Article
Integrative & Complementary Medicine
Tanita Pairojana, Sarayut Phasuk, Mayuree H. Tantisira, Kai-Chi Liang, Sittiruk Roytrakul, Narawut Pakaprot, Supin Chompoopong, Sutisa Nudmamud-Thanoi, Yang Ming, Ingrid Y. Liu
Summary: ECa 233 is a standardized extract from Centella asiatica, known for its memory-enhancing properties. In this study, the researchers investigated the therapeutic effect of ECa 233 on fear memory deficit in a mouse model of Alzheimer's disease. The results showed that ECa 233 prevented fear memory deficits and improved synaptic plasticity in the mice, suggesting its potential as a herbal treatment for early-onset Alzheimer's disease.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Plant Sciences
Srinivasan Ragupathi, Anbarasi Gunasekar, Nayana Chathalingath, Tharangini priya Mohan
Summary: The study focuses on the effectiveness of methanolic extract of Centella asiatica against sodium arsenate-induced hepatotoxicity in Zebrafish. The extract showed significant antioxidant and antibacterial activities, and could alleviate the liver damage caused by sodium arsenate.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Plant Sciences
Ritesh Kumar, Renu Arora, Sudhir Chandra Sarangi, Shankar N. Ganeshan, Amit Agarwal, Thomas Kaleekal, Yogendra Kumar Gupta
Summary: The study found that co-administration of HECA could enhance the therapeutic efficacy of VPA and PHT in treating epilepsy, but changes in pharmacokinetic parameters require strict medical supervision to prevent toxic reactions.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Eun Kim, Jun Soo Park, Min Seop Kim, Min Young Jeong, Hyun Jin Park, Jun Hyuk Choi, Jae Hee Seo, Yong Seok Choi, Myung Joo Kang
Summary: This study successfully designed a high-payload topical preparation of Centella asiatica using nanocrystallization technique, which showed higher accumulation in the skin layer and better skin absorption profile, with no signs of irritation in normal rats.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Environmental Sciences
Irmak Ferah Okkay, Ufuk Okkay, Ismail Cagri Aydin, Cemil Bayram, Muhammed Sait Ertugrul, Ali Sefa Mendil, Ahmet Hacimuftuoglu
Summary: This study found that Centella asiatica can alleviate cisplatin-induced hepatotoxicity through its antioxidant, anti-inflammatory, and anti-apoptotic activities.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
P. Mohammed Yusuf Ansari, R. M. Muthukrishnan, C. Vedhi, K. Sakthipandi, S. M. Abdul Kader
Summary: This research synthesized copper metal nanoparticles using a green-synthesis method with Centella asiatica leaf extract and perovskite-structured bismuth ferrite nanomaterial. The synthesized nanoparticles demonstrated good structural, optical, and morphological properties, and showed high sensitivity in sugar-sensing activities, making them suitable for glucose sugar sensor applications.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Physiology
Aqilah Hambali, Jaya Kumar, Nur Fariesha Md Hashim, Sandra Maniam, Muhammad Zulfadli Mehat, Manraj Singh Cheema, Muzaimi Mustapha, Mohd Ilham Adenan, Johnson Stanslas, Hafizah Abdul Hamid
Summary: Neuroinflammation is closely associated with the susceptibility and progression of Alzheimer's disease, induced by chronic hypoxia activating immune cells in the brain. Plant derivatives, such as Centella asiatica, show potential as therapeutic agents for Alzheimer's disease through targeting the hypoxia-neuroinflammation pathway.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Physical
T. Sabeetha, M. V. Leena Chandra, S. Selvasekarapandian, N. Muniraj Vignesh, R. Meera Naachiyar, S. Aafrin Hazaana
Summary: Biomaterial, Centella Asiatica Leaf (CAL), has been developed as a bio-membrane electrolyte for proton conducting electrochemical devices. The prepared bio-membranes possess high proton conductivity and good thermal stability. The highest conducting bio-membrane exhibits a tensile strength, electrochemical stability, and performance in proton battery and fuel cell applications.
Article
Multidisciplinary Sciences
Visarut Buranasudja, Dolly Rani, Ashwini Malla, Khwanlada Kobtrakul, Sornkanok Vimolmangkang
Summary: Formation of oxidative stress in dermal fibroblasts is crucial for skin aging, and using phytochemicals to enhance the cells' ability to combat oxidative stress is a promising strategy to prevent skin aging. Callus culture of Centella asiatica produces unique antioxidant compounds that exhibit anti-skin-aging activities, including upregulation of cellular antioxidant enzymes and inhibition of matrix metalloprotease-9 induction. This highlights the potential of C. asiatica callus extract as an effective anti-skin-aging agent in cosmeceutical preparations.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Dwi Cahyani Ratna Sari, Santosa Budiharjo, Husnari Afifah, Destantry Jasmin, Orisativa Kokasih, Tiara Gitami Putri, Karina Arifiani, Wiwit Ananda Wahyu Setyaningsih, Nur Arfian
Summary: CeA treatment in UUO mice model effectively ameliorated kidney fibrosis by reducing interstitial fibrosis area, suppressing organ injury, and regulating the expression of various genes, which resulted in decreased inflammation and mesenchymal transition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Vilasinee Sanguansajapong, Pajaree Sakdiset, Panupong Puttarak
Summary: Several publications have shown that Centella asiatica and its active constituents, pentacyclic triterpenes, have positive effects on wound healing. In this study, a microwave-assisted extraction (MAE) method was used to prepare a pentacyclic triterpenes-rich extract from Centella asiatica. The extract showed strong anti-inflammatory activity and fibroblast proliferative effect. A microemulsion was formulated using the extract and was evaluated for its effects on cell proliferation, migration, and collagen production. The microemulsion containing 1% of the extract showed the highest efficacy in promoting cell proliferation, migration, and collagen production, making it a suitable oral spray formulation for oral ulcer treatment.
Article
Nutrition & Dietetics
Jingbin Li, Yang He, Jia Fu, Yimin Wang, Xing Fan, Tian Zhong, Hui Zhou
Summary: In this study, the protective effects of Acanthopanax senticosus extract (ASE) on MPTP-induced Parkinson's disease (PD) were investigated. ASE significantly improved motor coordination in mice with MPTP-induced PD. Proteomic analysis revealed that ASE modulated the expression of multiple proteins involved in Fc gamma receptor-mediated phagocytosis, PI3K/AKT signaling, and insulin receptor signaling pathways. Network analysis further showed that ASE regulated protein networks related to cellular assembly, lipid metabolism, and morphogenesis, suggesting its potential for treating PD.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Phanit Songvut, Pajaree Chariyavilaskul, Phisit Khemawoot, Rossarin Tansawat
Summary: The modified formula of ECa 233 affects its disposition kinetics in the body and alters the human metabolome. After oral administration of ECa 233, accumulation of asiatic acid and an increase in choline were observed, which may be beneficial for mitigating cognitive impairment.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Farida Hayati, Lutfi Chabib, Faiza Dea Sekarraras, Wan Syarifah Faizah
Summary: This study investigated the effectiveness of SNEDDS of Pegagan Leaf Ethanol Extract (PLE) in reducing fasting blood glucose levels in zebrafish. The results showed that 100 mg/2 L SNEDDS led to a 69.90% decline in FBG levels, while 200 mg/2 L SNEDDS resulted in a 72.20% decrease.
Article
Plant Sciences
Huibiao Li, Xiaohong Chen, Jiayao Liu, Muyuan Chen, Ming Huang, Guoxin Huang, Xinlin Chen, Qin Du, Jiyan Su, Rongfeng Lin
Summary: The study found that Centella asiatica ethanol extract significantly reduced inflammation in mice with UC, alleviating symptoms of colitis and potentially serving as an effective treatment in clinical practice.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Neurosciences
Fahad Ali, Rahul, Smita Jyoti, Falaq Naz, Mo. Ashafaq, M. Shahid, Yasir Hasan Siddique
NEUROSCIENCE LETTERS
(2019)
Article
Toxicology
Yasir Hasan Siddique, Sariyah Akhtar, Rahul, Mohd. Saifullah Ansari, Barkha Shakya, Smita Jyoti, Falaq Naz
Summary: The study found that in transgenic Drosophila larvae, when combined with MMS, Luteolin resulted in a dose-dependent increase in GSH content and decrease in tissue damage and apoptosis.
