Review
Pediatrics
Asha Jois, George Alex
Summary: Inflammatory bowel disease is a common cause of chronic diarrhea in children and has been increasing worldwide. It includes different subtypes, such as Crohn's disease and ulcerative colitis. Diagnosis requires various investigations including imaging and endoscopy. Treatment depends on the severity and subtype, involving immunosuppressive therapies. Poorly controlled disease can lead to psychosocial impacts, growth impairment, and long-term risks. A multidisciplinary team is recommended for managing the disease. This review focuses on the latest clinical practices for diagnosis and management of inflammatory bowel disease in children.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Pharmacology & Pharmacy
Yang Zheng, Yang Yu, Xu-Feng Chen, Sheng-Lan Yang, Xiao-Long Tang, Zheng-Guo Xiang
Summary: Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders, with unclear mechanisms and lack of ideal treatments. Intestinal macrophage autophagy plays an important role in IBD, with potential implications for treatment by regulating inflammation and immune responses.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Lewis Steell, Stuart R. Gray, Richard K. Russell, Jonathan MacDonald, John Paul Seenan, Sze Choong Wong, Daniel R. Gaya
Summary: Musculoskeletal deficits are commonly reported in patients with inflammatory bowel disease (IBD), particularly Crohn's disease. The adverse effects on bone and muscle are multifactorial, including inflammation, nutritional deficits, and therapies, leading to increased risk of osteoporosis and sarcopenia. Ib children with IBD, these factors may impact optimal bone and muscle accrual.
Article
Gastroenterology & Hepatology
Hiroaki Okuno, Haruei Ogino, Eikichi Ihara, Kei Nishioka, Yoshimasa Tanaka, Takatoshi Chinen, Motoyuki Kohjima, Takamasa Oono, Masatake Tanaka, Takeshi Goya, Nao Fujimori, Yoichiro Iboshi, Takuji Gotoda, Yoshihiro Ogawa
Summary: The study investigated the pathological conditions of IBD-U, PSC-UC, and AIP-UC, and aimed to use mucosally expressed mediators as a discriminant equation to characterize these subtypes of UC. By measuring inflammatory mediators and using discriminant analysis and principal component analysis, it was found that specific combinations of inflammatory markers could accurately differentiate between UC and CD, as well as diagnose patients with IBD-U. Additionally, the distribution of inflammatory mediators suggested that PSC-UC and AIP-UC exhibited characteristics similar to CD and UC, respectively.
BMC GASTROENTEROLOGY
(2021)
Article
Nutrition & Dietetics
Julie Rempel, Kanika Grover, Wael El-Matary
Summary: Children and adolescents with inflammatory bowel disease (IBD) are at risk of developing anemia and various micronutrient deficiencies at diagnosis and one year follow-up. Factors such as age and albumin levels may play a role in predicting anemia in these patients.
Review
Biochemistry & Molecular Biology
Montse Baldan-Martin, Maria Chaparro, Javier P. Gisbert
Summary: Inflammatory bowel diseases (IBDs) are chronic and inflammatory conditions affecting the gastrointestinal tract. Despite endoscopy being the gold standard test for assessing IBD, it is invasive and uncomfortable for patients. Therefore, non-invasive biomarkers for IBD diagnosis are urgently needed. This review summarizes proteomics and metabolomics studies in animals and humans, identifying urinary biomarkers for IBD diagnosis. Large-scale multi-omics studies with collaboration between clinicians, researchers, and industry are necessary for the development of sensitive and specific diagnostic biomarkers for personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Susanna Esposito, Giulia Antoniol, Marialuisa Labate, Lucrezia Passadore, Patrizia Alvisi, Valeria Dacco, Chiara Ghizzi, Carla Colombo, Nicola Principi
Summary: The incidence of inflammatory bowel diseases (IBDs) is rising globally, leading to a higher risk of infections in children with dysfunctional immune systems. Vaccines are essential for preventing these infections, and should be administered according to specific immunization guidelines for IBD patients. Compliance with vaccination recommendations is generally low, highlighting the need for multidisciplinary educational programs to improve vaccination coverage and protect children with IBD from vaccine-preventable diseases.
Article
Gastroenterology & Hepatology
Charles N. Bernstein, Zoann Nugent, Seth Shaffer, Harminder Singh, Ruth Ann Marrie
Summary: Comorbidity is a significant predictor of disease course in IBD. The rates of certain component diseases of the Charlson Comorbidity Index were found to be increased both pre- and post-IBD diagnosis. Optimal care plans for persons with IBD should include assessment for a wide range of comorbidities involving multiple organ systems.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Federica Crispino, Mauro Grova, Erica Maria Bruno, Noemi Monachino, Giuseppe Rizzo, Angelo Casa, Sara Renna, Fabio Salvatore Macaluso, Ambrogio Orlando
Summary: Spondyloarthritis is a common extraintestinal manifestation of inflammatory bowel disease, and there is evidence of shared genetic and molecular pathways between the two diseases. Tumor necrosis factor antagonists are currently the mainstay of treatment, but other drugs such as ustekinumab and tofacitinib have also shown efficacy. However, the optimal use of these drugs in clinical practice remains challenging.
