Puerarin Alleviates Lipopolysaccharide-Induced Myocardial Fibrosis by Inhibiting PARP-1 to Prevent HMGB1-Mediated TLR4-NF-κB Signaling Pathway

Alleviation of Inflammatory Response of Pulmonary Fibrosis in Acute Respiratory Distress Syndrome by Puerarin via Transforming Growth Factor (TGF-β1)

(2019) Xiaoming Hu et al.   MEDICAL SCIENCE MONITOR

Renal Denervation Effects on Myocardial Fibrosis and Ventricular Arrhythmias in Rats with Ischemic Cardiomyopathy

(2018) Bin Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Targeting HMGB1 ameliorates cardiac fibrosis through restoring TLR2-mediated autophagy suppression in myocardial fibroblasts

(2018) Ri-Na Wu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways

(2018) Lu Meng et al.   MOLECULAR IMMUNOLOGY

Toll-like receptors and their role in persistent pain

(2018) Michael J. Lacagnina et al.   PHARMACOLOGY & THERAPEUTICS

Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio

(2018) Mingxiao Zhang et al.   Clinics and Research in Hepatology and Gastroenterology

Myocardial fibrosis: biomedical research from bench to bedside

(2017) Mariann Gyöngyösi et al.   EUROPEAN JOURNAL OF HEART FAILURE

HMGB1 induced endothelial permeability promotes myocardial fibrosis in diabetic cardiomyopathy

(2017) Zhaowei Zhu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury

(2017) Xiangrong Chen et al.   Journal of Neuroinflammation

Long Noncoding RNA Malat1 Regulates Cerebrovascular Pathologies in Ischemic Stroke

(2017) Xuejing Zhang et al.   JOURNAL OF NEUROSCIENCE

Puerarin attenuates cisplatin-induced rat nephrotoxicity: The involvement of TLR4/NF-κB signaling pathway

(2017) Xu Ma et al.   PLoS One

Puerarin attenuates renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis via MAPK signal pathways in vivo and in vitro

(2017) Xiangjun Zhou et al.   RENAL FAILURE

Myocardial fibrosis predicts ventricular tachyarrhythmias

(2017) Marcello Disertori et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-β1/Smad2-Mediated Endothelial-to-Mesenchymal Transition

(2017) Ya-Ge Jin et al.   PPAR Research

The Effects and Possible Mechanisms of Puerarin to Treat Uterine Fibrosis Induced by Ischemia-Reperfusion Injury in Rats

(2017) Lin Lin et al.   MEDICAL SCIENCE MONITOR

Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly(ADP-ribose) polymerase 1 (PARP-1)

(2016) Riham Soliman Said et al.   BIOCHEMICAL PHARMACOLOGY

The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival

(2016) T. Jubin et al.   CELL PROLIFERATION

The Biological Basis for Cardiac Repair After Myocardial Infarction

(2016) Sumanth D. Prabhu et al.   CIRCULATION RESEARCH

Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition

(2016) Shuai Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy

(2016) Ying-Qing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction

(2016) Samantha D. Francis Stuart et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs)

(2016) Neil A. Turner   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

HMGB1 induced inflammatory effect is blocked by CRISPLD2 via MiR155 in hepatic fibrogenesis

(2016) Haoye Zhang et al.   MOLECULAR IMMUNOLOGY

HMGB1 as biomarker and drug target

(2016) Emilie Venereau et al.   PHARMACOLOGICAL RESEARCH

Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways

(2016) Xi Li et al.   TOXICOLOGY LETTERS

Inhibition of Uncoupling Protein 2 Attenuates Cardiac Hypertrophy Induced by Transverse Aortic Constriction in Mice

(2015) Xiao-Bing Ji et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Critical role of RAGE and HMGB1 in inflammatory heart disease

(2015) Anna Bangert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1β signaling

(2015) M Zhang et al.   Cell Death & Disease

PARP-1 Mediates LPS-Induced HMGB1 Release by Macrophages through Regulation of HMGB1 Acetylation

(2014) Zhiyong Yang et al.   JOURNAL OF IMMUNOLOGY

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Anti-inflammatory effects of rutin on HMGB1-induced inflammatory responses in vitro and in vivo

(2013) Hayoung Yoo et al.   INFLAMMATION RESEARCH

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Puerarin: A Review of Pharmacological Effects

(2013) Yan-Xi Zhou et al.   PHYTOTHERAPY RESEARCH

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

(2012) M.-F. Langelier et al.   SCIENCE