Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer

BRPF1 ‐associated intellectual disability, ptosis, and facial dysmorphism in a multiplex family

(2019) Naomi Pode‐Shakked et al.   Molecular Genetics & Genomic Medicine

Novel BRPF1 mutation in a boy with intellectual disability, coloboma, facial nerve palsy and hypoplasia of the corpus callosum

(2019) Sofie Demeulenaere et al.   European Journal of Medical Genetics

KAT6A Syndrome: genotype–phenotype correlation in 76 patients with pathogenic KAT6A variants

(2018) Joanna Kennedy et al.   GENETICS IN MEDICINE

Novel truncating variants expand the phenotypic spectrum of KAT6B -related disorders

(2018) Alejandro Brea-Fernández et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Automated Clinical Exome Reanalysis Reveals Novel Diagnoses

(2018) Samuel W. Baker et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

Histone propionylation is a mark of active chromatin

(2017) Adam F Kebede et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recognition of Histone H3K14 Acylation by MORF

(2017) Brianna J. Klein et al.   STRUCTURE

Histone propionylation is a mark of active chromatin

(2017) Adam F Kebede et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

BRPF1 is essential for development of fetal hematopoietic stem cells

(2016) Linya You et al.   JOURNAL OF CLINICAL INVESTIGATION

Diverse Activities of Histone Acylations Connect Metabolism to Chromatin Function

(2016) Arnob Dutta et al.   MOLECULAR CELL

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain

(2016) Yuanyuan Li et al.   MOLECULAR CELL

Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2

(2016) Xiaozhe Xiong et al.   Nature Chemical Biology

The Taf14 YEATS domain is a reader of histone crotonylation

(2016) Forest H Andrews et al.   Nature Chemical Biology

ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing

(2016) Xingqi Chen et al.   NATURE METHODS

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of MYST3 as a novel epigenetic activator of ERα frequently amplified in breast cancer

(2016) L Yu et al.   ONCOGENE

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

(2016) Sushabhan Sadhukhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dominant Mutations in KAT6A Cause Intellectual Disability with Recognizable Syndromic Features

(2015) Emma Tham et al.   AMERICAN JOURNAL OF HUMAN GENETICS

De Novo Nonsense Mutations in KAT6A, a Lysine Acetyl-Transferase Gene, Cause a Syndrome Including Microcephaly and Global Developmental Delay

(2015) Valerie A. Arboleda et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MOZ and MORF acetyltransferases: Molecular interaction, animal development and human disease

(2015) Xiang-Jiao Yang   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation

(2015) Y. Feng et al.   EMBO JOURNAL

The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival

(2015) Kezhi Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chromatin Regulator Brpf1 Regulates Embryo Development and Cell Proliferation

(2015) Linya You et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of the Chromatin Regulator Brpf1 Causes Abnormal Brain Development

(2015) Linya You et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

(2015) Benjamin R. Sabari et al.   MOLECULAR CELL

HDAC1,2 inhibition impairs EZH2- and BBAP- mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma

(2015) Danielle P. Johnson et al.   Oncotarget

The Lysine Acetyltransferase Activator Brpf1 Governs Dentate Gyrus Development through Neural Stem Cells and Progenitors

(2015) Linya You et al.   PLoS Genetics

An individual with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) and additional features expands the phenotype associated with mutations inKAT6B

(2014) Hung-Chun Yu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Expression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos

(2014) Linya You et al.   Epigenetics

Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factorspire

(2014) Fu Huang et al.   GENES & DEVELOPMENT

Tn5 transposase and tagmentation procedures for massively scaled sequencing projects

(2014) Simone Picelli et al.   GENOME RESEARCH

Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism

(2014) Olga Pougovkina et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

An improved predictive recognition model for Cys2-His2 zinc finger proteins

(2014) Ankit Gupta et al.   NUCLEIC ACIDS RESEARCH

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

(2014) Robert Huether et al.   Nature Communications

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity

(2013) M.-E. Lalonde et al.   GENES & DEVELOPMENT

De Novo Mutations of the Gene Encoding the Histone Acetyltransferase KAT6B Cause Genitopatellar Syndrome

(2012) Michael A. Simpson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in KAT6B, Encoding a Histone Acetyltransferase, Cause Genitopatellar Syndrome

(2012) Philippe M. Campeau et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Whole-Exome-Sequencing Identifies Mutations in Histone Acetyltransferase Gene KAT6B in Individuals with the Say-Barber-Biesecker Variant of Ohdo Syndrome

(2011) Jill Clayton-Smith et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis

(2011) Y. Mishima et al.   BLOOD

MYST protein acetyltransferase activity requires active site lysine autoacetylation

(2011) Hua Yuan et al.   EMBO JOURNAL

Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome–like phenotype and hyperactivated MAPK signaling in humans and mice

(2011) Michael Kraft et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

(2011) Hong Wu et al.   PLoS One

HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development

(2010) A. J. Kueh et al.   MOLECULAR AND CELLULAR BIOLOGY

MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair

(2010) G. G. Sharma et al.   MOLECULAR AND CELLULAR BIOLOGY

MOF and H4 K16 Acetylation Play Important Roles in DNA Damage Repair by Modulating Recruitment of DNA Damage Repair Protein Mdc1

(2010) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

(2010) Alessandro Vezzoli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mof (MYST1 or KAT8) Is Essential for Progression of Embryonic Development Past the Blastocyst Stage and Required for Normal Chromatin Architecture

(2008) T. Thomas et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes

(2008) M. Ullah et al.   MOLECULAR AND CELLULAR BIOLOGY

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY