spectrometry

(2017) Hasmik Keshishian et al.   Nature Protocols

Ancient Regulatory Role of Lysine Acetylation in Central Metabolism

(2017) Ernesto S. Nakayasu et al.   mBio

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

(2017) Masaki Takasugi et al.   Nature Communications

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

(2017) Ben C. Collins et al.   Nature Communications

Protein and chemotherapy profiling of extracellular vesicles harvested from therapeutic induced senescent triple negative breast cancer cells

(2017) E L Kavanagh et al.   Oncogenesis

Small molecule compounds that induce cellular senescence

(2016) Nadezhda V. Petrova et al.   AGING CELL

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses

(2016) Servet Özcan et al.   Aging-US

Placental membrane aging and HMGB1 signaling associated with human parturition

(2016) Ramkumar Menon et al.   Aging-US

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease

(2016) Kai C. Wollert et al.   CLINICAL CHEMISTRY

A Roadmap to Successful Clinical Proteomics

(2016) Ian Wright et al.   CLINICAL CHEMISTRY

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

(2016) Marissa J. Schafer et al.   DIABETES

Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype

(2016) Nicolas Malaquin et al.   EXPERIMENTAL GERONTOLOGY

Effects of senescent lens epithelial cells on the severity of age-related cortical cataract in humans

(2016) Qiuli Fu et al.   MEDICINE

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

Cerebrospinal Fluid Stanniocalcin-1 as a Biomarker for Alzheimer’s Disease and Other Neurodegenerative Disorders

(2016) Pashtun Shahim et al.   NEUROMOLECULAR MEDICINE

Advances in targeted proteomics and applications to biomedical research

(2016) Tujin Shi et al.   PROTEOMICS

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells

(2016) Hyejin Park et al.   Oncotarget

Concise Review: Cell SurfaceN-Linked Glycoproteins as Potential Stem Cell Markers and Drug Targets

(2016) Kenneth R. Boheler et al.   Stem Cells Translational Medicine

Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma

(2016) Yu-Kuei Chen et al.   Scientific Reports

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium

(2015) C.-y. Hsu et al.   Clinical Journal of the American Society of Nephrology

Of Flies, Mice, and Men: Evolutionarily Conserved Tissue Damage Responses and Aging

(2015) Joana Neves et al.   DEVELOPMENTAL CELL

Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease

(2015) Emma L. James et al.   JOURNAL OF PROTEOME RESEARCH

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells

(2015) Michael C. Velarde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes in bodily fluids are a highly stable resource of disease biomarkers

(2015) Stephanie Boukouris et al.   Proteomics Clinical Applications

Using data-independent, high-resolution mass spectrometry in protein biomarker research: Perspectives and clinical applications

(2015) Tatjana Sajic et al.   Proteomics Clinical Applications

Stanniocalcin-1, a new biomarker of glioma progression, is associated with prognosis of patients

(2015) Jingyuan Su et al.   TUMOR BIOLOGY

The oncogenetic role of stanniocalcin 1 in lung adenocarcinoma: a promising serum candidate biomarker for tracking lung adenocarcinoma progression

(2015) Yu-Zhen Du et al.   TUMOR BIOLOGY

A Mass Spectrometric-Derived Cell Surface Protein Atlas

(2015) Damaris Bausch-Fluck et al.   PLoS One

STC1 expression is associated with tumor growth and metastasis in breast cancer

(2014) Andy C-M Chang et al.   CLINICAL & EXPERIMENTAL METASTASIS

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding

(2014) Timo Effenberger et al.   FASEB JOURNAL

Analytical Validation Considerations of Multiplex Mass-Spectrometry-Based Proteomic Platforms for Measuring Protein Biomarkers

(2014) Emily S. Boja et al.   JOURNAL OF PROTEOME RESEARCH

Four Areas of Engagement Requiring Strengthening in Modern Proteomics Today

(2014) Thomas E. Fehniger et al.   JOURNAL OF PROTEOME RESEARCH

Stanniocalcin-1 Inhibits Renal Ischemia/Reperfusion Injury via an AMP-Activated Protein Kinase-Dependent Pathway

(2014) J. S.-C. Pan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach

(2014) Steven A. Carr et al.   MOLECULAR & CELLULAR PROTEOMICS

Characterization of novel markers of senescence and their prognostic potential in cancer

(2014) M Althubiti et al.   Cell Death & Disease

HIV protease inhibitors induce senescence and alter osteoblastic potential of human bone marrow mesenchymal stem cells: beneficial effect of pravastatin

(2013) Sandra J. Hernandez-Vallejo et al.   AGING CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Biomarkers of Cardiovascular Stress and Incident Chronic Kidney Disease

(2013) J. E. Ho et al.   CLINICAL CHEMISTRY

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

GDF-15 for Prognostication of Cardiovascular and Cancer Morbidity and Mortality in Men

(2013) Lars Wallentin et al.   PLoS One

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Is cellular senescence an example of antagonistic pleiotropy?

(2012) Stefano Giaimo et al.   AGING CELL

Clinical and Genetic Correlates of Growth Differentiation Factor 15 in the Community

(2012) J. E. Ho et al.   CLINICAL CHEMISTRY

Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis

(2012) Ludovic C. Gillet et al.   MOLECULAR & CELLULAR PROTEOMICS

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Secreted proteins as a fundamental source for biomarker discovery

(2012) Miroslava Stastna et al.   PROTEOMICS

Growth-Differentiation Factor-15 Is a Robust, Independent Predictor of 11-Year Mortality Risk in Community-Dwelling Older Adults

(2011) Lori B. Daniels et al.   CIRCULATION

Painting a Moving Picture: Large-Scale Proteomics Efforts and Their Potential for Changing Patient Care

(2011) A. N. Hoofnagle et al.   CLINICAL CHEMISTRY

Association of Growth Differentiation Factor-15 with Coronary Atherosclerosis and Mortality in a Young, Multiethnic Population: Observations from the Dallas Heart Study

(2011) A. Rohatgi et al.   CLINICAL CHEMISTRY

Doxorubicin-Induced Platelet Procoagulant Activities: An Important Clue for Chemotherapy-Associated Thrombosis

(2011) Se-Hwan Kim et al.   TOXICOLOGICAL SCIENCES

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Premature Senescence of Vascular Cells Is Induced by HIV Protease Inhibitors

(2010) Chloé Lefèvre et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cellular senescence: putting the paradoxes in perspective

(2010) Judith Campisi   CURRENT OPINION IN GENETICS & DEVELOPMENT

Exosomes/microvesicles as a mechanism of cell-to-cell communication

(2010) Giovanni Camussi et al.   KIDNEY INTERNATIONAL

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Physical Exercise Prevents Cellular Senescence in Circulating Leukocytes and in the Vessel Wall

(2009) Christian Werner et al.   CIRCULATION

Protein-Based Multiplex Assays: Mock Presubmissions to the US Food and Drug Administration

(2009) F. E. Regnier et al.   CLINICAL CHEMISTRY

Analytical Validation of Protein-Based Multiplex Assays: A Workshop Report by the NCI-FDA Interagency Oncology Task Force on Molecular Diagnostics

(2009) H. Rodriguez et al.   CLINICAL CHEMISTRY

Matrix Metalloproteinases As Novel Biomarker s and Potential Therapeutic Targets in Human Cancer

(2009) Roopali Roy et al.   JOURNAL OF CLINICAL ONCOLOGY

Senescence-Associated Exosome Release from Human Prostate Cancer Cells

(2008) B. D. Lehmann et al.   CANCER RESEARCH

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

MMP1 and MMP7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis

(2008) Ivan O Rosas et al.   PLOS MEDICINE