MYC and the unfolded protein response in cancer: synthetic lethal partners in crime?

The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum

(2019) G. Elif Karagöz et al.   Cold Spring Harbor Perspectives in Biology

A negative feedback loop between XBP1 and Fbw7 regulates cancer development

(2019) Unbin Chae et al.   Oncogenesis

IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

(2019) Xia Sheng et al.   Nature Communications

A positive role of c-Myc in regulating androgen receptor and its splice variants in prostate cancer

(2019) Shanshan Bai et al.   ONCOGENE

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

(2019) Alessandro Carugo et al.   CANCER CELL

The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response

(2019) A.M. Merlot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endoplasmic reticulum proteostasis control and gastric cancer

(2019) Yu Wang et al.   CANCER LETTERS

Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway

(2019) Yingfeng Xia et al.   CANCER RESEARCH

The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc

(2019) Han Dong et al.   NATURE IMMUNOLOGY

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

(2019) Feven Tameire et al.   NATURE CELL BIOLOGY

Pharmacological targeting of the unfolded protein response for disease intervention

(2019) Claudio Hetz et al.   Nature Chemical Biology

Mutant p53 improves cancer cells’ resistance to endoplasmic reticulum stress by sustaining activation of the UPR regulator ATF6

(2019) Daria Sicari et al.   ONCOGENE

Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer

(2019) Nora Pällmann et al.   ONCOGENE

Dual IRE1 RNase functions dictate glioblastoma development

(2018) Stéphanie Lhomond et al.   EMBO Molecular Medicine

Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer

(2018) Na Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

IRE1α RNase–dependent lipid homeostasis promotes survival in Myc-transformed cancers

(2018) Hong Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response

(2018) LN Huiting et al.   LEUKEMIA

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

(2018) Jordan C. Tsai et al.   SCIENCE

Development of a stress response therapy targeting aggressive prostate cancer

(2018) Hao G. Nguyen et al.   Science Translational Medicine

The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK

(2018) Jing Wang et al.   Oncotarget

MYC-related microRNAs signatures in non-Hodgkin B-cell lymphomas and their relationships with core cellular pathways

(2018) Giorgio Malpeli et al.   Oncotarget

ER stress-related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer

(2018) Chun-Yu Liu et al.   Molecular Oncology

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

(2018) Susan E. Logue et al.   Nature Communications

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance

(2018) Emma Madden et al.   BIOLOGY OF THE CELL

IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

(2018) Minkyung Song et al.   NATURE

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

(2017) Giannicola Genovese et al.   NATURE

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

(2017) Inge M.N. Wortel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer

(2017) Svitlana Tyekucheva et al.   Nature Communications

Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis

(2017) Ming Yue et al.   Cell Reports

Critical role of XBP1 in cancer signalling is regulated by PIN1

(2016) U. Chae et al.   BIOCHEMICAL JOURNAL

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer

(2016) Etienne Dardenne et al.   CANCER CELL

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Genetic requirement forMycland efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer

(2016) Dong-Wook Kim et al.   GENES & DEVELOPMENT

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Prostate cancer and the unfolded protein response

(2016) Margrethe Storm et al.   Oncotarget

Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells

(2016) Mengling Liu et al.   Cell Reports

Splicing and Dicing MYC-Mediated Synthetic Lethality

(2015) Zachary E. Stine et al.   CANCER CELL

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

The endoplasmic reticulum: structure, function and response to cellular signaling

(2015) Dianne S. Schwarz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Divergent androgen regulation of unfolded protein response pathways drives prostate cancer

(2015) X. Sheng et al.   EMBO Molecular Medicine

Targeting the adaptive molecular landscape of castration-resistant prostate cancer

(2015) A. W. Wyatt et al.   EMBO Molecular Medicine

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

Therapeutic potential of targeting IRES-dependent c-myc translation in multiple myeloma cells during ER stress

(2015) Y Shi et al.   ONCOGENE

ER proteostasis addiction in cancer biology: Novel concepts

(2015) Estefanie Dufey et al.   SEMINARS IN CANCER BIOLOGY

Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy

(2015) Feven Tameire et al.   SEMINARS IN CANCER BIOLOGY

Taming of the beast: shaping Myc-dependent amplification

(2015) Elmar Wolf et al.   TRENDS IN CELL BIOLOGY

Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis

(2015) E. Chevet et al.   Cancer Discovery

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma

(2015) David Y.A. Dadey et al.   Oncotarget

Endoplasmic Reticulum Stress in Malignancy

(2014) Hanna J. Clarke et al.   CANCER CELL

Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway

(2014) Zhao V. Wang et al.   CELL

The Metastasis Suppressor, N-myc Downstream-regulated Gene 1 (NDRG1), Inhibits Stress-induced Autophagy in Cancer Cells

(2014) Sumit Sahni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer

(2014) Ayesha N Shajahan-Haq et al.   Molecular Cancer

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

(2014) Mario Sanches et al.   Nature Communications

An Overview of MYC and Its Interactome

(2014) M. Conacci-Sorrell et al.   Cold Spring Harbor Perspectives in Medicine

Physiological roles of regulated Ire1 dependent decay

(2014) Dina S. Coelho et al.   Frontiers in Genetics

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers

(2013) Anouk Emadali et al.   EMBO Molecular Medicine

Mammalian Target of Rapamycin Complex 1 (mTORC1) Enhances Bortezomib-induced Death in Tuberous Sclerosis Complex (TSC)-null Cells by a c-MYC-dependent Induction of the Unfolded Protein Response

(2013) Justin T. Babcock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

(2013) Jeffrey M. Axten et al.   ACS Medicinal Chemistry Letters

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

The Role of MIZ-1 in MYC-Dependent Tumorigenesis

(2013) K. E. Wiese et al.   Cold Spring Harbor Perspectives in Medicine

Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster

(2013) Péter Nagy et al.   PLoS Genetics

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

(2012) Guoliang Qing et al.   CANCER CELL

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

(2012) Lori S. Hart et al.   JOURNAL OF CLINICAL INVESTIGATION

The Cdc48 machine in endoplasmic reticulum associated protein degradation

(2011) Dieter H. Wolf et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland

(2011) X. Wang et al.   CANCER RESEARCH

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy

(2009) K. J. Savage et al.   BLOOD

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE

ATF6 -Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

(2008) D. M. Schewe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA