Article
Oncology
Daniel J. Landsburg, Alexa Koike, Sunita D. Nasta, Jakub Svoboda, Stephen J. Schuster, Mariusz A. Wasik, Gabriel C. Caponetti
Summary: The study revealed frequent overexpression of immune checkpoint proteins in tumor tissue from patients with MYC-overexpressing DLBCL and BCLU/HGBL, with differences in overexpression patterns based on MYC-R status. These findings provide a biological rationale for investigating the use of checkpoint inhibitor therapies in these subgroups.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Computer Science, Artificial Intelligence
Guilherme Botazzo Rozendo, Marcelo Zanchetta do Nascimento, Guilherme Freire Roberto, Paulo Rogerio de Faria, Adriano Barbosa Silva, Thaina Aparecida Azevedo Tosta, Leandro Alves Neves
Summary: Computational systems for studying and diagnosing non-Hodgkin's lymphomas have been developed to assist specialists in decision-making. However, the use of sample entropy to assess disease characteristics and distinguish different types of lymphomas has not been fully explored. In this study, a method utilizing sample entropy signatures, multiple segmentation techniques, and color normalization models was proposed to study chronic lymphocytic leukemia, follicular lymphoma, and mantle cell lymphoma. The approach showed significant advances in computer-aided diagnosis systems by providing accurate results without the need for preprocessing steps.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Review
Oncology
Mutaz Jamal Al-Khreisat, Faezahtul Arbaeyah Hussain, Ali Mahmoud Abdelfattah, Alhomidi Almotiri, Ola Mohammed Al-Sanabra, Muhammad Farid Johan
Summary: Lymphomas are malignant tumors of white blood cells, classified into Hodgkin and non-Hodgkin lymphoma. Peripheral T cell lymphomas, a rare subtype, have different cellular morphology and genetic mutations, with pathological factors playing a significant role.
Article
Pathology
Kunwar Singh, Lhara S. Lezama, Jason Kurzer, Jean Oak, Liora M. Schultz, Ann Walkush, Tse-Chang Cheng, Everett H. Chen, William A. May, Cheryl Chang, Michael P. Link, Ranjana H. Advani, Carlos J. Suarez, Yasodha Natkunam
Summary: Classic Hodgkin lymphoma (CHL) patients may have prior or recurrent diseases resembling non-Hodgkin lymphomas, which pose challenges for diagnosis. A study of CHL patients revealed shared genetic variants between CHL and other lymphomas such as PMBL, DLBCL, or MGZL, suggesting clonal relationships. Mutational profiling can provide valuable information for guiding therapeutic decisions in patients with refractory disease. These findings contribute to a better understanding of the genetic events and clinical impact of CHL and related lymphomas.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Biochemical Research Methods
Kristin L. Leskoske, Krystine Garcia-Mansfield, Ritin Sharma, Aparna Krishnan, Jessica M. Rusert, Jill P. Mesirov, Robert J. Wechsler-Reya, Patrick Pirrotte
Summary: Medulloblastoma (MB) is the most common malignant pediatric brain tumor, classified into different molecular subgroups. Mass spectrometry-based proteomics and phosphoproteomics were used to study MB, and the PDX tumors of MB were found to have similar proteomic profiles with primary human MB tumors. Additionally, several potential pathways that could serve as new therapeutic targets for MB were identified.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Hematology
Yanqing Zhang, Xin Zhang, Yi Zhang, Han Xu, Zichen Wei, Xin Wang, Yan Li, Junrong Guo, Fan Wu, Xiao Fang, Lei Pang, Bin Deng, Duonan Yu
Summary: Myc inhibits LAPTM5 expression in B-lymphoma cells by binding to its promoter and activating miR-17-3p, which leads to the downregulation of LAPTM5 protein synthesis. This interaction between Myc, LAPTM5, and miR-17-3p promotes the growth and progression of B-lymphomas.
ANNALS OF HEMATOLOGY
(2023)
Article
Hematology
Marie-Charlotte Laude, Laure Lebras, Pierre Sesques, Herve Ghesquieres, Simon Favre, Krimo Bouabdallah, Carolyne Croizier, Romain Guieze, Laurianne Drieu La Rochelle, Emmanuel Gyan, Roza Chin, Therese Aurran-Schleinitz, Amira Marouf, Benedicte Deau-Fischer, Paul Coppo, Sandrine Malot, Xavier Roussel, Adrien Chauchet, Marianne Schwarz, Charles Bescond, Thierry Lamy de la Chapelle, Lucile Bussot, Sylvain Carras, Benedicte Burlet, Cedric Rossi, Adrien Daniel, Franck Morschhauser, Fabien Subtil, Anne-Sophie Michallet
Summary: Intensive chemotherapy showed significantly longer progression free survival (PFS) for advanced stage DHL and THL, but no impact on overall survival (OS). Patients with central nervous system (CNS) involvement had significantly lower survival rates. More prospective randomized trials are needed for the treatment of DHL and THL in Europe.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Oncology
Luise Victoria Claass, Patrick Mayr, Lisa Paschold, Thomas Weber, Denis Terziev, Bertram Jehs, Richard Brill, Johannes Dober, Bruno Maerkl, Claudia Wickenhauser, Piotr Czapiewski, Martin Trepel, Rainer Claus, Mascha Binder
Summary: SARS-CoV-2 vaccines do not seem to be associated with the development of lymphomas in the lymph nodes of the deltoid region used for vaccination. The study found that cases of unilateral axillary lymphomas occurred both before and after the introduction of SARS-CoV-2 vaccines, and there was no evidence of a correlation between the vaccines and the malignant clonotypes.
Review
Medicine, Research & Experimental
Javid Sadri Nahand, Layla Shojaie, Seyed Amirreza Akhlagh, Mohammad Saeid Ebrahimi, Hamid Reza Mirzaei, Hossein Bannazadeh Baghi, Maryam Mahjoubin-Tehran, Nima Rezaei, Michael R. Hamblin, Vida Tajiknia, Neda Rahimian, Hamed Mirzaei
Summary: Viral infections can alter cell death pathways and affect the life and death of cells.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Pharmacology & Pharmacy
Zui Chen, Long Qiu Cheng
Summary: The study demonstrates that eupafolin induces apoptosis and promotes autophagy in the B-cell non-Hodgkin lymphoma cell line OCI-LY-3, through regulation of the Akt/mTOR and NF-Kappa B signaling pathways.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pinelopi I. Artemaki, Petros A. Letsos, Ioanna C. Zoupa, Katerina Katsaraki, Paraskevi Karousi, Sotirios G. Papageorgiou, Vasiliki Pappa, Andreas Scorilas, Christos K. Kontos
Summary: Normal B-cell development is a tightly regulated complex procedure, the deregulation of which can lead to lymphomagenesis. MicroRNAs (miRNAs) play a significant role in indolent B-cell NHLs by influencing gene expression regulation networks. Understanding the multifaceted role of miRNAs in B-cell lymphomas could provide insights into potential biomarkers and therapeutic targets for these malignancies.
Review
Gastroenterology & Hepatology
Michael D. Diamantidis, Maria Papaioannou, Evdoxia Hatjiharissi
Summary: Primary gastric lymphomas are distinct lymphoproliferative neoplasms with heterogeneous clinical and molecular profiles. Clinical research in this field has been lacking sufficient data to guide optimal care, with a multidisciplinary approach typically employed. Immunochemotherapy, particularly rituximab-CHOP, shows promise for achieving better outcomes in management.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Cuifen Zhang, Xiaohong Zhang, Zeyu Liu, Jiahao Tao, Lizhu Lin, Linzhu Zhai
Summary: Evidence on the need for surgery for primary intestinal non-Hodgkin lymphoma (PINHL) patients receiving chemotherapy is limited and controversial, but this study found that surgery combined with chemotherapy significantly improved overall survival and cancer-specific survival for these patients.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Victor Manuel Orellana-Noia, Daniel R. Reed, Ashley Alesia McCook, Jeremy Michael Sen, Christian M. Barlow, Mary-Kate Malecek, Marcus Watkins, Brad S. Kahl, Michael A. Spinner, Ranjana Advani, Timothy J. Voorhees, Anson Snow, Natalie Sophia Grover, Amy Ayers, Jason Romancik, Yuxin Liu, Scott F. Huntington, Julio C. Chavez, Hayder Saeed, Aleksandr Lazaryan, Vikram Raghunathan, Stephen E. Spurgeon, Thomas A. Ollila, Christopher Del Prete, Adam Olszewski, Emily C. Ayers, Daniel J. Landsburg, Benjamin Echalier, Jun Lee, Manali Kamdar, Paolo F. Caimi, Timothy Fu, Jieqi Liu, Kevin A. David, Hanan Alharthy, Jennie Law, Reem Karmali, Harsh Shah, Deborah M. Stephens, Ajay Major, Alexandra E. Rojek, Sonali M. Smith, Amulya Yellala, Avyakta Kallam, Shazi Nakhoda, Nadia Khan, Mohammad Ahsan Sohail, Brian T. Hill, Odeth Barrett-Campbell, Frederick Lansigan, Jeffrey Switchenko, Jonathon Cohen, Craig A. Portell
Summary: This study on CNS prophylaxis in DLBCL patients found no significant difference in CNS relapse rates between different routes of administration. However, relapse rates remain elevated in high-risk subgroups, highlighting the need for reevaluation of prophylaxis strategies.
Review
Pathology
Socorro Maria Rodriguez-Pinilla, Stefan Docjinov, Snjezana Dotlic, Sarah E. Gibson, Sylvia Hartmann, Monika Klimkowska, Elena Sabattini, Thomas A. Tousseyn, Daphne de Jong, Eric. D. Hsi
Summary: Session IV of the 2020 EAHP Workshop focused on the classification of aggressive B-cell non-Hodgkin lymphomas. This manuscript summarizes the features of submitted cases and highlights the challenges in differential diagnosis. Specific issues discussed include high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements, large B-cell lymphomas with IRF4 rearrangement, high-grade/large B-cell lymphomas with 11q aberration, Burkitt lymphoma, and pleomorphic mantle cell lymphoma.
