Antioxidant Therapy in Parkinson’s Disease: Insights from Drosophila melanogaster

An assessment of the translational relevance of Drosophila in drug discovery

(2019) Katerina Papanikolopoulou et al.   Expert Opinion on Drug Discovery

Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila

(2019) Hagar Meltzer et al.   Nature Communications

Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process

(2018) Amin Karimi-Moghadam et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss

(2018) Alice Biosa et al.   HUMAN MOLECULAR GENETICS

Epigallocatechin-3-Gallate Protects and Prevents Paraquat-Induced Oxidative Stress and Neurodegeneration in Knockdown dj-1-β Drosophila melanogaster

(2018) Daniel A. Martinez-Perez et al.   NEUROTOXICITY RESEARCH

A gene-specific T2A-GAL4 library for Drosophila

(2018) Pei-Tseng Lee et al.   eLife

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease

(2018) Géraldine Gelders et al.   Journal of Immunology Research

Changes in Glutathione Redox Potential Are Linked to Aβ42-Induced Neurotoxicity

(2018) Zeenna A. Stapper et al.   Cell Reports

Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease

(2018) Federica De Lazzari et al.   Aging and Disease

Drosophila as a Model to Study Brain Innate Immunity in Health and Disease

(2018) Shu Lye et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circadian Rhythm Abnormalities in Parkinson’s Disease from Humans to Flies and Back

(2018) Federica De Lazzari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of potential therapeutic compounds for Parkinson's disease using Drosophila and human cell models

(2017) Francisco José Sanz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Taking Stock of the Drosophila Research Ecosystem

(2017) David Bilder et al.   GENETICS

From Mitochondrial Function to Neuroprotection—an Emerging Role for Methylene Blue

(2017) Donovan Tucker et al.   MOLECULAR NEUROBIOLOGY

The two-century journey of Parkinson disease research

(2017) Serge Przedborski   NATURE REVIEWS NEUROSCIENCE

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease

(2017) Alice Biosa et al.   NEUROBIOLOGY OF DISEASE

Taking Stock of the Drosophila Research Ecosystem

(2017) David Bilder et al.   GENETICS

Anti-Oxidants in Parkinson's Disease Therapy: A Critical Point of View

(2016) Roberta Filograna et al.   Current Neuropharmacology

Medical Application ofSpirulina platensisDerived C-Phycocyanin

(2016) Qian Liu et al.   Evidence-based Complementary and Alternative Medicine

Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity

(2016) Roberta Filograna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genome-wide resource for the analysis of protein localisation in Drosophila

(2016) Mihail Sarov et al.   eLife

Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease

(2015) Dominik Haddad et al.   FEBS LETTERS

Fruit Flies in Biomedical Research

(2015) M. F. Wangler et al.   GENETICS

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Attenuation of neuromotor deficits by natural antioxidants of Decalepis hamiltonii in transgenic Drosophila model of Parkinson’s disease

(2015) S.R. Jahromi et al.   NEUROSCIENCE

The Synaptic Function of α-Synuclein

(2015) Jacqueline Burré   Journal of Parkinsons Disease

Are dopamine derivatives implicated in the pathogenesis of Parkinson's disease?

(2014) Marco Bisaglia et al.   AGEING RESEARCH REVIEWS

Dopamine Dynamics and Signaling in Drosophila: An Overview of Genes, Drugs and Behavioral Paradigms

(2014) Shinya Yamamoto et al.   EXPERIMENTAL ANIMALS

Quantitative Analysis of Major Constituents in Green Tea with Different Plucking Periods and Their Antioxidant Activity

(2014) Lan-Sook Lee et al.   MOLECULES

FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations

(2014) G. dos Santos et al.   NUCLEIC ACIDS RESEARCH

Effect of Curcumin on Lifespan, Activity Pattern, Oxidative Stress, and Apoptosis in the Brains of TransgenicDrosophilaModel of Parkinson’s Disease

(2014) Yasir Hasan Siddique et al.   Biomed Research International

Effect ofCentella asiaticaLeaf Extract on the Dietary Supplementation in TransgenicDrosophilaModel of Parkinson’s Disease

(2014) Yasir Hasan Siddique et al.   Parkinsons Disease

GC–MS analysis of Eucalyptus citriodora leaf extract and its role on the dietary supplementation in transgenic Drosophila model of Parkinson’s disease

(2013) Yasir Hasan Siddique et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant compound supplementation prevents oxidative damage in a Drosophila model of Parkinson's disease

(2013) Sandra Casani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence

(2013) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease

(2013) Scott J. Gratz et al.   GENETICS

Highly Improved Gene Targeting by Germline-Specific Cas9 Expression in Drosophila

(2013) Shu Kondo et al.   GENETICS

Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila

(2013) Z. Yu et al.   GENETICS

Anti-oxidant activity of holo- and apo-c-phycocyanin and their protective effects on human erythrocytes

(2013) Pornthip Pleonsil et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A Review of Pterostilbene Antioxidant Activity and Disease Modification

(2013) Denise McCormack et al.   Oxidative Medicine and Cellular Longevity

Genetically Encoded Fluorescent Redox Probes

(2013) Wei Ren et al.   SENSORS

Clinical and Experimental Applications of Sodium Phenylbutyrate

(2013) Tommaso Iannitti et al.   Drugs in research & development

Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System

(2013) Andrew R. Bassett et al.   Cell Reports

Parkinson's Disease and Parkinsonism: Neuropathology

(2013) D. W. Dickson   Cold Spring Harbor Perspectives in Medicine

dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster

(2012) Rhoda Stefanatos et al.   CELL CYCLE

Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: Implication in autosomal recessive juvenile Parkinsonism

(2012) Leonardo Bonilla-Ramirez et al.   GENE

Efficient and Specific Modifications of the Drosophila Genome by Means of an Easy TALEN Strategy

(2012) Jiyong Liu et al.   Journal of Genetics and Genomics

Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening

(2012) Emilie Giaime et al.   PLoS One

Methods to Assay Drosophila Behavior

(2012) Charles D. Nichols et al.   Jove-Journal of Visualized Experiments

In Vivo Mapping of Hydrogen Peroxide and Oxidized Glutathione Reveals Chemical and Regional Specificity of Redox Homeostasis

(2011) Simone C. Albrecht et al.   Cell Metabolism

TheDrosophilaGene Disruption Project: Progress Using Transposons With Distinctive Site Specificities

(2011) Hugo J. Bellen et al.   GENETICS

MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes

(2011) Koen J T Venken et al.   NATURE METHODS

Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis

(2011) Zhaohui Liu et al.   NEUROBIOLOGY OF DISEASE

Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

(2011) U. B. Pandey et al.   PHARMACOLOGICAL REVIEWS

Molecular mechanisms of pesticide-induced neurotoxicity: Relevance to Parkinson's disease

(2010) Rodrigo Franco et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of pharmacological agents on the lifespan phenotype of Drosophila DJ-1β mutants

(2010) Eusebio Lavara-Culebras et al.   GENE

In vitro and in vivo study on the antioxidant activity of dexrazoxane

(2009) Fabio Galetta et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease

(2009) Katharina Faust et al.   BMC NEUROSCIENCE

Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

(2009) K. Venderova et al.   HUMAN MOLECULAR GENETICS

Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila

(2009) C.-H. Ng et al.   JOURNAL OF NEUROSCIENCE

A toolkit for high-throughput, cross-species gene engineering in Drosophila

(2009) Radoslaw K Ejsmont et al.   NATURE METHODS

Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster

(2009) Koen J T Venken et al.   NATURE METHODS

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

(2009) Luke S Tain et al.   NATURE NEUROSCIENCE

Drosophotoxicology: The growing potential for Drosophila in neurotoxicology

(2009) Matthew D. Rand   NEUROTOXICOLOGY AND TERATOLOGY

Grape Extract Protects Mitochondria from Oxidative Damage and Improves Locomotor Dysfunction and Extends Lifespan in a Drosophila Parkinson's Disease Model

(2009) Jiangang Long et al.   REJUVENATION RESEARCH

Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity

(2009) Zhengmei Mao   Frontiers in Neural Circuits

Efficacy of Superoxide Dismutase Mimetic M40403 in Attenuating Radiation-Induced Oral Mucositis in Hamsters

(2008) C. K. Murphy et al.   CLINICAL CANCER RESEARCH

Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson's Disease

(2008) K. Trinh et al.   JOURNAL OF NEUROSCIENCE

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

(2008) Danling Wang et al.   Molecular Neurodegeneration

Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease

(2008) Jose A. Botella et al.   NEUROBIOLOGY OF DISEASE

Drosophila D1 dopamine receptor mediates caffeine-induced arousal

(2008) R. Andretic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Drosophila model for LRRK2-linked parkinsonism

(2008) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hormesis defined

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS