Human Blood Concentrations of Cotinine, a Biomonitoring Marker for Tobacco Smoke, Extrapolated from Nicotine Metabolism in Rats and Humans and Physiologically Based Pharmacokinetic Modeling

Kinetics of brain nicotine accumulation in dependent and nondependent smokers assessed with PET and cigarettes containing 11C-nicotine

(2010) J. E. Rose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomonitoring of Urinary Cotinine Concentrations Associated with Plasma Levels of Nicotine Metabolites after Daily Cigarette Smoking in a Male Japanese Population

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Cytochrome P450-depedent Drug Oxidation Activity of Liver Microsomes from Microminipigs, A Possible New Animal Model for Humans in Non-clinical Studies

(2009) Norie Murayama et al.   Drug Metabolism and Pharmacokinetics

Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake

(2009) Jiang Yue et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dose-dependent Effects of Cigarette Smoke on Blood Biomarkers in Healthy Japanese Volunteers: Observations from Smoking and Non-smoking

(2009) Akiko Kume et al.   JOURNAL OF HEALTH SCIENCE

Population estimates for biomarkers of exposure to cigarette smoke in adult U.S. cigarette smokers

(2009) Hans J. Roethig et al.   NICOTINE & TOBACCO RESEARCH

Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding

(2009) C. Emoto et al.   XENOBIOTICA

Clinical Pharmacology of Nicotine: Implications for Understanding, Preventing, and Treating Tobacco Addiction

(2008) NL Benowitz   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Quantitative Prediction of CYP-mediated Drug Interaction by Physiologically Based Pharmacokinetic Modeling

(2008) Motohiro Kato et al.   PHARMACEUTICAL RESEARCH

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE

Systems Biology and Mode of Action Based Risk Assessment

(2008) Stephen W. Edwards et al.   TOXICOLOGICAL SCIENCES

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY