Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan

Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling

(2019) Minhong Shen et al.   CANCER CELL

Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer

(2019) Jiaojie Wei et al.   Acta Pharmaceutica Sinica B

Non-Anticoagulant Heparin Prodrug Loaded Biodegradable and Injectable Thermoresponsive Hydrogels for Enhanced Anti-Metastasis Therapy

(2019) Abegaz Tizazu Andrgie et al.   MACROMOLECULAR BIOSCIENCE

Pan-cancer whole-genome analyses of metastatic solid tumours

(2019) Peter Priestley et al.   NATURE

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

(2019) Claire Vennin et al.   Nature Communications

YAP/TAZ Related BioMechano Signal Transduction and Cancer Metastasis

(2019) Bridget Martinez et al.   Frontiers in Cell and Developmental Biology

A Phase I study of the novel immunomodulatory agent PG545 (pixatimod) in subjects with advanced solid tumours

(2018) Keith Dredge et al.   BRITISH JOURNAL OF CANCER

Biomolecular analysis of matrix proteoglycans as biomarkers in non small cell lung cancer

(2018) Maristela P. Rangel et al.   GLYCOCONJUGATE JOURNAL

Phase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy

(2018) Monica Galli et al.   HAEMATOLOGICA

Heparan sulfate accumulation and perlecan/HSPG2 up-regulation in tumour tissue predict low relapse-free survival for patients with glioblastoma

(2018) Galina M. Kazanskaya et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Charting the unexplored extracellular matrix in cancer

(2018) Elysse C. Filipe et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

The biology and role of CD44 in cancer progression: therapeutic implications

(2018) Chen Chen et al.   Journal of Hematology & Oncology

Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression

(2018) Israel Vlodavsky et al.   TRENDS IN BIOCHEMICAL SCIENCES

Patient derived xenografts (PDX) predict an effective heparanase-based therapy for lung cancer

(2018) Amit Katz et al.   Oncotarget

Matrilysin/MMP-7 Cleavage of Perlecan/HSPG2 Complexed with Semaphorin 3A Supports FAK-Mediated Stromal Invasion by Prostate Cancer Cells

(2018) Brian J. Grindel et al.   Scientific Reports

Phase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy

(2018) Monica Galli et al.   HAEMATOLOGICA

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Benzoxazole derivatives: design, synthesis and biological evaluation

(2018) Saloni Kakkar et al.   Chemistry Central Journal

Specific Inhibition of Heparanase by a Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice

(2018) Ravi S. Loka et al.   ACS Applied Materials & Interfaces

Role of Extracellular Matrix in Development and Cancer Progression

(2018) Cameron Walker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Symmetrical Benzazolyl Derivatives Endowed with Potent Anti-Heparanase Activity

(2018) Antonella Messore et al.   JOURNAL OF MEDICINAL CHEMISTRY

Necuparanib, a multi-targeting heparan sulfate mimetic, targets tumor and stromal compartments in pancreatic cancer

(2018) Amanda MacDonald et al.   MOLECULAR CANCER THERAPEUTICS

Heparan Sulfate Mimetics in Cancer Therapy: The Challenge to Define Structural Determinants and the Relevance of Targets for Optimal Activity

(2018) Cinzia Lanzi et al.   MOLECULES

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

(2018) Amanpreet Kaur et al.   Cancer Discovery

Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis

(2018) Brett L. Ecker et al.   Cancer Discovery

Heparanase: A Multitasking Protein Involved in Extracellular Matrix (ECM) Remodeling and Intracellular Events

(2018) Valentina Masola et al.   Cells

Redirecting T Cells to Glypican-3 with 4-1BB Zeta Chimeric Antigen Receptors Results in Th1 Polarization and Potent Antitumor Activity

(2017) Wenpeng Li et al.   HUMAN GENE THERAPY

Force-dependent breaching of the basement membrane

(2017) Tammy T. Chang et al.   MATRIX BIOLOGY

A current view of perlecan in physiology and pathology: A mosaic of functions

(2017) Maria A. Gubbiotti et al.   MATRIX BIOLOGY

Mechanoreciprocity in cell migration

(2017) Sjoerd van Helvert et al.   NATURE CELL BIOLOGY

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis

(2017) Meera Murgai et al.   NATURE MEDICINE

Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of Necuparanib Combined with Nab‐Paclitaxel and Gemcitabine in Patients with Metastatic Pancreatic Cancer: Phase I Results

(2017) Eileen M. O'Reilly et al.   ONCOLOGIST

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

(2017) Claire Vennin et al.   Science Translational Medicine

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

(2016) Nicola Rath et al.   EMBO Molecular Medicine

Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy

(2016) Ralph D. Sanderson et al.   FEBS Journal

Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone

(2016) Sambad Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Differential immunohistochemical expression profiles of perlecan-binding growth factors in epithelial dysplasia, carcinoma in situ, and squamous cell carcinoma of the oral mucosa

(2016) Mayumi Hasegawa et al.   PATHOLOGY RESEARCH AND PRACTICE

Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease

(2016) FuiBoon Kai et al.   TRENDS IN CELL BIOLOGY

Heparanase and cancer progression: New directions, new promises

(2016) Gil Arvatz et al.   Human Vaccines & Immunotherapeutics

Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins

(2016) O Jung et al.   Oncogenesis

SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy

(2015) Anh Thu Bui et al.   CELL CYCLE

The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy

(2015) Stephen Douglass et al.   CONNECTIVE TISSUE RESEARCH

T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice

(2015) Christina Dargel et al.   GASTROENTEROLOGY

SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells

(2015) Carolina M Vicente et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer

(2015) Ruchi Malik et al.   TRENDS IN BIOTECHNOLOGY

Expression profiling of angiogenesis-related genes in brain metastases of lung cancer and melanoma

(2015) Aysegül Ilhan-Mutlu et al.   TUMOR BIOLOGY

Tissue-specificity of heparan sulfate biosynthetic machinery in cancer

(2015) Anastasia V Suhovskih et al.   Cell Adhesion & Migration

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting ECM Disrupts Cancer Progression

(2015) Freja A. Venning et al.   Frontiers in Oncology

Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts

(2015) Patricia Coutinho de Souza et al.   PLoS One

Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3

(2014) Linda Troeberg et al.   CHEMISTRY & BIOLOGY

Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma

(2014) H. Gao et al.   CLINICAL CANCER RESEARCH

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Traversing the basement membrane in vivo: A diversity of strategies

(2014) Laura C. Kelley et al.   JOURNAL OF CELL BIOLOGY

Transcriptional Activation by NFκB Increases Perlecan/HSPG2 Expression in the Desmoplastic Prostate Tumor Microenvironment

(2014) Curtis R. Warren et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Three-dimensional visualization of perlecan-rich neoplastic stroma induced concurrently with the invasion of oral squamous cell carcinoma

(2014) Satoshi Maruyama et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior

(2014) B.J. Grindel et al.   MATRIX BIOLOGY

The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling

(2014) Megan S. Lord et al.   MATRIX BIOLOGY

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular matrix assembly: a multiscale deconstruction

(2014) Janna K. Mouw et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heparan sulfate signaling in cancer

(2014) Erik H. Knelson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Assembly, heterogeneity, and breaching of the basement membranes

(2014) Alexandros Glentis et al.   Cell Adhesion & Migration

Neuroendocrine Tumors Show Altered Expression of Chondroitin Sulfate, Glypican 1, Glypican 5, and Syndecan 2 Depending on Their Differentiation Grade

(2014) Olivia García-Suárez et al.   Frontiers in Oncology

Specific genes involved in synthesis and editing of heparan sulfate proteoglycans show altered expression patterns in breast cancer

(2013) Iván Fernández-Vega et al.   BMC CANCER

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

(2013) T. R. Cox et al.   CANCER RESEARCH

Matrix detachment and proteasomal inhibitors diminish Sulf-2 expression in breast cancer cell lines and mouse xenografts

(2013) Ashwani Khurana et al.   CLINICAL & EXPERIMENTAL METASTASIS

First-in-Man Phase I Study of GC33, a Novel Recombinant Humanized Antibody Against Glypican-3, in Patients with Advanced Hepatocellular Carcinoma

(2013) A. X. Zhu et al.   CLINICAL CANCER RESEARCH

Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells

(2013) Chris D. Willis et al.   FEBS Journal

Dysfunctional endothelial cells directly stimulate cancer inflammation and metastasis

(2013) Joseph W. Franses et al.   INTERNATIONAL JOURNAL OF CANCER

Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer

(2013) P. Heldin et al.   JOURNAL OF BIOCHEMISTRY

Border patrol: Insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue borders

(2013) Mary C. Farach-Carson et al.   MATRIX BIOLOGY

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

(2012) Hua Gao et al.   CELL

Glycosaminoglycans: key players in cancer cell biology and treatment

(2012) Nikos Afratis et al.   FEBS Journal

The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling

(2012) Xin Zheng et al.   GENES CHROMOSOMES & CANCER

Parenchymal-stromal switching for extracellular matrix production on invasion of oral squamous cell carcinoma

(2012) Hamdy Metwaly et al.   HUMAN PATHOLOGY

Organ-specific Sulfation Patterns of Heparan Sulfate Generated by Extracellular Sulfatases Sulf1 and Sulf2 in Mice

(2012) Satoshi Nagamine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endorepellin Affects Angiogenesis by Antagonizing Diverse Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-evoked Signaling Pathways

(2012) Atul Goyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma

(2012) Joanna J. Phillips et al.   JOURNAL OF CLINICAL INVESTIGATION

An Introduction to Proteoglycans and Their Localization

(2012) John R. Couchman et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Heparan Sulfate Biosynthesis

(2012) Johan Kreuger et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

(2012) Min Yu et al.   NATURE

A Structural Analysis of Glycosaminoglycans from Lethal and Nonlethal Breast Cancer Tissues: Toward a Novel Class of Theragnostics for Personalized Medicine in Oncology?

(2012) Amanda Weyers et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

PG545, a Heparan Sulfate Mimetic, Reduces Heparanase Expression In Vivo, Blocks Spontaneous Metastases and Enhances Overall Survival in the 4T1 Breast Carcinoma Model

(2012) Edward Hammond et al.   PLoS One

Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy

(2012) C. P. El-Haibi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tenascin C Induces Epithelial-Mesenchymal Transition–Like Change Accompanied by SRC Activation and Focal Adhesion Kinase Phosphorylation in Human Breast Cancer Cells

(2011) Keiki Nagaharu et al.   AMERICAN JOURNAL OF PATHOLOGY

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

(2011) K Dredge et al.   BRITISH JOURNAL OF CANCER

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin

(2011) Bo Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Endorepellin, the Angiostatic Module of Perlecan, Interacts with Both the α2β1 Integrin and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)

(2011) Atul Goyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

(2011) Aya Kobayashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Stromal Endothelial Cells Directly Influence Cancer Progression

(2011) J. W. Franses et al.   Science Translational Medicine

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

High-molecular-weight hyaluronan is a novel inhibitor of pulmonary vascular leakiness

(2010) Patrick A. Singleton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Gr-1+CD11b+ Myeloid Cells Tip the Balance of Immune Protection to Tumor Promotion in the Premetastatic Lung

(2010) H. H. Yan et al.   CANCER RESEARCH

Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate

(2010) Steven D Rosen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

(2010) Achilleas D. Theocharis et al.   FEBS Journal

Proteoglycans in health and disease: the multiple roles of syndecan shedding

(2010) Tina Manon-Jensen et al.   FEBS Journal

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

(2010) Renato V. Iozzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

(2010) Hideki Kobayashi et al.   NATURE CELL BIOLOGY

Glycogene Expression Alterations Associated with Pancreatic Cancer Epithelial-Mesenchymal Transition in Complementary Model Systems

(2010) Kevin A. Maupin et al.   PLoS One

Malignant cells facilitate lung metastasis by bringing their own soil

(2010) D. G. Duda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyaluronic Acid Binding Protein 2 Is a Novel Regulator of Vascular Integrity

(2009) Nurbek Mambetsariev et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The emerging role of TGF-β superfamily coreceptors in cancer

(2009) Carmelo Bernabeu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Proteolytic interstitial cell migration: a five-step process

(2009) Peter Friedl et al.   CANCER AND METASTASIS REVIEWS

Pulmonary Vascular Destabilization in the Premetastatic Phase Facilitates Lung Metastasis

(2009) Y. Huang et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Soluble glypican 3 inhibits the growth of hepatocellular carcinomain vitroandin vivo

(2009) Sandra I. Zittermann et al.   INTERNATIONAL JOURNAL OF CANCER

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

(2009) Farideh Sabeh et al.   JOURNAL OF CELL BIOLOGY

Cell surface heparan sulfate released by heparanase promotes melanoma cell migration and angiogenesis

(2009) Madhuchhanda Roy et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Basement membrane proteoglycans: Modulators Par Excellence of cancer growth and angiogenesis

(2009) Renato V. Iozzo et al.   MOLECULES AND CELLS

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Heparanase: busy at the cell surface

(2009) Liat Fux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Anoikis: A necessary death program for anchorage-dependent cells

(2008) Paola Chiarugi et al.   BIOCHEMICAL PHARMACOLOGY

Diverse Cell Signaling Events Modulated by Perlecan†

(2008) John M. Whitelock et al.   BIOCHEMISTRY

Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway

(2008) Wei Cheng et al.   CARCINOGENESIS

The Role of Tissue Inhibitors of Metalloproteinases in Tumorigenesis and Metastasis

(2008) William Cruz-Munoz et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma

(2008) Jin-Ping Lai et al.   HEPATOLOGY

Promoter hypermethylation correlates with theHsulf-1silencing in human breast and gastric cancer

(2008) Zhao Chen et al.   INTERNATIONAL JOURNAL OF CANCER

6-O-Sulfation of Heparan Sulfate Differentially Regulates Various Fibroblast Growth Factor-dependent Signalings in Culture

(2008) Noriko Sugaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-3 Activation Triggers Extracellular Cathepsin L Release and Endorepellin Proteolysis

(2008) Jean-François Cailhier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glypican-1 modulates the angiogenic and metastatic potential of human and mouse cancer cells

(2008) Takuma Aikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies

(2008) Noriko Komatsu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Breaching the basement membrane: who, when and how?

(2008) R. Grant Rowe et al.   TRENDS IN CELL BIOLOGY

Identification of circulating endorepellin LG3 fragment: Potential use as a serological biomarker for breast cancer

(2007) Jong Wook Chang et al.   Proteomics Clinical Applications