Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease
Published 2015 View Full Article
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Title
Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease
Authors
Keywords
Inflammatory bowel disease, Intestinal stem cells, Paneth cells, Goblet cells, Organoids, Stem cell transplantation
Journal
JOURNAL OF GASTROENTEROLOGY
Volume 51, Issue 1, Pages 11-21
Publisher
Springer Nature
Online
2015-07-02
DOI
10.1007/s00535-015-1098-4
References
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Note: Only part of the references are listed.- RIPK3 regulates p62–LC3 complex formation via the caspase-8-dependent cleavage of p62
- (2015) Yu Matsuzawa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts
- (2015) Jurian Schuijers et al. Cell Stem Cell
- Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease
- (2015) R. Sancho et al. EMBO REPORTS
- The microbiota in inflammatory bowel disease
- (2015) Donal Sheehan et al. JOURNAL OF GASTROENTEROLOGY
- Stem cell therapy for inflammatory bowel disease
- (2015) Kanna Nagaishi et al. JOURNAL OF GASTROENTEROLOGY
- New developments in goblet cell mucus secretion and function
- (2015) G M H Birchenough et al. Mucosal Immunology
- A gp130–Src–YAP module links inflammation to epithelial regeneration
- (2015) Koji Taniguchi et al. NATURE
- Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies
- (2015) James A. Heslop et al. Stem Cells Translational Medicine
- Dissecting Engineered Cell Types and Enhancing Cell Fate Conversion via CellNet
- (2014) Samantha A. Morris et al. CELL
- Colitis-associated neoplasia: molecular basis and clinical translation
- (2014) Sebastian Foersch et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon
- (2014) Masayoshi Fukuda et al. GENES & DEVELOPMENT
- The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
- (2014) W. de Lau et al. GENES & DEVELOPMENT
- Long-lived intestinal tuft cells serve as colon cancer–initiating cells
- (2014) C. Benedikt Westphalen et al. JOURNAL OF CLINICAL INVESTIGATION
- The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications
- (2014) Jason R. Goldsmith et al. JOURNAL OF GASTROENTEROLOGY
- A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3
- (2014) Aditya Murthy et al. NATURE
- Stressful genetics in Crohn's disease
- (2014) Arthur Kaser et al. NATURE
- Japan stem-cell trial stirs envy
- (2014) Sara Reardon et al. NATURE
- An in vivo model of human small intestine using pluripotent stem cells
- (2014) Carey L Watson et al. NATURE MEDICINE
- Myosin Light Chain Kinase Expression Induced via Tumor Necrosis Factor Receptor 2 Signaling in the Epithelial Cells Regulates the Development of Colitis-Associated Carcinogenesis
- (2014) Masahiro Suzuki et al. PLoS One
- Surface area of the digestive tract – revisited
- (2014) Herbert F Helander et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
- (2014) H. Clevers et al. SCIENCE
- Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine
- (2014) Hiromichi Shimizu et al. PeerJ
- Paneth Cells: Maestros of the Small Intestinal Crypts
- (2013) Hans C. Clevers et al. Annual Review of Physiology
- The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein
- (2013) Yoshihito Kano et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells
- (2013) Tatsuro Murano et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury
- (2013) Robert P. Fordham et al. Cell Stem Cell
- Overcoming Challenges in IBD Management: Management of Colonic Dysplastic Lesions
- (2013) Maria Pellisé DIGESTIVE DISEASES
- Combined oral and rectal mesalazine for the treatment of mild-to-moderately active ulcerative colitis: Rapid symptom resolution and improvements in quality of life
- (2013) Christopher S.J. Probert et al. Journal of Crohns & Colitis
- Normal mucus formation requires cAMP-dependent HCO3−secretion and Ca2+-mediated mucin exocytosis
- (2013) Ning Yang et al. JOURNAL OF PHYSIOLOGY-LONDON
- Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
- (2013) Andrew S Lee et al. NATURE MEDICINE
- Lineage-Specific Expression of Bestrophin-2 and Bestrophin-4 in Human Intestinal Epithelial Cells
- (2013) Go Ito et al. PLoS One
- Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications
- (2013) T. Sato et al. SCIENCE
- Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics
- (2013) Luca Pastorelli et al. Frontiers in Immunology
- Notch in the Intestine: Regulation of Homeostasis and Pathogenesis
- (2012) Taeko K. Noah et al. Annual Review of Physiology
- Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
- (2012) Sarah Schwitalla et al. CELL
- The impact of infliximab induction therapy on mucosal healing and clinical remission in Polish pediatric patients with moderate-to-severe Crohn’s disease
- (2012) Jarosław Kierkus et al. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
- Adalimumab Induces and Maintains Mucosal Healing in Patients With Crohn's Disease: Data From the EXTEND Trial
- (2012) Paul Rutgeerts et al. GASTROENTEROLOGY
- Mucosal healing in inflammatory bowel diseases: a systematic review
- (2012) Markus F Neurath et al. GUT
- Healing of intestinal inflammation by IL-22
- (2012) Atsushi Mizoguchi INFLAMMATORY BOWEL DISEASES
- Interleukin-6 - A Key Regulator of Colorectal Cancer Development
- (2012) Maximilian J. Waldner et al. International Journal of Biological Sciences
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- (2012) Jeremiah R. McDole et al. NATURE
- Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
- (2012) Bon-Kyoung Koo et al. NATURE
- Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
- (2012) Johan H. van Es et al. NATURE CELL BIOLOGY
- Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell
- (2012) Shiro Yui et al. NATURE MEDICINE
