E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β‐catenin modulator Annexin A1

(2019) Mara Roxana Rubinstein et al.   EMBO REPORTS

Getting a grip on adhesion: Cadherin switching and collagen signaling

(2019) Huocong Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

(2018) Rona Yaeger et al.   CANCER CELL

Mechanotransduction in tumor progression: The dark side of the force

(2018) Florence Broders-Bondon et al.   JOURNAL OF CELL BIOLOGY

Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease

(2018) Sozaburo Ihara et al.   Journal of Crohns & Colitis

C1orf106is a colitis risk gene that regulates stability of epithelial adherens junctions

(2018) Vishnu Mohanan et al.   SCIENCE

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

(2018) Christoph A. Thaiss et al.   SCIENCE

Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

(2018) Shaoyang Zhao et al.   Nature Communications

The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

(2018) Jens-Christian Röper et al.   eLife

The Role of the Gut Microbiome in Colorectal Cancer

(2018) Grace Chen   Clinics in Colon and Rectal Surgery

Cell polarity and adherens junction formation inhibit epithelial Fas cell death receptor signaling

(2018) Laurent Gagnoux-Palacios et al.   JOURNAL OF CELL BIOLOGY

Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity

(2018) Younggeon Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

E-Cadherin in Colorectal Cancer: Relation to Chemosensitivity

(2018) Irina Druzhkova et al.   Clinical Colorectal Cancer

Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis

(2018) Ishfaq Ahmed et al.   PLoS One

Colorectal Cancer Mortality Rates in Adults Aged 20 to 54 Years in the United States, 1970-2014

(2017) Rebecca L. Siegel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling

(2017) Antonis Kourtidis et al.   JOURNAL OF CELL BIOLOGY

The mucosal barrier at a glance

(2017) Marion M. France et al.   JOURNAL OF CELL SCIENCE

p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia

(2017) Sarah P. Short et al.   JOURNAL OF CLINICAL INVESTIGATION

Saccharomyces boulardii CNCM I-745 Restores intestinal Barrier Integrity by Regulation of E-cadherin Recycling

(2017) Chloé Terciolo et al.   Journal of Crohns & Colitis

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells

(2017) Qiangqiang Zhu et al.   Oncology Letters

E-cadherin: A potential biomarker of colorectal cancer prognosis

(2017) Niki Christou et al.   Oncology Letters

PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications

(2016) Antonis Kourtidis et al.   CELL CYCLE

Blood-based biomarkers for diagnosis, prognosis and treatment of colorectal cancer

(2016) Ebru E. Yörüker et al.   CLINICA CHIMICA ACTA

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

(2016) Joep Beumer et al.   DEVELOPMENT

Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma

(2016) Yuan-Chiang Chung et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Pathobiology of neutrophil-epithelial interactions

(2016) Jennifer C. Brazil et al.   IMMUNOLOGICAL REVIEWS

Extracellular Matrix and Colorectal Cancer: How Surrounding Microenvironment Affects Cancer Cell Behavior?

(2016) Sara Crotti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal–epithelial reversion induced by γ-secretase inhibition

(2016) Simona Dinicola et al.   LIFE SCIENCES

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

(2016) Henner F. Farin et al.   NATURE

The Characteristics and Prognostic Effect of E-Cadherin Expression in Colorectal Signet Ring Cell Carcinoma

(2016) Renjie Wang et al.   PLoS One

Campylobacter jejuniouter membrane vesicle-associated proteolytic activity promotes bacterial invasion by mediating cleavage of intestinal epithelial cell E-cadherin and occludin

(2015) Abdi Elmi et al.   CELLULAR MICROBIOLOGY

E-cadherin can limit the transforming properties of activating  -catenin mutations

(2015) D. J. Huels et al.   EMBO JOURNAL

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

(2015) María Elena Fernández-Sánchez et al.   NATURE

Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity

(2015) Antonis Kourtidis et al.   NATURE CELL BIOLOGY

Vitamin D and Inflammatory Bowel Disease

(2015) Marco Ardesia et al.   Biomed Research International

Cyclic stretch disrupts apical junctional complexes in Caco-2 cell monolayers by a JNK-2-, c-Src-, and MLCK-dependent mechanism

(2014) Geetha Samak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Rab11 regulates E-cadherin expression and induces cell transformation in colorectal carcinoma

(2014) Yuan-Chiang Chung et al.   BMC CANCER

Intestinal permeability – a new target for disease prevention and therapy

(2014) Stephan C Bischoff et al.   BMC GASTROENTEROLOGY

Substrate Stiffness Mediated Metastasis Like Phenotype of Colon Cancer Cells is Independent of Cell to Gel Adhesion

(2014) M. Yakut Ali et al.   Cellular and Molecular Bioengineering

c-Src drives intestinal regeneration and transformation

(2014) J. B. Cordero et al.   EMBO JOURNAL

Proteogenomic characterization of human colon and rectal cancer

(2014) Bing Zhang et al.   NATURE

Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling

(2014) Masatoshi Takeichi   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrated miRNA and mRNA Expression Profiling in Inflamed Colon of Patients with Ulcerative Colitis

(2014) Jan Van der Goten et al.   PLoS One

Microbiota organization is a distinct feature of proximal colorectal cancers

(2014) Christine M. Dejea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis

(2014) Eun Ran Kim   WORLD JOURNAL OF GASTROENTEROLOGY

The APC Network Regulates the Removal of Mutated Cells from Colonic Crypts

(2014) Je-Hoon Song et al.   Cell Reports

Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors

(2013) Kirsten Ludwig et al.   BMC CANCER

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

(2013) Mara Roxana Rubinstein et al.   Cell Host & Microbe

Numb modulates the paracellular permeability of intestinal epithelial cells through regulating apical junctional complex assembly and myosin light chain phosphorylation

