Hematopoietic stem cell expansion: challenges and opportunities

The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation

(2012) M. A. Walasek et al.   BLOOD

Stromal pleiotrophin regulates repopulation behavior of hematopoietic stem cells

(2011) R. Istvanffy et al.   BLOOD

Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells

(2011) A. Gerrits et al.   BLOOD

Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion

(2011) Tiago C. Luis et al.   Cell Stem Cell

Cooperation between both Wnt/ -catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion

(2011) J. M. Perry et al.   GENES & DEVELOPMENT

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

HOXA4 Induces Expansion of Hematopoietic Stem Cells In Vitro and Confers Enhancement of Pro-B-Cells In Vivo

(2011) Marilaine Fournier et al.   STEM CELLS AND DEVELOPMENT

Combination of HOXB4 and Delta-1 ligand improves expansion of cord blood cells

(2010) K. L. Watts et al.   BLOOD

Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood

(2010) C. G. Brunstein et al.   BLOOD

microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia

(2010) Yoon-Chi Han et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells

(2010) Heather A Himburg et al.   NATURE MEDICINE

Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

(2010) Colleen Delaney et al.   NATURE MEDICINE

MicroRNA miR-125b causes leukemia

(2010) M. Bousquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets

(2010) A. G. L. Ooi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

(2010) R. M. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA miR-125a controls hematopoietic stem cell number

(2010) S. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

(2010) Anthony E. Boitano et al.   SCIENCE

GSK-3β Inhibition Promotes Engraftment of Ex Vivo-Expanded Hematopoietic Stem Cells and Modulates Gene Expression

(2010) Kap-Hyoun Ko et al.   STEM CELLS

Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation

(2009) J. Hoggatt et al.   BLOOD

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL

(2009) Taito Nishino et al.   EXPERIMENTAL HEMATOLOGY

Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming

(2009) Wenlin Li et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation

(2008) C. C. Zhang et al.   BLOOD

Hematopoietic cytokines

(2008) D. Metcalf   BLOOD

Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial

(2008) M de Lima et al.   BONE MARROW TRANSPLANTATION

Valproic acid enhances the engraftability of human umbilical cord blood hematopoietic stem cells expanded under serum-free conditions*

(2008) Li-Fong Seet et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

(2008) Danwei Huangfu et al.   NATURE BIOTECHNOLOGY

Glycogen Synthase Kinase-3β Inhibition Preserves Hematopoietic Stem Cell Activity and Inhibits Leukemic Cell Growth

(2008) Tiffany Holmes et al.   STEM CELLS

Insulin-Like Growth Factor-Binding Protein 2 Secreted by a Tumorigenic Cell Line Supports Ex Vivo Expansion of Mouse Hematopoietic Stem Cells

(2008) HoangDinh Huynh et al.   STEM CELLS