- Wnt5a Potentiates TGF- Signaling to Promote Colonic Crypt Regeneration After Tissue Injury
- (2012) H. Miyoshi et al. SCIENCE
- Inflammation and colorectal cancer: colitis-associated neoplasia
- (2012) Sergei I. Grivennikov Seminars in Immunopathology
- Randomised clinical trial: delayed-release oral mesalazine 4.8 g/day vs. 2.4 g/day in endoscopic mucosal healing - ASCEND I and II combined analysis
- (2011) G. R. Lichtenstein et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
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- (2011) Alexander C Ford et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
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- (2011) Sandro Ardizzone et al. Clinical Gastroenterology and Hepatology
- Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells
- (2011) K. L. VanDussen et al. DEVELOPMENT
- LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling
- (2011) Andrei Glinka et al. EMBO REPORTS
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- (2011) Luca Pellegrinet et al. GASTROENTEROLOGY
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- (2011) Jean Frédéric Colombel et al. GASTROENTEROLOGY
- Notch: Architect, Landscaper, and Guardian of the Intestine
- (2011) Marc Vooijs et al. GASTROENTEROLOGY
- Results from the 2nd Scientific Workshop of the ECCO (I): Impact of mucosal healing on the course of inflammatory bowel disease
- (2011) Laurent Peyrin-Biroulet et al. Journal of Crohns & Colitis
- Mesalazine in left-sided ulcerative colitis: Efficacy analyses from the PODIUM trial on maintenance of remission and mucosal healing
- (2011) Bernd Bokemeyer et al. Journal of Crohns & Colitis
- Risk factors in the development of stem cell therapy
- (2011) Carla A Herberts et al. Journal of Translational Medicine
- Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis
- (2011) Claudia Günther et al. NATURE
- Intestinal homeostasis and its breakdown in inflammatory bowel disease
- (2011) Kevin J. Maloy et al. NATURE
- Genetics and pathogenesis of inflammatory bowel disease
- (2011) Bernard Khor et al. NATURE
- The Antibacterial Lectin RegIII Promotes the Spatial Segregation of Microbiota and Host in the Intestine
- (2011) S. Vaishnava et al. SCIENCE
- Inflammatory Bowel Disease
- (2010) Arthur Kaser et al. Annual Review of Immunology
- Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells
- (2010) Hugo J. Snippert et al. CELL
- Crohn's Disease Susceptibility Gene Interactions, a NOD to the Newcomer ATG16L1
- (2010) Ken Cadwell GASTROENTEROLOGY
- Intestinal growth factors: Potential use in the treatment of inflammatory bowel disease and their role in mucosal healing
- (2010) Kumar Krishnan et al. INFLAMMATORY BOWEL DISEASES
- Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon
- (2010) Kuai Yu et al. JOURNAL OF CLINICAL INVESTIGATION
- Involvement of the IL-22/REG Iα axis in ulcerative colitis
- (2010) Akira Sekikawa et al. LABORATORY INVESTIGATION
- Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
- (2010) Toshiro Sato et al. NATURE
- Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
- (2010) Jason R. Spence et al. NATURE
- Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
- (2010) Andre Franke et al. NATURE GENETICS
- Biology of interleukin-22
- (2010) Kerstin Wolk et al. Seminars in Immunopathology
- Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors
- (2010) Johan H. van Es et al. Nature Communications
- Signaling pathway via TNF-α/NF-κB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis
- (2009) Michio Onizawa et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn disease
- (2009) Ken Cadwell et al. Autophagy
- gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis
- (2009) Julia Bollrath et al. CANCER CELL
- Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate
- (2009) Laurens G. van der Flier et al. CELL
- IKK/NF-κB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis
- (2009) Julia Bollrath et al. EMBO REPORTS
- Effect of EP4 agonist (ONO-4819CD) for patients with mild to moderate ulcerative colitis refractory to 5-aminosalicylates: A randomized phase II, placebo-controlled trial
- (2009) Hiroshi Nakase et al. INFLAMMATORY BOWEL DISEASES
- Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohnʼs disease
- (2009) Alan L. Buchman et al. INFLAMMATORY BOWEL DISEASES
- Importance of mucosal healing in ulcerative colitis
- (2009) Gary R. Lichtenstein et al. INFLAMMATORY BOWEL DISEASES
- STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
- (2009) Geethanjali Pickert et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells
- (2009) Minekazu Murayama et al. JOURNAL OF GASTROENTEROLOGY
- Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
- (2009) Toshiro Sato et al. NATURE
- Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
- (2009) Akifumi Ootani et al. NATURE MEDICINE
- Requirement of Notch activation during regeneration of the intestinal epithelia
- (2008) Ryuichi Okamoto et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium
- (2008) Laurens G. van der Flier et al. Annual Review of Physiology
- Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2
- (2008) Orbicia Riccio et al. EMBO REPORTS
- Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis
- (2008) Liping Su et al. GASTROENTEROLOGY
- A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
- (2008) Ken Cadwell et al. NATURE
- Crypt stem cells as the cells-of-origin of intestinal cancer
- (2008) Nick Barker et al. NATURE
- Endoscopic and chromoendoscopic atlas featuring dysplastic lesions in surveillance colonoscopy for patients with long-standing ulcerative colitis
- (2007) Takayuki Matsumoto et al. INFLAMMATORY BOWEL DISEASES
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