(2013) Yongtao Yang et al.   EXPERIMENTAL CELL RESEARCH

Isolation and Characterization of Intestinal Stem Cells Based on Surface Marker Combinations and Colony-Formation Assay

(2013) Fengchao Wang et al.   GASTROENTEROLOGY

Chloride Channel ClC-2 is a Key Factor in the Development of DSS-induced Murine Colitis

(2013) Prashant Nighot et al.   INFLAMMATORY BOWEL DISEASES

Role of Janus Kinase 3 in Mucosal Differentiation and Predisposition to Colitis

(2013) Jayshree Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E-cadherin-integrin crosstalk in cancer invasion and metastasis

(2013) M. Canel et al.   JOURNAL OF CELL SCIENCE

Downregulated E-Cadherin Expression Indicates Worse Prognosis in Asian Patients with Colorectal Cancer: Evidence from Meta-Analysis

(2013) Xin He et al.   PLoS One

Colon Cryptogenesis: Asymmetric Budding

(2013) Chin Wee Tan et al.   PLoS One

Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis

(2013) L. E. Glover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin light chain kinase: pulling the strings of epithelial tight junction function

(2012) Kevin E. Cunningham et al.   Annals of the New York Academy of Sciences

E-cadherin is required for intestinal morphogenesis in the mouse

(2012) Benjamin J. Bondow et al.   DEVELOPMENTAL BIOLOGY

Associations Between Vitamin D Receptor Polymorphisms and Susceptibility to Ulcerative Colitis and Crohnʼs Disease

(2012) Le-Ning Xue et al.   INFLAMMATORY BOWEL DISEASES

Analysis of cell adhesion during early stages of colon cancer based on an extended multi-valued logic approach

(2012) Daniel V. Guebel et al.   Molecular BioSystems

Competitive Regulation of E-Cadherin JuxtaMembrane Domain Degradation by p120-Catenin Binding and Hakai-Mediated Ubiquitination

(2012) Andrea Hartsock et al.   PLoS One

P-Cadherin Promotes Liver Metastasis and Is Associated with Poor Prognosis in Colon Cancer

(2011) Lichao Sun et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential Targeting of the E-Cadherin/β-Catenin Complex by Gram-Positive Probiotic Lactobacilli Improves Epithelial Barrier Function

(2011) Stephanie Hummel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling

(2011) Guiomar Solanas et al.   NATURE CELL BIOLOGY

Loss of E-cadherin independently predicts the lymph node status in colorectal cancer

(2011) E. Karamitopoulou et al.   PATHOLOGY

Investigation of β-catenin and E-cadherin Expression in Dukes B2 Stage Colorectal Cancer with Tissue Microarray Method. Is It a Marker of Metastatic Potential in Rectal Cancer?

(2011) László Tóth et al.   PATHOLOGY & ONCOLOGY RESEARCH

Mechanical Force Affects Expression of an In Vitro Metastasis-Like Phenotype in HCT-8 Cells

(2010) Xin Tang et al.   BIOPHYSICAL JOURNAL

Dynamic and Static Interactions between p120 Catenin and E-Cadherin Regulate the Stability of Cell-Cell Adhesion

(2010) Noboru Ishiyama et al.   CELL

Review of biomarkers in colorectal cancer

(2010) K. F. Newton et al.   Colorectal Disease

Hypoglycosylated E-cadherin promotes the assembly of tight junctions through the recruitment of PP2A to adherens junctions

(2010) Mihai Nita-Lazar et al.   EXPERIMENTAL CELL RESEARCH

Soluble E-cadherin as a serum biomarker candidate: Elevated levels in patients with late-stage colorectal carcinoma and FAP

(2010) Jakob V. Weiß et al.   INTERNATIONAL JOURNAL OF CANCER

p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice

(2010) Whitney G. Smalley-Freed et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

Adherens junctions: from molecules to morphogenesis

(2010) Tony J. C. Harris et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology

(2010) Hisakazu OGITA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease

(2009) A. M. Muise et al.   GUT

An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth

(2009) Michael R. Dohn et al.   JOURNAL OF CELL BIOLOGY

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Structure and Biochemistry of Cadherins and Catenins

(2009) L. Shapiro et al.   Cold Spring Harbor Perspectives in Biology

Regulation of cell–cell adhesion by the cadherin–catenin complex

(2008) W. James Nelson   BIOCHEMICAL SOCIETY TRANSACTIONS

Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo

(2008) A. Milicic et al.   CANCER RESEARCH

Anchorage of Microtubule Minus Ends to Adherens Junctions Regulates Epithelial Cell-Cell Contacts

(2008) Wenxiang Meng et al.   CELL

Adherens junctions

(2008) Noemi Rudini et al.   CURRENT BIOLOGY

Apical junction complex proteins and ulcerative colitis: a focus on thePTPRSgene

(2008) Aleixo Muise et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Mechanical factors activate ß‐catenin‐dependent oncogene expression in APC1638N/+ mouse colon

(2008) Joanne Whitehead et al.   HFSP Journal

Intestinal fibrosis in inflammatory bowel disease — Current knowledge and future perspectives

(2008) Florian Rieder et al.   Journal of Crohns & Colitis

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier

(2007) Juan Kong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

(2007) Andrea Hartsock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES