Article
Medicine, General & Internal
Natalia Mena-Vazquez, Rocio Redondo-Rodriguez, Marta Rojas-Gimenez, Carmen Maria Romero-Barco, Sara Manrique-Arija, Rafaela Ortega-Castro, Ana Hidalgo Conde, Rocio Arnedo Diez de los Rios, Eva Cabrera Cesar, Francisco Espildora, Maria Carmen Aguilar-Hurtado, Isabel Anon-Onate, Lorena Perez-Albaladejo, Manuel Abarca-Costalago, Inmaculada Urena-Garnica, Maria Luisa Velloso-Feijoo, Maria Victoria Irigoyen-Oyarzabal, Antonio Fernandez-Nebro
Summary: The study showed that in patients with connective tissue disease associated interstitial lung disease treated with rituximab, over half of the patients showed improvement or stabilization of the disease at the end of follow-up. Early treatment and combination with mycophenolate could reduce the risk of ILD progression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Michaela R. Anderson, John S. Kim, Matthew Allison, Jon T. Giles, Eric A. Hoffman, Jingzhong Ding, R. Graham Barr, Anna Podolanczuk
Summary: The study revealed that increased pericardial and abdominal visceral adipose tissue is associated with early lung injury on CT scans and a decrease in FVC, suggesting that adipose tissue may be a modifiable risk factor for ILD.
Article
Surgery
Amelie Riviere, Clement Picard, Cristina Berastegui, Victor Manuel Mora, Vincent Bunel, Laurent Godinas, Elena Salvaterra, Valeria Rossetti, Laurent Savale, Dominique Israel-Biet, Xavier Demant, Julien Bermudez, Federica Meloni, Peter Jaksch, Jesper Magnusson, Laurence Beaumont, Michael Perch, Jean-Francois Mornex, Christiane Knoop, John-David Aubert, Baptiste Hervier, Hilario Nunes, Marc Humbert, Jens Gottlieb, Yurdagul Uzunhan, Jerome Le Pavec
Summary: This study aimed to evaluate the survival rate and prognostic factors in lung transplant recipients with interstitial lung disease complicating idiopathic inflammatory myopathy (IIM-ILD). The study found that the post-transplant survival rate in IIM-ILD was similar to that in international all-cause transplantation registries and worse in patients with classical IIM. Muscle involvement was identified as the main factor associated with worse survival.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Chao-Hsuan Wei, Chia-Hsiang Li, Te-Chun Shen, Yu-Tung Hung, Chih-Yen Tu, Te-Chun Hsia, Wu-Huei Hsu, Chung Y. Hsu
Summary: This nationwide retrospective cohort study found a significant association between pneumoconiosis and an increased risk of chronic kidney disease (CKD). The risk was even higher among patients with pneumoconiosis who also had hypertension, hyperglycemia, or hyperlipidemia.
Article
Medicine, Research & Experimental
Natalia Mena-Vazquez, Marta Rojas-Gimenez, Carmen Maria Romero-Barco, Myriam Gandia-Martinez, Nair Perez-Gomez, Francisco Javier Godoy-Navarrete, Sara Manrique-Arija, Aimara Garcia-Studer, Jerusalem Calvo-Gutierrez, Clara Fuego Varela, Pilar Morales-Garrido, Patricia Castro Perez, Coral Mourino-Rodriguez, Isabel Anon-Onate, Francisco Espildora, Maria Carmen Aguilar-Hurtado, Rocio Redondo, Ana Hidalgo Conde, Rocio Arnedo Diez de los Rios, Eva Cabrera Cesar, Maria Luisa Velloso-Feijoo, Antonio Fernandez-Nebro
Summary: The study aimed to describe comorbid conditions in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and analyze factors associated with multimorbidity. The results showed that comorbid conditions were more frequent in RA-ILD patients compared to those with RA but not ILD. Age, inflammatory markers, and lung function were found to be associated with multimorbidity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Rheumatology
Ahmad Ramahi, Alain Lescoat, David Roofeh, Vivek Nagaraja, Rajaie Namas, Suiyuan Huang, John Varga, David O'Dwyer, Bonnie Wang, Kevin Flaherty, Ella Kazerooni, Dinesh Khanna
Summary: The aim of this study was to identify risk factors of percent predicted forced vital capacity (ppFVC) decline in patients with SSc-associated interstitial lung disease (SSc-ILD). The study analyzed the pulmonary function test results of 312 SSc-ILD patients and found that longer disease duration, ILD extent >20%, and anti-topoisomerase I (ATA) positivity were significantly associated with ppFVC decline. Among these factors, ATA positivity showed the strongest correlation with ppFVC decline.
Article
Cardiac & Cardiovascular Systems
Raphael Le Mao, Thomas Ropars, Cecile Tromeur, Aude Barnier, Baptiste Hourmant, Marie Guegan, David Jimenez, Christophe Leroyer, Karine Lacut, Francis Couturaud
Summary: The study suggests that the risk of recurrent VTE after stopping anticoagulation and the risk of bleeding under anticoagulation are very high in patients with ILD. Therefore, it is recommended that anticoagulation should not be prolonged beyond 3-6 months in most cases.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Biochemistry & Molecular Biology
Ju-Hsin Chang, Te-Chun Shen, Ke-Wei Chen, Cheng-Li Lin, Chung Y. Hsu, Yeong-Ray Wen, Kuan-Cheng Chang
Summary: This retrospective cohort study aimed to elucidate the relationship between pneumoconiosis (PCN) and acute myocardial infarction (AMI). The results showed that patients with PCN had a significantly higher risk of developing AMI. Therefore, clinicians should pay more attention to prevent AMI episodes in patients with PCN.
Article
Oncology
Kenji Sawa, Izumi Sato, Masato Takeuchi, Koji Kawakami
Summary: The risk of developing pneumonitis with ICIs for NSCLC patients with preexisting ILD was similar to that with conventional chemotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Critical Care Medicine
Kerri I. Aronson, Adam M. Martin-Schwarze, Jeffrey J. Swigris, Giselle Kolenic, Jamuna K. Krishnan, Anna J. Podolanczuk, Robert J. Kaner, Fernando J. Martinez, Monika M. Safford, Laura C. Pinheiro
Summary: This study aimed to evaluate the validity and reliability of the Fatigue Severity Scale (FSS) in assessing fatigue in patients with interstitial lung disease (ILD). The study found that fatigue is a common and debilitating symptom in ILD patients, which is poorly correlated with physiological measures of disease severity. Therefore, there is a need for a reliable and valid patient-reported measure of fatigue in ILD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Rheumatology
Gregory C. Mcdermott, Keigo Hayashi, Kazuki Yoshida, Matthew Moll, Michael H. Cho, Tracy J. Doyle, Gregory L. Kinney, Paul F. Dellaripa, Rachel K. Putman, Raul San Jose Estepar, Akinori Hata, Takuya Hino, Tomoyuki Hida, Masahiro Yanagawa, Mizuki Nishino, George Washko, Elizabeth A. Regan, Hiroto Hatabu, Gary M. Hunninghake, Edwin K. Silverman, Jeffrey A. Sparks
Summary: This study found an association between rheumatoid arthritis (RA) and interstitial lung abnormalities (ILAs), which persisted even after adjusting for smoking and genetic/lifestyle risk factors. RA patients with ILAs who were smokers had a three-fold increased risk of all-cause mortality, emphasizing the importance of early screening and treatment strategies for ILD in RA.
Article
Critical Care Medicine
Yet H. Khor, Lawrence Gutman, Nebal Abu Hussein, Kerri A. Johannson, Ian N. Glaspole, Sabina A. Guler, Manuela Funke-Chambour, Thomas Geiser, Nicole S. L. Goh, Christopher J. Ryerson
Summary: Patients with idiopathic pulmonary fibrosis (IPF) have higher cumulative incidence of exertional and resting hypoxemia compared with patients without IPF. The extended ILD-GAP-O-2 model provides additional risk stratification for 1-year prognosis in patients with fibrotic ILD.
Article
Respiratory System
Mohammed A. Malik Farooqi, Sachi O'Hoski, Sarah Goodwin, Nima Makhdami, Afia Aziz, Gerard Cox, Joshua Wald, Christopher J. Ryerson, Marla K. Beauchamp, Nathan Hambly, Martin Kolb
Summary: This study described the prevalence of physical frailty and its association with mortality in patients with fibrotic ILD. The results showed that both pre-frail and frail individuals had a higher risk of death compared to non-frail individuals, and assessment of physical frailty may provide additional prognostic value beyond existing risk scores like the ILD-GAP score.
Article
Medicine, General & Internal
Natalia Mena-Vazquez, Marta Rojas-Gimenez, Carmen Maria Romero-Barco, Sara Manrique-Arija, Ana Hidalgo Conde, Rocio Arnedo Diez de los Rios, Eva Cabrera Cesar, Rafaela Ortega-Castro, Francisco Espildora, Maria Carmen Aguilar-Hurtado, Isabel Anon-Onate, Lorena Perez-Albaladejo, Manuel Abarca-Costalago, Inmaculada Urena-Garnica, Maria Luisa Velloso-Feijoo, Rocio Redondo-Rodriguez, Antonio Fernandez-Nebro
Summary: The study found that about half of patients with interstitial lung disease associated with systemic autoimmune disease stabilize or improve after a median of 5 years, but over one-third of patients die. Rheumatoid arthritis is associated with higher rates of disease progression and hospitalization in ILD, while usual interstitial pneumonia pattern, FVC%, and smoking are independent predictors for worsening of ILD-SAI.
Article
Rheumatology
Qiang Li, Laura Wallace, Padmaja Patnaik, Margarida Alves, Martina Gahlemann, Veronika Kohlbrenner, Christina Raabe, Jocelyn R. Wang, Elizabeth M. Garry
Summary: The study found low prevalence estimates and incidence rates for SSc and SSc-ILD in the US, with newly diagnosed SSc-ILD patients receiving more immunosuppressive therapy and having more comorbidities compared to newly diagnosed SSc patients.