Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-β1/Smad2-Mediated Endothelial-to-Mesenchymal Transition

Puerarin inhibits M2 polarization and metastasis of tumor-associated macrophages from NSCLC xenograft model via inactivating MEK/ERK 1/2 pathway

(2017) Honggang Kang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Root Extract of Pueraria lobata and Its Main Compound, Puerarin, Prevent Obesity by Increasing the Energy Metabolism in Skeletal Muscle

(2017) Hyo Jung et al.   Nutrients

Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion InjuryNovelty and Significance

(2016) Meryl C. Woodall et al.   CIRCULATION RESEARCH

Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition

(2016) Shuai Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Losartan Attenuates Myocardial Endothelial-To-Mesenchymal Transition in Spontaneous Hypertensive Rats via Inhibiting TGF-β/Smad Signaling

(2016) Miao Wu et al.   PLoS One

Pioglitazone Protected against Cardiac Hypertrophy via Inhibiting AKT/GSK3βand MAPK Signaling Pathways

(2016) Wen-Ying Wei et al.   PPAR Research

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

Blocking protein phosphatase 2A signaling prevents endothelial-to-mesenchymal transition and renal fibrosis: a peptide-based drug therapy

(2016) Yuanjun Deng et al.   Scientific Reports

Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats

(2016) Wenping Li et al.   Journal of Diabetes Research

Puerarin Attenuates Cardiac Hypertrophy Partly Through Increasing Mir-15b/195 Expression and Suppressing Non-Canonical Transforming Growth Factor Beta (Tgfβ) Signal Pathway

(2016) Xiuzhou Zhang et al.   MEDICAL SCIENCE MONITOR

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2015) Robert B. Good et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial-mesenchymal transition is regulated at post-transcriptional levels by transforming growth factor-β signaling during tumor progression

(2015) Masao Saitoh   CANCER SCIENCE

Puerarin attenuates the inflammatory response and apoptosis in LPS-stimulated cardiomyocytes

(2015) YUAN YUAN et al.   Experimental and Therapeutic Medicine

Effects of Puerarin on Lipid Accumulation and Metabolism in High-Fat Diet-Fed Mice

(2015) Guodong Zheng et al.   PLoS One

Chemotherapeutic Drugs Induce PPAR-γ Expression and Show Sequence-Specific Synergy with PPAR-γ Ligands in Inhibition of Non–Small Cell Lung Cancer

(2015) Raju C. Reddy et al.   NEOPLASIA

Curcumin attenuates cardiac fibrosis in spontaneously hypertensive rats through PPAR-γ activation

(2014) Zhe Meng et al.   ACTA PHARMACOLOGICA SINICA

PPAR- /IL-10 Axis Inhibits MyD88 Expression and Ameliorates Murine Polymicrobial Sepsis

(2014) A. E. Ferreira et al.   JOURNAL OF IMMUNOLOGY

Puerarin Attenuated Early Diabetic Kidney Injury through Down-Regulation of Matrix Metalloproteinase 9 in Streptozotocin-Induced Diabetic Rats

(2014) Yifei Zhong et al.   PLoS One

Effects of rosiglitazone (PPAR γagonist) on the myocardium in non-hypertensive diabetic rats 罗格列酮（PPARγ激动剂）对非高血压糖尿病大鼠的心肌的影响

(2014) Khodor Abou Daya et al.   Journal of Diabetes

Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway

(2013) Chao Guo et al.   FOOD AND CHEMICAL TOXICOLOGY

Puerarin attenuates pressure overload-induced cardiac hypertrophy

(2013) Yuan Yuan et al.   Journal of Cardiology

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of the Inflammatory Response in Cardiac Repair

(2012) Nikolaos G. Frangogiannis   CIRCULATION RESEARCH

Myofibroblasts

(2012) Biao Hu et al.   CURRENT OPINION IN RHEUMATOLOGY

Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages

(2012) Xiu-Juan Yao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as a biomarker?

(2012) Katja Lakota et al.   ARTHRITIS RESEARCH & THERAPY

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases

(2011) Ka H. Wong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Endothelial Cell–Derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Hearts Through Stimulation of Endothelial-to-Mesenchymal Transition

(2010) Bambang Widyantoro et al.   CIRCULATION

Transforming growth factor (TGF)-β signaling in cardiac remodeling

(2010) Marcin Dobaczewski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Peroxisome Proliferator-Activated Receptor-  Activation Inhibits Tumor Metastasis by Antagonizing Smad3-Mediated Epithelial-Mesenchymal Transition

(2010) A. K. Reka et al.   MOLECULAR CANCER THERAPEUTICS

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

(2010) Jun Wei et al.   PLoS One

PPARγ as a potential therapeutic target in pulmonary hypertension

(2010) Roy L. Sutliff et al.   Therapeutic Advances in Respiratory Disease

Rosiglitazone Attenuates Chronic Hypoxia–Induced Pulmonary Hypertension in a Mouse Model

(2009) Rachel E. Nisbet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Peroxisome proliferator-activated receptor-γ abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

(2009) Asish K. Ghosh et al.   FASEB JOURNAL

The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis

(2009) Robert M. Strieter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Ciglitazone ameliorates lung inflammation by modulating the inhibitor κB protein kinase/nuclear factor-κB pathway after hemorrhagic shock

(2008) Ranjit S. Chima et al.   CRITICAL CARE MEDICINE

RhoA and microtubule dynamics control cell–basement membrane interaction in EMT during gastrulation

(2008) Yukiko Nakaya et al.   NATURE CELL BIOLOGY

Synergistic Effects of PPARγLigands and Retinoids in Cancer Treatment

(2008) Masahito Shimizu et al.   PPAR Research