IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress

Inflammatory breast cancer cells are constitutively adapted to hypoxia

(2011) Deborah Silvera et al.   CELL CYCLE

Cellular IRES-mediated translation

(2011) Anton A Komar et al.   CELL CYCLE

XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38− cells in a phase 1/2 study of patients with relapsed/refractory AML

(2010) Bing Z. Carter et al.   APOPTOSIS

XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease

(2010) R. A. Marsh et al.   BLOOD

Small-molecule pan-IAP antagonists: a patent review

(2010) John A Flygare et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling

(2010) M. A. Skabkin et al.   GENES & DEVELOPMENT

eIF2α Phosphorylation Tips the Balance to Apoptosis during Osmotic Stress

(2010) Elena Bevilacqua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GTP-independent tRNA Delivery to the Ribosomal P-site by a Novel Eukaryotic Translation Factor

(2010) Sergey E. Dmitriev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of eIF2α at Serine 51 Is an Important Determinant of Cell Survival and Adaptation to Glucose Deficiency

(2010) Hala Muaddi et al.   MOLECULAR BIOLOGY OF THE CELL

X-Linked Inhibitor of Apoptosis Protein Inhibits Apoptosis in Inflammatory Breast Cancer Cells with Acquired Resistance to an ErbB1/2 Tyrosine Kinase Inhibitor

(2010) K. M. Aird et al.   MOLECULAR CANCER THERAPEUTICS

Distinct 5′ UTRs regulate XIAP expression under normal growth conditions and during cellular stress

(2010) Alura Riley et al.   NUCLEIC ACIDS RESEARCH

Regulation of XIAP Translation and Induction by MDM2 following Irradiation

(2009) Lubing Gu et al.   CANCER CELL

Phase I/II Trial of AEG35156 X-Linked Inhibitor of Apoptosis Protein Antisense Oligonucleotide Combined With Idarubicin and Cytarabine in Patients With Relapsed or Primary Refractory Acute Myeloid Leukemia

(2009) Aaron D. Schimmer et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Trial of AEG35156 Administered as a 7-Day and 3-Day Continuous Intravenous Infusion in Patients With Advanced Refractory Cancer

(2009) Emma Dean et al.   JOURNAL OF CLINICAL ONCOLOGY

Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer

(2009) Deborah Silvera et al.   NATURE CELL BIOLOGY

Quantitative analysis of ribosome–mRNA complexes at different translation stages

(2009) Nikolay E. Shirokikh et al.   NUCLEIC ACIDS RESEARCH

The XIAP IRES activates 3' cistron expression by inducing production of monocistronic mRNA in the  gal/CAT bicistronic reporter system

(2009) H. A. Saffran et al.   RNA

eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II

(2008) Tatyana V Pestova et al.   EMBO JOURNAL

Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression

(2008) K. M. Aird et al.   MOLECULAR CANCER THERAPEUTICS

Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2

(2008) Ilya M Terenin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE

Splicing mediates the activity of four putative cellular internal ribosome entry sites

(2008) B. T. Baranick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA