The Role of NF-κB in Physiological Bone Development and Inflammatory Bone Diseases: Is NF-κB Inhibition “Killing Two Birds with One Stone”?

Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators?

(2019) Fulvia Ceccarelli et al.   MEDIATORS OF INFLAMMATION

Autoimmunity in 2018

(2019) Carlo Selmi   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Advances in nanomedicine for the treatment of ankylosing spondylitis

(2019) Yanhai Xi et al.   International Journal of Nanomedicine

The Pathogenesis of Ankylosing Spondylitis: an Update

(2019) Susanne Juhl Pedersen et al.   Current Rheumatology Reports

A peptide that blocks the interaction of NF-κB p65 subunit with Smad4 enhances BMP2-induced osteogenesis

(2018) Mariko Urata et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ephedra gerardiana aqueous ethanolic extract and fractions attenuate Freund Complete Adjuvant induced arthritis in Sprague Dawley rats by downregulating PGE2, COX2, IL-1β, IL-6, TNF-α, NF-kB and upregulating IL-4 and IL-10

(2018) Ambreen Malik Uttra et al.   JOURNAL OF ETHNOPHARMACOLOGY

Safety and effectiveness of iguratimod in patients with rheumatoid arthritis: Final report of a 52-week, multicenter postmarketing surveillance study

(2018) Tsuneyo Mimori et al.   Modern Rheumatology

Genetic predictors of efficacy and toxicity of iguratimod in patients with rheumatoid arthritis

(2018) Wenjing Xiao et al.   PHARMACOGENOMICS

Salvianolic Acid B Suppresses Inflammatory Mediator Levels by Downregulating NF-κB in a Rat Model of Rheumatoid Arthritis

(2018) Zeng-Bing Xia et al.   MEDICAL SCIENCE MONITOR

Novel Tumor Necrosis Factor-α (TNF-α) Inhibitors from Small Molecule Library Screening for their Therapeutic Activity Profiles against Rheumatoid Arthritis using Target-Driven Approaches and Binary QSAR Models

(2018) Mehreen Zaka et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Strategies toward rheumatoid arthritis therapy; the old and the new

(2018) Mojtaba Abbasi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A novel IkB kinase inhibitor attenuates ligature-induced periodontal disease in mice

(2018) Keitetsu Kure et al.   JOURNAL OF PERIODONTAL RESEARCH

Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems

(2017) Kazuo Okamoto et al.   PHYSIOLOGICAL REVIEWS

TNF and Bone Remodeling

(2017) Baohong Zhao   Current Osteoporosis Reports

Extracts of Bauhinia championii (Benth.) Benth. inhibit NF-B-signaling in a rat model of collagen-induced arthritis and primary synovial cells

(2016) Wei Xu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Shikonin inhibits TNF-α production through suppressing PKC-NF-κB-dependent decrease of IL-10 in rheumatoid arthritis-like cell model

(2016) Wen-Xiao Sun et al.   Journal of Natural Medicines

Bone Morphogenetic Proteins

(2016) Takenobu Katagiri et al.   Cold Spring Harbor Perspectives in Biology

Plasma n-3 fatty acids and clinical outcomes in recent-onset rheumatoid arthritis

(2015) Susanna M. Proudman et al.   BRITISH JOURNAL OF NUTRITION

Dietary extra-virgin olive oil prevents inflammatory response and cartilage matrix degradation in murine collagen-induced arthritis

(2015) María Angeles Rosillo et al.   EUROPEAN JOURNAL OF NUTRITION

Regulation of bone metabolism by Wnt signals

(2015) Yasuhiro Kobayashi et al.   JOURNAL OF BIOCHEMISTRY

Neonatal High Bone Mass With First Mutation of the NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser)RELA(Rela/p65)

(2015) Anja L Frederiksen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Nuclear Factor- B-inducing Kinase Is Expressed in Synovial Endothelial Cells in Patients with Early Arthritis and Correlates with Markers of Inflammation: A Prospective Cohort Study

(2015) K. I. Maijer et al.   JOURNAL OF RHEUMATOLOGY

Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-κB

(2015) Hong Ki Min et al.   PLoS One

RANKL/OPG; Critical role in bone physiology

(2015) T. John Martin et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model

(2015) Caroline Morin et al.   ARTHRITIS RESEARCH & THERAPY

Efficacy of TNFα blockers in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a meta-analysis

