Journal
SENSORS
Volume 13, Issue 11, Pages 15422-15433Publisher
MDPI
DOI: 10.3390/s131115422
Keywords
redox signaling; fluorescent protein (FP)-based sensors; reaction-based probes; unnatural amino acids (UAAs); redox probes
Funding
- University of California-Riverside
- UCR Academic Senate
- Chinese American Faculty Association of South California
- Hellman Fellows Fund
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Redox processes are involved in almost every cell of the body as a consequence of aerobic life. In the past decades, redox biology has been increasingly recognized as one of the key themes in cell signaling. The progress has been accelerated by development of fluorescent probes that can monitor redox conditions and dynamics in cells and cell compartments. This short paper focuses on fluorescent redox probes that are genetically encoded, and discusses their properties, molecular mechanism, advantages and pitfalls. Our recent work on reaction-based encoded probes that are responsive to particular redox signaling molecules is also reviewed. Future challenges and directions are also commented.
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