Review
Biochemistry & Molecular Biology
Yao Liu, Hui Yan, Bing Yu, Jun He, Xiangbing Mao, Jie Yu, Ping Zheng, Zhiqing Huang, Yuheng Luo, Junqiu Luo, Aimin Wu, Daiwen Chen
Summary: Inflammatory bowel disease (IBD) is a gastrointestinal disease that causes chronic tissue damage. The exact cause of IBD is unclear, but several risk factors have been identified. Immune system dysfunction and oxidative stress are hallmarks of IBD, and dietary intervention and medical treatment are recommended as potential therapies. Thymol, a natural compound, may have a protective effect on intestinal health.
Article
Microbiology
Christopher H. Arehart, John D. Sterrett, Rosanna L. Garris, Ruth E. Quispe-Pilco, Christopher R. Gignoux, Luke M. Evans, Maggie A. Stanislawski
Summary: Inflammatory bowel disease (IBD) is a complex condition with disrupted colonic ecosystem. A framework for multi-omic data analysis was used to study the gut ecosystem in IBD. Metabolomics and viromics were found to be more predictive than metagenomics or metatranscriptomics, and combining all four scores improved disease diagnosis prediction.
Article
Biochemistry & Molecular Biology
Aws Sadik, Christina Dardani, Panagiota Pagoni, Alexandra Havdahl, Evie Stergiakouli, Golam M. Khandaker, Sarah A. Sullivan, Stan Zammit, Hannah J. Jones, George Davey Smith, Christina Dalman, Hakan Karlsson, Renee M. Gardner, Dheeraj Rai
Summary: Evidence from multiple studies indicates a potential causal link between parental inflammatory bowel disease and autism in children. These studies utilized various methodologies and datasets to establish this association.
Article
Biochemistry & Molecular Biology
Paulina Krawiec, Elzbieta Pac-Kozuchowska
Summary: This study aimed to evaluate the level of serum elafin in children with inflammatory bowel disease (IBD) and its relationship with disease activity. The results showed that serum elafin levels were significantly elevated in children with IBD, especially during active phases. ROC analysis suggested that serum elafin could be a potential biomarker for ulcerative colitis.
Review
Chemistry, Multidisciplinary
Wanyue Fu, Lingling Xu, Zetong Chen, Lingling Kan, Yan Ma, Haisheng Qian, Wanni Wang
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, and nanomaterials have shown great potential in the diagnosis and treatment of IBD.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Gastroenterology & Hepatology
Paulina Nunez, Noa Krugliak Cleveland, Rodrigo Quera, David T. Rubin
Summary: Endoscopic evaluation plays a crucial role in predicting disease activity and severity in inflammatory bowel diseases, with mucosal healing associated with improved clinical outcomes and incorporated into standard care. Therapeutic endoscopic options and surveillance strategies, including early detection of neoplasia, continue to advance with evolving technology and visualization techniques.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Tal Berger, Huey Miin Lee, Lavenya Ramasamy Padmanaban, Eytan Wine, Anat Yerushalmy-Feler, Iva Hojsak, Denis Kazeka, Daniela Elena Serban, Dotan Yogev, Oren Ledder, Paolo Lionetti, Luca Scarallo, Marco Gasparetto, Nicholas M. Croft, Erasmo Miele, Annamaria Staiano, Joseph Meredith, Marina Aloi, Patrizia Alvisi, Darja Urlep, Batia Weiss, Mikkel Malham, Manar Matar, Victor Navas-Lopez, Claudio Romano, Valeria Dipasquale, Lorenzo Norsa, Kaija-Leena Kolho, Raanan Shamir, Dror Shouval
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Tal David Berger, Huey Miin Lee, Lavenya Ramasamy Padmanaban, Eytan Wine, Anat Yerushalmy-Feler, Iva Hojsak, Denis Kazeka, Daniela Elena Serban, Dotan Yogev, Oren Ledder, Paolo Lionetti, Luca Scarallo, Marco Gasparetto, Nicholas M. Croft, Erasmo Miele, Annamaria Staiano, Joseph Meredith, Marina Aloi, Patrizia Alvisi, Darja Urlep, Batia Weiss, Mikkel Malham, Manar Matar, Victor Manuel Navas-Lopez, Claudio Romano, Valeria Dipasquale, Lorenzo Norsa, Kaija-Leena Kolho, Raanan Shamir, Dror S. Shouval
