The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent

Urolithin A‐activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo

(2019) Anil Ahsan et al.   CNS Neuroscience & Therapeutics

Urolithin A induces prostate cancer cell death in p53-dependent and in p53-independent manner

(2019) Yasir I. Mohammed Saleem et al.   EUROPEAN JOURNAL OF NUTRITION

Protective effect of urolithin a on cisplatin-induced nephrotoxicity in mice via modulation of inflammation and oxidative stress

(2019) Taile Jing et al.   FOOD AND CHEMICAL TOXICOLOGY

Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis

(2019) Feng Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Regulation of redox status in neuronal SH-SY5Y cells by blueberry ( Vaccinium myrtillus L.) juice, cranberry ( Vaccinium macrocarpon A.) juice and cyanidin

(2018) Guillermo Cásedas et al.   FOOD AND CHEMICAL TOXICOLOGY

Pomegranate polyphenols and urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells

(2018) Francisco Les et al.   JOURNAL OF ETHNOPHARMACOLOGY

Combinatorial Preconditioning of Rat Brain Cultures with Subprotective Ethanol and Resveratrol Concentrations Promotes Synergistic Neuroprotection

(2018) N. Khodaie et al.   NEUROTOXICITY RESEARCH

Sour cherry ( Prunus cerasus L.) juice protects against hydrogen peroxide-induced neurotoxicity by modulating the antioxidant response

(2018) Guillermo Cásedas et al.   Journal of Functional Foods

Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid

(2017) Jacqueline Heilman et al.   FOOD AND CHEMICAL TOXICOLOGY

Antimelanogenic Effect of Urolithin A and Urolithin B, the Colonic Metabolites of Ellagic Acid, in B16 Melanoma Cells

(2017) Shang-Ta Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract

(2017) Rocío García-Villalba et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial

(2017) Antonio González-Sarrías et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

(2016) Francisco A. Tomás-Barberán et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Memory-vitalizing effect of twenty-five medicinal and edible plants and their isolated compounds

(2016) F. Sezer Senol et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Pomegranate’s Neuroprotective Effects against Alzheimer’s Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites

(2015) Tao Yuan et al.   ACS Chemical Neuroscience

Antioxidant Capacity of “Mexican Arnica”Heterotheca inuloidesCass Natural Products and Some Derivatives: Their Anti-Inflammatory Evaluation and Effect onC. elegansLife Span

(2015) José Luis Rodríguez-Chávez et al.   Oxidative Medicine and Cellular Longevity

In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells

(2015) Yun Wang et al.   TOXICOLOGY IN VITRO

Bioactive properties of commercialised pomegranate (Punica granatum) juice: antioxidant, antiproliferative and enzyme inhibiting activities

(2015) Francisco Les et al.   Food & Function

Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors

(2014) Hayrettin Ozan Gulcan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints

(2013) Susan Y. Bookheimer et al.   Evidence-based Complementary and Alternative Medicine

In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells

(2013) Zhenpeng Qiu et al.   FOOD AND CHEMICAL TOXICOLOGY

Urolithins Display both Antioxidant and Pro-oxidant Activities Depending on Assay System and Conditions

(2013) Tuija Kallio et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Kaurane diterpenes from Sideritis spp. exert a cytoprotective effect against oxidative injury that is associated with modulation of the Nrf2 system

(2013) E. González-Burgos et al.   PHYTOCHEMISTRY

Cu(I)-mediated lactone formation in subcritical water: a benign synthesis of benzopyranones and urolithins A–C

(2013) Prattya Nealmongkol et al.   TETRAHEDRON

Antioxidative Properties of Functional Polyphenols and Their Metabolites Assessed by an ORAC Assay

(2012) Hidekazu ISHIMOTO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Metabolites of the Ellagitannin Geraniin and Their Antioxidant Activities

(2011) Hideyuki Ito   PLANTA MEDICA

Urolithins, Intestinal Microbial Metabolites of Pomegranate Ellagitannins, Exhibit Potent Antioxidant Activity in a Cell-Based Assay

(2009) Dobroslawa Bialonska et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The peroxidase and peroxynitrite reductase activity of human erythrocyte peroxiredoxin 2

(2008) Bruno Manta et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Isolation of the MAO-inhibitor naringenin from Mentha aquatica L.

(2008) Helle T. Olsen et al.   JOURNAL OF ETHNOPHARMACOLOGY