More than just scanning: the importance of cap-independent mRNA translation initiation for cellular stress response and cancer

The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non‐coding RNA and synonymous mutations

(2016) Sven Diederichs et al.   EMBO Molecular Medicine

Cancer‐specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis

(2016) Marco M Candeias et al.   EMBO REPORTS

Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)-mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat Glioblastoma

(2016) Brent Holmes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering the epitranscriptome: A green perspective

(2016) Alice Burgess et al.   Journal of Integrative Plant Biology

Roles of different IRES-dependent FGF2 isoforms in the acquisition of the major aggressive features of human metastatic melanoma

(2016) Elena Andreucci et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

DHX29 reduces leaky scanning through an upstream AUG codon regardless of its nucleotide context

(2016) Vera P. Pisareva et al.   NUCLEIC ACIDS RESEARCH

Principles of start codon recognition in eukaryotic translation initiation

(2016) Christoffer Lind et al.   NUCLEIC ACIDS RESEARCH

Efficient Translation of Pelargonium line pattern virus RNAs Relies on a TED-Like 3´-Translational Enhancer that Communicates with the Corresponding 5´-Region through a Long-Distance RNA-RNA Interaction

(2016) Marta Blanco-Pérez et al.   PLoS One

eIF4B stimulates translation of long mRNAs with structured 5′ UTRs and low closed-loop potential but weak dependence on eIF4G

(2016) Neelam Dabas Sen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome-wide distribution and function of RNA hydroxymethylcytosine

(2016) B. Delatte et al.   SCIENCE

Systematic discovery of cap-independent translation sequences in human and viral genomes

(2016) Shira Weingarten-Gabbay et al.   SCIENCE

PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress

(2016) Céline Philippe et al.   Science Signaling

IRES inhibition induces terminal differentiation and synchronized death in triple-negative breast cancer and glioblastoma cells

(2016) Christos Vaklavas et al.   TUMOR BIOLOGY

PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress

(2016) Céline Philippe et al.   Science Signaling

Translating the Genome in Time and Space: Specialized Ribosomes, RNA Regulons, and RNA-Binding Proteins

(2015) Zhen Shi et al.   Annual Review of Cell and Developmental Biology

β-Catenin expression is regulated by an IRES-dependent mechanism and stimulated by paclitaxel in human ovarian cancer cells

(2015) Qianyun Fu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

G-quadruplexes mediate local translation in neurons

(2015) James P.R. Schofield et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Myc induced replicative stress response: How to cope with it and exploit it

(2015) Sara Rohban et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Cap-dependent, scanning-free translation initiation mechanisms

(2015) Ora Haimov et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Stress-mediated translational control in cancer cells

(2015) Gabriel Leprivier et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

m6A: A novel hallmark of translation

(2015) Jun Zhou et al.   CELL CYCLE

Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs

(2015) K-S Hsu et al.   CELL DEATH AND DIFFERENTIATION

Reversible induction of translational isoforms of p53 in glucose deprivation

(2015) D Khan et al.   CELL DEATH AND DIFFERENTIATION

RNA G-Quadruplex: The New Potential Targets for Therapy

(2015) Shi-Ke Wang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Overexpression of FGF9 in Prostate Epithelial Cells Augments Reactive Stroma Formation and Promotes Prostate Cancer Progression

(2015) Yanqing Huang et al.   International Journal of Biological Sciences

Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5′ Untranslated Region (UTR) of Its mRNA

(2015) Jie Dai et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Unique 5′ Translation Element Discovered in Triticum Mosaic Virus

(2015) Robyn Roberts et al.   JOURNAL OF VIROLOGY

Deregulation of Internal Ribosome Entry Site-Mediated p53 Translation in Cancer Cells with Defective p53 Response to DNA Damage

(2015) Marie-Jo Halaby et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival

(2015) Tao Liu et al.   Molecular Cancer

Initiation of translation in bacteria by a structured eukaryotic IRES RNA

(2015) Timothy M. Colussi et al.   NATURE

Structure of mammalian eIF3 in the context of the 43S preinitiation complex

(2015) Amedee des Georges et al.   NATURE

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation

(2015) Noa Liberman et al.   NUCLEIC ACIDS RESEARCH

Therapeutic potential of targeting IRES-dependent c-myc translation in multiple myeloma cells during ER stress

(2015) Y Shi et al.   ONCOGENE

Cis-regulatory RNA elements that regulate specialized ribosome activity

(2015) Shifeng Xue et al.   RNA Biology

Regulation of humanPTCH1bexpression by different 5' untranslated regioncis-regulatory elements

(2015) Petar Ozretić et al.   RNA Biology

Stabilization of the G-quadruplex at the VEGF IRES represses cap-independent translation

(2015) Anne Cammas et al.   RNA Biology

3′UTRs of carmoviruses

(2015) Anne E. Simon   VIRUS RESEARCH

The 5′-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding

(2015) Alessandra Bisio et al.   Oncotarget

Structural insights into viral IRES-dependent translation mechanisms

(2015) Gloria Lozano et al.   Current Opinion in Virology

Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage

(2015) Marie-Jo Halaby et al.   Biomed Research International

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Exploring Internal Ribosome Entry Sites as Therapeutic Targets

(2015) Anton A. Komar et al.   Frontiers in Oncology

Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?

(2015) Martin Holcik   Frontiers in Oncology

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

Nucleolin enhances internal ribosomal entry site (IRES)-mediated translation of Sp1 in tumorigenesis

(2014) Chia-Yang Hung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining

(2014) B. Kuhle et al.   EMBO JOURNAL

Functional and Biochemical Characterization of Human Eukaryotic Translation Initiation Factor 3 in Living Cells

(2014) Susan Wagner et al.   MOLECULAR AND CELLULAR BIOLOGY

HDMX Folds the Nascent p53 mRNA following Activation by the ATM Kinase

(2014) Laurence Malbert-Colas et al.   MOLECULAR CELL

RNA regulons in Hox 5′ UTRs confer ribosome specificity to gene regulation

(2014) Shifeng Xue et al.   NATURE

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

(2014) Yang Wang et al.   NATURE CELL BIOLOGY

Translational control of immune responses: from transcripts to translatomes

(2014) Ciriaco A Piccirillo et al.   NATURE IMMUNOLOGY

eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning

(2014) Vera P. Pisareva et al.   NUCLEIC ACIDS RESEARCH

IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1

(2014) M D Faye et al.   ONCOGENE

The Polyadenylation Factor Subunit CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30: A Key Factor of Programmed Cell Death and a Regulator of Immunity in Arabidopsis

(2014) Q. Bruggeman et al.   PLANT PHYSIOLOGY

Human Transporter Database: Comprehensive Knowledge and Discovery Tools in the Human Transporter Genes

(2014) Adam Y. Ye et al.   PLoS One

Hypoxia Induces VEGF-C Expression in Metastatic Tumor Cells via a HIF-1α-Independent Translation-Mediated Mechanism

(2014) Florent Morfoisse et al.   Cell Reports

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1

(2014) B. P. Tsai et al.   Open Biology

3′ Cap-Independent Translation Enhancers of Plant Viruses

(2013) Anne E. Simon et al.   Annual Review of Microbiology

Understanding MYC-driven aggressive B-cell lymphomas: pathogenesis and classification

(2013) G. Ott et al.   BLOOD

p53 Acts as a Safeguard of Translational Control by Regulating Fibrillarin and rRNA Methylation in Cancer

(2013) Virginie Marcel et al.   CANCER CELL

Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29

(2013) Yaser Hashem et al.   CELL

The mechanism of translation initiation on Type 1 picornavirus IRESs

(2013) Trevor R Sweeney et al.   EMBO JOURNAL

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation

(2013) M. D. Jennings et al.   GENES & DEVELOPMENT

Human Eukaryotic Initiation Factor 4G (eIF4G) Protein Binds to eIF3c, -d, and -e to Promote mRNA Recruitment to the Ribosome

(2013) Nancy Villa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The initiation of mammalian protein synthesis and mRNA scanning mechanism

(2013) Ivan B. Lomakin et al.   NATURE

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation

(2013) T.-M. Chen et al.   NUCLEIC ACIDS RESEARCH

VEGF-A mRNA processing, stability and translation: a paradigm for intricate regulation of gene expression at the post-transcriptional level

(2013) T. Arcondeguy et al.   NUCLEIC ACIDS RESEARCH

The translation initiation factor DAP5 promotes IRES-driven translation of p53 mRNA

(2013) S Weingarten-Gabbay et al.   ONCOGENE

Overexpression of Arginine Transporter CAT-1 Is Associated with Accumulation of L-Arginine and Cell Growth in Human Colorectal Cancer Tissue

(2013) Ying Lu et al.   PLoS One

Deciphering the rules by which 5'-UTR sequences affect protein expression in yeast

(2013) S. Dvir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Current Status of Vertebrate Cellular mRNA IRESs

(2013) R. J. Jackson   Cold Spring Harbor Perspectives in Biology

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease

(2013) Cristina Barbosa et al.   PLoS Genetics

Translational reprogramming in cellular stress response

(2013) Botao Liu et al.   Wiley Interdisciplinary Reviews-RNA

hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress

(2012) Fabrizio Damiano et al.   BIOCHEMICAL JOURNAL

Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response

(2012) Kate Petersen Shay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis

(2012) Weihua Li et al.   CELL CYCLE

Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs

(2012) Encarnación Martínez-Salas et al.   COMPARATIVE AND FUNCTIONAL GENOMICS

RNA Binding Protein/RNA Element Interactions and the Control of Translation

(2012) Xavier Pichon et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The 5′ untranslated region of Apaf-1 mRNA directs translation under apoptosis conditions via a 5′ end-dependent scanning mechanism

(2012) Dmitri E. Andreev et al.   FEBS LETTERS

The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines

(2012) Claudia M.J. Lucero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Specialized ribosomes: a new frontier in gene regulation and organismal biology

(2012) Shifeng Xue et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A mechanistic overview of translation initiation in eukaryotes

(2012) Colin Echeverría Aitken et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel mechanism of eukaryotic translation initiation that is neither m7G-cap-, nor IRES-dependent

(2012) Ilya M. Terenin et al.   NUCLEIC ACIDS RESEARCH

5'-UTR RNA G-quadruplexes: translation regulation and targeting

(2012) A. Bugaut et al.   NUCLEIC ACIDS RESEARCH

Effect of a natural mutation in the 5′ untranslated region on the translational control of p53 mRNA

(2012) D Khan et al.   ONCOGENE

Annexin A2 and PSF proteins interact with p53 IRES and regulate translation of p53 mRNA

(2012) Arandkar Sharathchandra et al.   RNA Biology

Principles of Translational Control: An Overview

(2012) J. W. B. Hershey et al.   Cold Spring Harbor Perspectives in Biology

Translational Control in Cancer Etiology

(2012) D. Ruggero   Cold Spring Harbor Perspectives in Biology

The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges

(2012) A. G. Hinnebusch et al.   Cold Spring Harbor Perspectives in Biology

Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning

(2011) Nadya Kondrashov et al.   CELL

Inflammatory breast cancer cells are constitutively adapted to hypoxia

(2011) Deborah Silvera et al.   CELL CYCLE

Cellular IRES-mediated translation

(2011) Anton A Komar et al.   CELL CYCLE

Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer

(2011) Constance Lay Lay Saw et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Transcription and translation in a package deal: The TISU paradigm

(2011) Rivka Dikstein   GENE

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

(2011) N. Dai et al.   GENES & DEVELOPMENT

Far upstream element binding protein 1 activates translation of p27Kip1 mRNA through its internal ribosomal entry site

(2011) Yuhuan Zheng et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Duplex Unwinding and ATPase Activities of the DEAD-Box Helicase eIF4A Are Coupled by eIF4G and eIF4B

(2011) Ali R. ze et al.   JOURNAL OF MOLECULAR BIOLOGY

La Autoantigen Mediates Oxidant Induced De Novo Nrf2 Protein Translation

(2011) Jack Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway

(2011) Shiu Hwa Yeh et al.   NUCLEIC ACIDS RESEARCH

Unique translation initiation of mRNAs-containing TISU element

(2011) Rofa Elfakess et al.   NUCLEIC ACIDS RESEARCH

IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress

(2011) Nehal Thakor et al.   NUCLEIC ACIDS RESEARCH

Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site

(2010) Fabrizio Damiano et al.   BIOCHEMICAL JOURNAL

Post-transcriptional and post-translational regulation of Bcl2: Figure 1

(2010) Shaun Willimott et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of protein synthesis and the role of eIF3 in cancer

(2010) John W.B. Hershey   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Novel Dyskerin-Mediated Mechanism of p53 Inactivation through Defective mRNA Translation

(2010) Lorenzo Montanaro et al.   CANCER RESEARCH

Polypyrimidine tract binding protein regulates IRES-mediated translation of p53 isoforms

(2010) Richa Grover et al.   CELL CYCLE

Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita

(2010) Cristian Bellodi et al.   EMBO JOURNAL

PI3K-mTORC1 Attenuates Stress Response by Inhibiting Cap-independent Hsp70 Translation

(2010) Jun Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An RNA G-Quadruplex Is Essential for Cap-Independent Translation Initiation in Human VEGF IRES

(2010) Mark J. Morris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cap- and IRES-independent scanning mechanism of translation initiation as an alternative to the concept of cellular IRESs

(2010) Ivan N. Shatsky et al.   MOLECULES AND CELLS

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

5'-UTR G-quadruplex structures acting as translational repressors

(2010) J.-D. Beaudoin et al.   NUCLEIC ACIDS RESEARCH

Distinct 5′ UTRs regulate XIAP expression under normal growth conditions and during cellular stress

(2010) Alura Riley et al.   NUCLEIC ACIDS RESEARCH

Repression of Translation of Human Estrogen Receptor α by G-Quadruplex Formation

(2009) Graham D. Balkwill et al.   BIOCHEMISTRY

IRES-induced conformational changes in the ribosome and the mechanism of translation initiation by internal ribosomal entry

(2009) Christopher U.T. Hellen   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Structural and functional diversity of viral IRESes

(2009) Laurent Balvay et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response

(2009) T E Graber et al.   CELL DEATH AND DIFFERENTIATION

Toward a structural understanding of IRES RNA function

(2009) Megan E Filbin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cellular Signal Transduction of the Hypoxia Response

(2009) K. Nakayama   JOURNAL OF BIOCHEMISTRY

The hnRNA-Binding Proteins hnRNP L and PTB Are Required for Efficient Translation of the Cat-1 Arginine/Lysine Transporter mRNA during Amino Acid Starvation

(2009) M. Majumder et al.   MOLECULAR AND CELLULAR BIOLOGY

Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer

(2009) Deborah Silvera et al.   NATURE CELL BIOLOGY

Fibroblast growth factor 1 induced during myogenesis by a transcription–translation coupling mechanism

(2009) Caroline Conte et al.   NUCLEIC ACIDS RESEARCH

An internal ribosomal entry site mediates redox-sensitive translation of Nrf2

(2009) Wenge Li et al.   NUCLEIC ACIDS RESEARCH

IRESite—a tool for the examination of viral and cellular internal ribosome entry sites

(2009) Martin Mokrejš et al.   NUCLEIC ACIDS RESEARCH

Alternative Translation ofOCT4by an Internal Ribosome Entry Site and its Novel Function in Stress Response

(2009) Xia Wang et al.   STEM CELLS

Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism

(2008) Regina M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An upstream open reading frame within an IRES controls expression of a specific VEGF-A isoform

(2008) Amandine Bastide et al.   NUCLEIC ACIDS RESEARCH

A Polyadenylation Factor Subunit Implicated in Regulating Oxidative Signaling in Arabidopsis thaliana

(2008) Jingxian Zhang et al.   PLoS One

FGF2 Translationally Induced by Hypoxia Is Involved in Negative and Positive Feedback Loops with HIF-1α

(2008) Caroline Conte et al.   PLoS One

A Translation Initiation Element Specific to mRNAs with Very Short 5′UTR that Also Regulates Transcription

(2008) Rofa Elfakess et al.   PLoS One

Potent activation of FGF-2 IRES-dependent mechanism of translation during brain development

(2008) S. Audigier et al.   RNA

A Cunning Stunt: An Alternative Mechanism of Eukaryotic Translation Initiation

(2008) S. J. Morley et al.   Science Signaling

Viral IRES RNA structures and ribosome interactions

(2008) Jeffrey S. Kieft   TRENDS IN BIOCHEMICAL SCIENCES

Re-programming of translation following cell stress allows IRES-mediated translation to predominate

(2007) Keith A. Spriggs et al.   BIOLOGY OF THE CELL