(2014) Johanna Callhoff et al.   ANNALS OF THE RHEUMATIC DISEASES

RelB-induced Expression of Cot, an MAP3K Family Member, Rescues RANKL-induced Osteoclastogenesis in Alymphoplasia Mice by Promoting NF-κB2 Processing by IKKα

(2014) Rei Taniguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB

(2014) Hengwei Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis

(2014) Ae R Noort et al.   JOURNAL OF PATHOLOGY

Inhibition of BMP2-Induced Bone Formation by the p65 Subunit of NF-κB via an Interaction With Smad4

(2014) Shizu Hirata-Tsuchiya et al.   MOLECULAR ENDOCRINOLOGY

Regulation of NF-κB by TNF family cytokines

(2014) Matthew S. Hayden et al.   SEMINARS IN IMMUNOLOGY

Periodontal Disease: Linking the Primary Inflammation to Bone Loss

(2013) Adriana Di Benedetto et al.   Clinical & Developmental Immunology

NF-κB RelB Negatively Regulates Osteoblast Differentiation and Bone Formation

(2013) Zhenqiang Yao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The suppressive effects of Saposhnikovia divaricata (Fangfeng) chromone extract on rheumatoid arthritis via inhibition of nuclear factor-κB and mitogen activated proteinkinases activation on collagen-induced arthritis model

(2013) Xiangying Kong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Osteoclasts: New Insights

(2013) Feng Xu et al.   Bone Research

Bone Remodeling and Energy Metabolism: New Perspectives

(2013) Francisco J. A. de Paula et al.   Bone Research

Accumulation of p100, a Precursor of NF-κB2, Enhances Osteoblastic Differentiationin Vitroand Bone Formationin Vivoinaly/alyMice

(2012) Yoshinori Seo et al.   MOLECULAR ENDOCRINOLOGY

Estrogen Deficiency Induces the Differentiation of IL-17 Secreting Th17 Cells: A New Candidate in the Pathogenesis of Osteoporosis

(2012) Abdul M. Tyagi et al.   PLoS One

Activated NF-κB in Bone Marrow Mesenchymal Stem Cells from Systemic Lupus Erythematosus Patients Inhibits Osteogenic Differentiation Through Downregulating Smad Signaling

(2012) Yu Tang et al.   STEM CELLS AND DEVELOPMENT

New insights into osteoclastogenic signaling mechanisms

(2012) Tomoki Nakashima et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A mixture of Trachelospermi caulis and Moutan cortex radicis extracts suppresses collagen-induced arthritis in mice by inhibiting NF-κB and AP-1

(2011) Hyuk Soon Kim et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation

(2011) Masayoshi Yamaguchi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Suppression of NF-κB Increases Bone Formation and Ameliorates Osteopenia in Ovariectomized Mice

(2010) Neil Alles et al.   ENDOCRINOLOGY

Inhibition of Inflammatory Cytokine Production from Rheumatoid Synovial Fibroblasts by a Novel I B Kinase Inhibitor

(2010) A. Tsuchiya et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NIK Stabilization in Osteoclasts Results in Osteoporosis and Enhanced Inflammatory Osteolysis

(2010) Chang Yang et al.   PLoS One

Tumor Necrosis Factor α Represses Bone Morphogenetic Protein (BMP) Signaling by Interfering with the DNA Binding of Smads through the Activation of NF-κB

(2009) Masato Yamazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processing of the NF-κB2 Precursor, p100, to p52 is Critical for RANKL-Induced Osteoclast Differentiation

(2009) Toshimasa Maruyama et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Pivotal Role of the Alternative NF-κB Pathway in Maintenance of Basal Bone Homeostasis and Osteoclastogenesis

(2009) Niroshani S Soysa et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Periodic, Partial Inhibition of I B Kinase  -Mediated Signaling Yields Therapeutic Benefit in Preclinical Models of Rheumatoid Arthritis

(2009) K. M. Gillooly et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Notch and the Skeleton

(2009) S. Zanotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of osteoblastic bone formation by nuclear factor-κB

(2009) Jia Chang et al.   NATURE MEDICINE

Defective Osteoclastogenesis by IKKβ-null Precursors Is a Result of Receptor Activator of NF-κB Ligand (RANKL)-induced JNK-dependent Apoptosis and Impaired Differentiation

(2008) Jesse E. Otero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice

(2008) Sergio Vaira et al.   JOURNAL OF CLINICAL INVESTIGATION

RelB is the NF- B subunit downstream of NIK responsible for osteoclast differentiation

(2008) S. Vaira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro selection of optimal RelB/p52 DNA-binding motifs

(2007) Liudmila V. Britanova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS