Posttranslational modifications regulate HIPK2, a driver of proliferative diseases

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation

(2013) Francesca Siepi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Chromosomal instability and cancer: a complex relationship with therapeutic potential

(2012) Samuel F. Bakhoum et al.   JOURNAL OF CLINICAL INVESTIGATION

HIPK2 Controls Cytokinesis and Prevents Tetraploidization by Phosphorylating Histone H2B at the Midbody

(2012) Cinzia Rinaldo et al.   MOLECULAR CELL

A Redox-Regulated SUMO/Acetylation Switch of HIPK2 Controls the Survival Threshold to Oxidative Stress

(2012) Laureano de la Vega et al.   MOLECULAR CELL

A systems approach identifies HIPK2 as a key regulator of kidney fibrosis

(2012) Yuanmeng Jin et al.   NATURE MEDICINE

HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

(2012) Vera V. Saul et al.   Journal of Molecular Cell Biology

Tissue Microarray Cytometry Reveals Positive Impact of Homeodomain Interacting Protein Kinase 2 in Colon Cancer Survival Irrespective of p53 Function

(2011) Isabelle Soubeyran et al.   AMERICAN JOURNAL OF PATHOLOGY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Homeodomain Interacting Protein Kinase 2 Regulates Postnatal Development of Enteric Dopaminergic Neurons and Glia via BMP Signaling

(2011) A. Chalazonitis et al.   JOURNAL OF NEUROSCIENCE

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

(2011) J-H Mao et al.   ONCOGENE

The Loss of the p53 Activator HIPK2 Is Responsible for Galectin-3 Overexpression in Well Differentiated Thyroid Carcinomas

(2011) Luca Lavra et al.   PLoS One

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin

(2011) A. Grison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of nuclear HIPK2 localization and function by a SUMO interaction motif

(2010) Laureano de la Vega et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation

(2010) S. M. Hattangadi et al.   BLOOD

Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53

(2010) Ki Sa Sung et al.   EXPERIMENTAL CELL RESEARCH

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis

(2010) Toshihiro Inoue et al.   FEBS LETTERS

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells

(2010) R Puca et al.   ONCOGENE

Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation

(2009) Jutta Moehlenbrink et al.   CANCER LETTERS

Targeted Disruption of the Murine Homeodomain-Interacting Protein Kinase-2 Causes Growth DeficiencyIn Vivoand Cell Cycle ArrestIn Vitro

(2009) Francesco Trapasso et al.   DNA AND CELL BIOLOGY

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

(2009) J. Yu et al.   NEUROLOGY

Liver fibrosis

(2008) Karen Wallace et al.   BIOCHEMICAL JOURNAL

HIPKs: Jack of all trades in basic nuclear activities

(2008) Cinzia Rinaldo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PEBP2- /CBF- -dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

(2008) H.-J. Wee et al.   BLOOD

Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho

(2008) Wendy Lee et al.   DEVELOPMENTAL BIOLOGY

PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation

(2008) Y. Shima et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR

(2008) Melanie Winter et al.   NATURE CELL BIOLOGY

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response

(2008) Marco A. Calzado et al.   NATURE CELL BIOLOGY

High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas

(2008) H Deshmukh et al.   ONCOGENE