Summary: Significant differences are observed in the clinical presentation and outcomes of paediatric patients with L2, compared to patients with L1 and UC. L2 patients have lower rates of hematochezia and fever, skip lesions in the intestines, and lower antibody positivity. Response rates to exclusive enteral nutrition and oral steroids are comparable between L1 and L2 patients, but L1 patients are commenced on anti-TNF alpha earlier. Moreover, stricturing phenotype and need for colectomy are very rare in L2 patients.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Pediatrics
Valeria Dipasquale, Massimo Martinelli, Marina Aloi, Salvatore Accomando, Patrizia Alvisi, Serena Arrigo, Claudia Banzato, Matteo Bramuzzo, Mara Cananzi, Mara Corpino, Clelia Di Mari, Giovanni Di Nardo, Anna Dilillo, Natale Dodaro, Enrico Felici, Simona Gatti, Francesco Graziano, Maria Teresa Illiceto, Lorenzo Norsa, Anna Opramolla, Maria Pastore, Paolo Maria Pavanello, Erminia Romeo, Luca Scarallo, Caterina Strisciuglio, Giovanna Zuin, Claudio Romano
Summary: The survey of members of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition showed high awareness and utilization of biosimilars in treating inflammatory bowel disease. Participants acknowledged similar efficacy and safety of biosimilars compared to originator drugs, with cost-saving being the main advantage. The majority reported switching from originator to biosimilars in their clinical practice with no significant adverse events, indicating a favorable and confident stance towards biosimilar use in pediatric IBD.
Article
Gastroenterology & Hepatology
Ohad Atia, Gemma Pujol-Muncunill, Victor Manuel Navas-Lopez, Esther Orlanski-Meyer, Oren Ledder, Raffi Lev-Tzion, Gili Focht, Eyal Shteyer, Ronen Stein, Marina Aloi, Richard K. Russell, Javier Martin-de-Carpi, Dan Turner
Summary: This study compared the treatment response to biologics in routine practice for children with inflammatory bowel diseases (IBD) who would and would not have been eligible for enrolment in the regulatory randomised controlled trials (RCTs) of the same drug. The results showed that most children initiating biologics for IBD in clinical practice would not have been eligible for the corresponding regulatory RCTs, and the outcomes of ineligible patients were worse than for eligible patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Marina Aloi, Giulia D'Arcangelo, Danilo Rossetti, Simone Bucherini, Enrico Felici, Claudio Romano, Massimo Martinelli, Valeria Dipasquale, Paolo Lionetti, Salvatore Oliva
Summary: This study investigated the association between pediatric inflammatory bowel disease (IBD) and eosinophilic esophagitis (EoE). The results suggest that having EoE may be associated with a milder IBD disease course.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Marialaura Cuomo, Alessandra Carobbio, Marina Aloi, Patrizia Alvisi, Claudia Banzato, Luca Bosa, Matteo Bramuzzo, Angelo Campanozzi, Giulia Catassi, Lorenzo D'Antiga, Monica Di Paola, Enrico Felici, Maria Teresa Fioretti, Simona Gatti, Francesco Graziano, Sara Lega, Paolo Lionetti, Antonio Marseglia, Massimo Martinelli, Francesca Musto, Naire Sansotta, Luca Scarallo, Giovanna Zuin, Lorenzo Norsa
Summary: Exclusive enteral nutrition is the first choice for inducing remission in pediatric Crohn's disease, but adherence to this treatment can be challenging for children. This study aimed to identify factors predictive of nonadherence and nonremission. The results showed that colonic involvement and high fecal calprotectin levels at diagnosis were associated with reduced adherence to exclusive enteral nutrition.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Anat Yerushalmy-Feler, Gemma Pujol-Muncunill, Javier Martin-de-Carpi, Kaija-Leena Kolho, Arie Levine, Christine Olbjorn, Maya Granot, Matteo Bramuzzo, Helena Rolandsdotter, Natalia Mouratidou, Ondrej Hradsky, Luca Scarallo, Manar Matar, Ramit Magen Rimon, Firas Rinawi, Tzippi Shalem, Hisham Najajra, Tim de Meij, Marina Aloi, Marta Velasco Rodriguez-Belvis, Patrizia Alvisi, Anna-Maria Schneider, Patrick van Rheenen, Victor Manuel Navas-Lopez, Fevronia Kiparissi, Josefa Barrio, Dan Turner, Shlomi Cohen
