Targeting desmosomal adhesion and signalling for intestinal barrier stabilization in inflammatory bowel diseases—Lessons from experimental models and patients

Dendritic Cell Subsets in Intestinal Immunity and Inflammation

(2020) Tian Sun et al.   JOURNAL OF IMMUNOLOGY

An engineering probiotic producing defensin-5 ameliorating dextran sodium sulfate-induced mice colitis via Inhibiting NF-kB pathway

(2020) Lishan Zeng et al.   Journal of Translational Medicine

Enteroids Generated from Patients with Severe Inflammation in Crohn’s Disease Maintain Alterations of Junctional Proteins

(2020) Michael Meir et al.   Journal of Crohns & Colitis

Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration

(2020) Sven Flemming et al.   MOLECULAR BIOLOGY OF THE CELL

Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation

(2019) Shuling Fan et al.   MOLECULAR BIOLOGY OF THE CELL

E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease

(2019) Amanda C. Daulagala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease

(2019) Michael Meir et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate immune cell–epithelial crosstalk during wound repair

(2019) Jennifer C. Brazil et al.   JOURNAL OF CLINICAL INVESTIGATION

The multiple faces of inflammatory enteric glial cells: is Crohn’s disease a gliopathy?

(2018) Camille Pochard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Rho Kinase Inhibition Maintains Intestinal and Vascular Barrier Function by Upregulation of Occludin in Experimental Necrotizing Enterocolitis

(2018) Justyna S Grothaus et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion

(2018) Hanna Ungewiß et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines

(2018) Mark Yulis et al.   Cell Death & Disease

Pemphigus—A Disease of Desmosome Dysfunction Caused by Multiple Mechanisms

(2018) Volker Spindler et al.   Frontiers in Immunology

Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury

(2018) Annika Gross et al.   Mucosal Immunology

Interplay between tight junctions & adherens junctions

(2017) Hannah K. Campbell et al.   EXPERIMENTAL CELL RESEARCH

Optimization of biologic therapy in Crohn’s disease

(2017) Mohammed Razvi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling

(2017) Miguel Quiros et al.   JOURNAL OF CLINICAL INVESTIGATION

The Gastrointestinal Microbiome: A Review

(2017) P.C. Barko et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

The Interplay between Defensins and Microbiota in Crohn’s Disease

(2017) Lorena Coretti et al.   MEDIATORS OF INFLAMMATION

Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis

(2017) S M Krug et al.   Mucosal Immunology

Inflammatory Bowel Disease-Unclassified in Children: Diagnosis and Pharmacological Management

(2017) Giulia D’Arcangelo et al.   PEDIATRIC DRUGS

Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase

(2017) Hanna Ungewiß et al.   Scientific Reports

The glial cell-line derived neurotrophic factor: a novel regulator of intestinal barrier function in health and disease

(2016) Michael Meir et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair

(2016) Anny-Claude Luissint et al.   GASTROENTEROLOGY

TGF-β Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota

(2016) Sozaburo Ihara et al.   JOURNAL OF IMMUNOLOGY

Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing

(2016) Vera Rötzer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway

(2016) Zhigang Wei et al.   Oncotarget

Human Intestinal Barrier Function in Health and Disease

(2016) Julia König et al.   Clinical and Translational Gastroenterology

Glial cell line-derived neurotrophic factor promotes barrier maturation and wound healing in intestinal epithelial cells in vitro

(2015) Michael Meir et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Genetics of Inflammatory Bowel Diseases

(2015) Dermot P.B. McGovern et al.   GASTROENTEROLOGY

Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease

(2015) Ryuichi Okamoto et al.   JOURNAL OF GASTROENTEROLOGY

Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut

(2015) Andrea Michielan et al.   MEDIATORS OF INFLAMMATION

Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier

(2015) Ryuta Kamekura et al.   MOLECULAR BIOLOGY OF THE CELL

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

Epidemiology and risk factors for IBD

(2015) Ashwin N. Ananthakrishnan   Nature Reviews Gastroenterology & Hepatology

Cancers Complicating Inflammatory Bowel Disease

(2015) Laurent Beaugerie et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of HSP70 Heat Shock Proteins in the Pathogenesis and Treatment of Inflammatory Bowel Diseases

(2015) Paweł Samborski et al.   Advances in Clinical and Experimental Medicine

How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology

(2015) Simona Frosali et al.   Journal of Immunology Research

WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer

(2015) Annalucia Serafino et al.   Oncotarget

Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function

(2014) Angela Schlipp et al.   CARDIOVASCULAR RESEARCH

What Have We Learnt about the Role of the Environment and Natural Course of IBD in the New Millennium? 20-Year Follow-Up of the IBSEN Cohort

(2014) Bjørn Moum et al.   DIGESTIVE DISEASES

IBD Candidate Genes and Intestinal Barrier Regulation

(2014) Declan F. McCole   INFLAMMATORY BOWEL DISEASES

Galectin-3 Regulates Desmoglein-2 and Intestinal Epithelial Intercellular Adhesion

(2014) Kun Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Desmoglein 2 Compensates for Desmoglein 3 but Does Not Control Cell Adhesion via Regulation of p38 Mitogen-activated Protein Kinase in Keratinocytes

(2014) Eva Hartlieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The intestinal epithelium is an integral component of a communications network

(2014) Martin F. Kagnoff   JOURNAL OF CLINICAL INVESTIGATION

Pemphigus Vulgaris IgG Directly Inhibit Desmoglein 3-Mediated Transinteraction

(2014) W.-M. Heupel et al.   JOURNAL OF IMMUNOLOGY

Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling

(2014) Masatoshi Takeichi   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Surface area of the digestive tract – revisited

(2014) Herbert F Helander et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Tight junction, selective permeability, and related diseases

(2014) Susanne M. Krug et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The role of molecular remodeling in differential regulation of tight junction permeability

(2014) Jerrold R. Turner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Natural history and long-term clinical course of Crohn’s disease

(2014) Hugh James Freeman   WORLD JOURNAL OF GASTROENTEROLOGY

Innate and adaptive immunity in inflammatory bowel disease

(2013) Alessandra Geremia et al.   AUTOIMMUNITY REVIEWS

Definition and evaluation of mucosal healing in clinical practice

(2013) Silvia Mazzuoli et al.   DIGESTIVE AND LIVER DISEASE

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

(2013) Holm H Uhlig   GUT

Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux

(2013) Mary M. Buschmann et al.   MOLECULAR BIOLOGY OF THE CELL

New targets for mucosal healing and therapy in inflammatory bowel diseases

(2013) M F Neurath   Mucosal Immunology

Desmoglein 2 Is Less Important than Desmoglein 3 for Keratinocyte Cohesion

(2013) Eva Hartlieb et al.   PLoS One

The regulation and functional impact of actin assembly at cadherin cell–cell adhesions

(2013) Magdalene Michael et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells

(2012) Susanne M. Krug et al.   BIOMATERIALS

E-cadherin is required for intestinal morphogenesis in the mouse

(2012) Benjamin J. Bondow et al.   DEVELOPMENTAL BIOLOGY

Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells From Patients With Crohn's Disease

(2012) Élodie Thachil et al.   GASTROENTEROLOGY

Mucosal healing in inflammatory bowel diseases: a systematic review

(2012) Markus F Neurath et al.   GUT

Innate immune dysfunction in inflammatory bowel disease

(2012) M. Gersemann et al.   JOURNAL OF INTERNAL MEDICINE

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Reduced Surface Expression of Epithelial E-Cadherin Evoked by Interferon-Gamma Is Fyn Kinase-Dependent

(2012) David Smyth et al.   PLoS One

The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1

(2012) Annica Vlad-Fiegen et al.   FEBS Open Bio

An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants

(2011) Jenny K. Gustafsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Distribution of enteric glia and GDNF during gut inflammation

(2011) Georg BT von Boyen et al.   BMC GASTROENTEROLOGY

Classification and functions of enteroendocrine cells of the lower gastrointestinal tract

(2011) Ashok R. Gunawardene et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling

(2011) Keli Kolegraff et al.   MOLECULAR BIOLOGY OF THE CELL

Inflammatory Skin and Bowel Disease Linked toADAM17Deletion

(2011) Diana C. Blaydon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing

(2011) Catia Sternini et al.   Current Opinion in Endocrinology Diabetes and Obesity

Actin reorganization contributes to loss of cell adhesion in pemphigus vulgaris

(2010) Martin Gliem et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Desmoglein 2-mediated adhesion is required for intestinal epithelial barrier integrity

(2010) Nicolas Schlegel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Differential role of Rho GTPases in intestinal epithelial barrier regulation in vitro

(2010) Nicolas Schlegel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

A Key Role for E-cadherin in Intestinal Homeostasis and Paneth Cell Maturation

(2010) Marlon R. Schneider et al.   PLoS One

The Role of JAM-A in Inflammatory Bowel Disease: Unrevealing the Ties That Bind

(2009) Stefania Vetrano et al.   Annals of the New York Academy of Sciences

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

TNFα up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling

(2009) J. Mankertz et al.   CELL AND TISSUE RESEARCH

Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus

(2009) Wolfgang-Moritz Heupel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Desmocollin 3-mediated Binding Is Crucial for Keratinocyte Cohesion and Is Impaired in Pemphigus

(2009) Volker Spindler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tricellulin Forms a Barrier to Macromolecules in Tricellular Tight Junctions without Affecting Ion Permeability

(2009) Susanne M. Krug et al.   MOLECULAR BIOLOGY OF THE CELL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Clinical implications of mucosal healing for the management of IBD

(2009) Guillaume Pineton de Chambrun et al.   Nature Reviews Gastroenterology & Hepatology

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

EGFR and ADAMs Cooperate to Regulate Shedding and Endocytic Trafficking of the Desmosomal Cadherin Desmoglein 2

(2008) Jodi L. Klessner et al.   MOLECULAR BIOLOGY OF THE CELL

Repression of the Desmocollin 2 Gene Expression in Human Colon Cancer Cells Is Relieved by the Homeodomain Transcription Factors Cdx1 and Cdx2

(2008) S. Funakoshi et al.   MOLECULAR CANCER RESEARCH