Article
Toxicology
Muqtada Ali Khan, Smita Jyoti, Rahul, Falaq Naz, Gulshan Ara, Mohammad Afzal, Yasir Hasan Siddique
Summary: The study found that lemon grass extract has a protective function against MMS-induced toxicity in transgenic Drosophila larvae.
Article
Neurosciences
Falaq Naz, Rahul, Mahino Fatima, Swaleha Naseem, Wasi Khan, Amal Chandra Mondal, Yasir Hasan Siddique
Review
Neurosciences
Falaq Naz, Yasir Hasan Siddique
Summary: Neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's disease have a significant impact on quality of life, but current treatment strategies often face limitations in crossing the Blood-Brain Barrier. Nanotechnology shows promise in addressing these challenges over the past 20 years.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2021)
Article
Multidisciplinary Sciences
Rahul, Falaq Naz, Smita Jyoti, Yasir Hasan Siddique
SCIENTIFIC REPORTS
(2020)
Review
Neurosciences
Falaq Naz, Yasir Hasan Siddique
Summary: Parkinson's Disease is a prevalent, recurrent, and life-threatening neurodegenerative disease with unclear underlying mechanisms, but research methods include identifying symptoms, discovering new biological markers, and using animal models to understand pathophysiology and develop treatments.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2021)
Article
Chemistry, Medicinal
Yasir Hasan Siddique, Falaq Naz, I Mantasha, M. Shahid
Summary: The study found that Lemon-grass extract (LGE) significantly improved climbing ability and reduced oxidative stress in PD flies. Previous research identified citral as the main component of LGE, and molecular docking results supported a positive interaction between citral and human alpha-synuclein.
LETTERS IN DRUG DESIGN & DISCOVERY
(2021)
Article
Toxicology
Syed Mukhtar-Un-Nisar Andrabi, Sadaf Tamanna, Rahul, Falaq Naz, Yasir Hasan Siddique
Summary: The results of the experiment demonstrated that different concentrations of sodium hypochlorite had varying degrees of toxic effects on third instar larvae of Drosophila, causing tissue damage and DNA damage at higher concentrations, while showing no significant effects at lower concentrations.
Article
Integrative & Complementary Medicine
Yasir Hasan Siddique, Falaq Naz, Mohammad Rashid
Summary: The study on the effect of Majun Falasfa on transgenic Drosophila expressing human alpha synuclein showed that it increased lifespan, improved activity, delayed loss of cognitive abilities, reduced oxidative stress, improved antioxidant enzyme homeostasis, and decreased the formation of Lewy bodies.
CURRENT TRADITIONAL MEDICINE
(2021)
Article
Biology
Yasir Hasan Siddique, Mohd Saifullah Ansari, Rahul, Falaq Naz, Smita Jyoti, Mohammad Faisal, Sharad Pandey
Summary: This study investigated the effects of alloxan on the development and behavior of fruit flies. The results showed that alloxan could delay pupation and emergence of fruit flies, as well as decrease their locomotor activity.
JOURNAL OF BASIC AND APPLIED ZOOLOGY
(2022)
Article
Biology
Gulshan Ara, Mohammad Afzal, Falaq Naz, I Mantasha, M. Shahid, Yasir Hasan Siddique
Summary: Parkinson's Disease (PD) is a progressive neurodegenerative disorder that currently has no permanent cure. Myricetin, a common plant derived flavonoid, has been shown to delay cognitive impairments in transgenic Drosophila expressing human alpha-synuclein, possibly through a positive interaction with the protein.
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Nutrition & Dietetics
Yasir Hasan Siddique, Falaq Naz, Smita Jyoti, Fahad Ali, Rahul
JOURNAL OF DIETARY SUPPLEMENTS
(2019)
Article
Multidisciplinary Sciences
Yasir Hasan Siddique, Falaq Naz, Rahul, Mohammad Rashid, Tajuddin
Meeting Abstract
Clinical Neurology
A. Fatima, F. Naz, R. Rahul, Y. H. Siddique
PARKINSONISM & RELATED DISORDERS
(2018)