Summary: Dose escalation of UST is effective in children with Crohn disease, and milder disease activity may predict a favorable outcome following UST dose escalation.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Ohad Atia, Zivia Shavit-Brunschwig, Diane R. Mould, Ronen Stein, Manar Matar, Marina Aloi, Oren Ledder, Gili Focht, Darja Urlep, Jeffrey Hyams, Efrat Broide, Batia Weiss, Jeremiah Levine, Richard K. Russell, Dan Turner
Summary: This study evaluated the safety, effectiveness, and dosing of vedolizumab in children with inflammatory bowel disease (IBD). The results showed that vedolizumab had good efficacy in inducing remission in children with IBD, especially those with ulcerative colitis. For children weighing less than 30 kg, a dose of 200 mg/m2 or 10 mg/kg at week 14 was recommended. The importance rating for this study is 8 out of 10.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Davide Selvestrel, Gabriele Stocco, Marina Aloi, Serena Arrigo, Sabrina Cardile, Erika Cecchin, Mauro Congia, Debora Curci, Simona Gatti, Francesco Graziano, Carl D. Langefeld, Marianna Lucafo, Stefano Martelossi, Massimo Martinelli, Sofia Pagarin, Luca Scarallo, Elisabetta Francesca Stacul, Caterina Strisciuglio, Susan Thompson, Giovanna Zuin, Giuliana Decorti, Matteo Bramuzzo
Summary: This pharmacoepigenetic study aims to evaluate differences in DNA methylation and TPMT activity between patients with very early onset inflammatory bowel disease (VEO-IBD) and adolescents with IBD (aIBD). The study found that the DNA methylation level of cg22736354 in the TPMT gene neighborhood is lower in VEO-IBD patients, and it is associated with TPMT activity and azathioprine concentration.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Gastroenterology & Hepatology
Lihi Godny, Vaios Svolos, Astrid-Jane Williams, Wladyslawa Czuber-Dochan, Marina Aloi, Ana Ibarra, Dearbhaile O'Hanlon, Gabriele Dragoni, Irit Avni Biron, Marjo Campmans-Kuijpers, Paul Collins, Piotr Eder, Tamar Pfeffer-Gik, Susanna Jaghult, Catherine L. Wall
Summary: This topical review assessed the non-medical management of patients with inflammatory bowel disease (IBD) during the perinatal period. A consensus expert panel developed 19 practice positions covering preconception, pregnancy, lactation, and early-life exposures. The results indicated that patients with IBD have unique nutritional and psychosocial needs, and the early-life environment of infants born to parents with IBD may be associated with the development of IBD in offspring.
JOURNAL OF CROHNS & COLITIS
(2023)
Correction
Gastroenterology & Hepatology
Marina Aloi, Giulia D'Arcangelo, Danilo Rossetti, Simone Bucherini, Enrico Felici, Claudio Romano, Massimo Martinelli, Valeria Dipasquale, Paolo Lionetti, Salvatore Oliva
INFLAMMATORY BOWEL DISEASES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Zivia Shavit-Brunschwig, Ronen E. Stein, Marina Aloi, Oren Ledder, Gili Focht, Darja Urlep, Jeffrey S. Hyams, Efrat Broide, Batia Weiss, Jeremiah Levine, Dror Shouval, Manar Matar, Amit Assa, Joel R. Rosh, Seamus Hussey, James Markowitz, Anat Yerushalmy-Feler, Erasmo Miele, Ron Shaoul, Richard K. Russell, Dan Turner
Meeting Abstract
Gastroenterology & Hepatology
Salvatore Oliva, Silvio Veraldi, Gian Eugenio Tontini, Pinhas Eidler, Luca Elli, Marina Aloi, Patrizia Alvisi, Virginia Lombardo, Nikolas Dussias, Paolo Gionchetti, Carlo Calabrese
GASTROINTESTINAL ENDOSCOPY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Tal Berger, Huey Miin Lee, Lavenya Ramasamy Padmanaban, Eytan Wine, Anat Yerushalmy-Feler, Iva Hojsak, Denis Kazeka, Daniela Elena Serban, Dotan Yogev, Oren Ledder, Paolo Lionetti, Luca Scarallo, Marco Gasparetto, Nicholas M. Croft, Erasmo Miele, Annamaria Staiano, Joseph Meredith, Marina Aloi, Patrizia Alvisi, Darja Urlep, Batia Weiss, Mikkel Malham, Manar Matar, Victor Navas-Lopez, Claudio Romano, Valeria Dipasquale, Lorenzo Norsa, Kaija-Leena Kolho, Raanan Shamir, Dror Shouval
Meeting Abstract
Gastroenterology & Hepatology
Muhammad Waqas Tahir, Raseen Tariq, Zoya Tahir, Arsalan Zaheer, Sahil Khanna