Article
Endocrinology & Metabolism
Wenxin He, Xiankun Cao, Keyu Kong, Kewei Rong, Shuai Han, An Qin
Summary: Ceritinib is beneficial in preventing bone loss by suppressing osteoclastic Akt and nuclear factor kappa B (NF-kappa B) signaling.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
LuLu Qian, Jun-Zhao Li, XueMei Sun, Jie-Bin Chen, Ying Dai, Qiu-Xiang Huang, Ying-Ji Jin, Qing-Ning Duan
Summary: The study demonstrates that safinamide can inhibit the production of pro-inflammatory cytokines by macrophages, reduce the release of inflammatory mediators, prevent leukocyte migration, and decrease the generation of related enzymes. These effects are mainly achieved through safinamide's inhibition of the TLR4/NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Ali S. Alshehri, Attalla F. El-kott, Mohamed S. A. El-Gerbed, Ayman E. El-Kenawy, Ghadeer M. Albadrani, Heba S. Khalifa
Summary: The study evaluated the protective effect of kaempferol against cadmium chloride-induced liver damage through antioxidant and anti-inflammatory mechanisms, involving the upregulation of Nr12/HO-1 axis and suppression of NF-kappa B p65 and keap1.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Immunology
Lea S. S. Lentz, Annika J. J. Stutz, Nicole Meyer, Kristin Schubert, Isabel Karkossa, Martin von Bergen, Ana C. C. Zenclussen, Anne Schumacher
Summary: Maintaining a balance between proinflammatory and anti-inflammatory immune responses is crucial for maternal tolerance of the fetus during pregnancy. This study found that fetal tissue-derived factor human chorionic gonadotropin (hCG) can increase the frequency of regulatory T cells (Tregs), inhibit the differentiation of proinflammatory Th17 cells, and mitigate the negative effects of proinflammatory Th17 cells on pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Tingting Fan, Yanli Xie, Shumin Sun
Summary: The study revealed that anthocyanin C3G and its metabolites PCA and PGA have an impact on the binding of AFB(1) and HSA, interfering with their interaction and reducing the transport of AFB(1).
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2021)
Article
Biochemistry & Molecular Biology
Hai-Jian Sun, Si-Ping Xiong, Xu Cao, Lei Cao, Meng-Yuan Zhu, Zhi-Yuan Wu, Jin-Song Bian
Summary: Sodium tetrasulfide (Na2S4) treatment can ameliorate diabetic kidney disease by inhibiting inflammation cytokines and reducing oxidative stress, renal fibrosis, and cell apoptosis. Na2S4 acts through sulfhydrating SIRT1 to deactivate p65 NF-kappa B and STAT3 phosphorylation/acetylation, ultimately reducing oxidative stress, inflammation response, and EMT progression in renal tubular epithelial cells.
Article
Integrative & Complementary Medicine
Zhenfeng Liu, Wuming Zhou, Qingyang Liu, Zhirong Huan, Qiubo Wang, Xin Ge
Summary: The study found that Pachymic acid (PA) extracted from Poria cocos can effectively protect the heart from damage caused by hemorrhagic shock (HS). PA exerts its effects by inhibiting the NF-kappa B pathway, reducing inflammation and cardiac cell apoptosis, and improving cardiac function and structure.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Qiu-Ju Han, Yong-Liang Mu, Hua-Jun Zhao, Rong-Rong Zhao, Quan-Juan Guo, Yu-Hang Su, Jian Zhang
Summary: Fasudil effectively protects against TAA-induced liver injury by decreasing collagen deposition and inhibiting the activation of hepatic stellate cells. Additionally, it activates NK cells both in vivo and in vitro, providing a potential therapeutic strategy for liver fibrosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Rosa Andres-Ejarque, Hira Bahadur Ale, Katarzyna Grys, Isabella Tosi, Shane Solanky, Chrysanthi Ainali, Zeynep Catak, Hemawtee Sreeneebus, Jake Saklatvala, Nick Dand, Emanuele de Rinaldis, Anna Chapman, Frank O. Nestle, Michael R. Barnes, Richard B. Warren, Nick J. Reynolds, Christopher E. M. Griffiths, Jonathan N. Barker, Catherine H. Smith, Paola Di Meglio
Summary: By conducting in-depth immunomonitoring of blood immune cells in patients with psoriasis, researchers have identified phosphorylation of NF kappa Bp65 in cDC2 before therapy as an indication of non-response to the anti-TNF therapy adalimumab.
NATURE COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Jingyan Guan, Yibao Li, Feng Lu, Jingwei Feng
Summary: Adipose-derived stem cells (ADSCs) ameliorate ovalbumin-induced atopic dermatitis (AD) in mice mainly by downregulating IL-17 secretion of Th17 cells.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Hiroshi Tawarayama, Kota Umeki, Maki Inoue-Yanagimachi, Naoki Takahashi, Hirokazu Hasegawa, Noriko Himori, Satoru Tsuda, Hiroshi Kunikata, Takaaki Akaike, Toru Nakazawa
Summary: We investigated the impact of GSSSG on LPS-induced inflammation in retinal glia. The results showed that GSSSG inhibited inflammatory responses and reduced cell death. Additionally, GSSSG inhibited the NF-κB signaling pathway by suppressing the activation of TAK1. Finally, GSSSG has the potential to prevent inflammation-associated ocular diseases by inhibiting proinflammatory cytokine expression in retinal glial cells.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Haiyun Chen, Jing Zhong, Jianxuan Li, Zhiwei Zeng, Qian Yu, Chunyan Yan
Summary: PTP70-2 demonstrates potential anti-inflammatory effects and neuroprotective activity in LPS-damaged BV2 microglial cells and neuroinflammation-injured primary cortical neurons. It reduces the expression of inflammatory cytokines, down-regulates TLR4-, MyD88-, and NF-kappa B-related proteins, and prevents neuroinflammation-induced neurotoxicity by mitigating ROS overproduction and MMP dissipation. These effects are related to the modulation of the TLR4-mediated MyD88/NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cell Biology
Yongqiang Chen, Spencer B. Gibson
Summary: This study identifies TSSC4 as a novel tumor suppressor and autophagy inhibitor that plays a crucial role in inhibiting GBM cell growth and enhancing sensitivity to TMZ treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Natchanok Talapphet, Subramanian Palanisamy, ChangSheng Li, Nan Ma, Narayanasamy Marimuthu Prabhu, SangGuan You
Summary: The polysaccharides extracted from Taraxacum platycarpum showed significant immunostimulatory activity on murine macrophage cells by activating MAPK and NF-κB pathways through TLR4, TLR2, and CR3 receptors. The protein content of the polysaccharides played a crucial role in activating RAW264.7 cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Changwei Jing, Jiaxing Niu, Yang Liu, Ning Jiao, Libo Huang, Shuzhen Jiang, Lei Yan, Weiren Yang, Yang Li
Summary: The study aimed to investigate the effects of adding tannic acid (TA) extracted from Galla chinensis to the diet of broiler chickens on intestinal development. Results showed that supplementation with 300 mg/kg microencapsulated TA improved intestinal development in broiler chickens by suppressing inflammatory responses through NF-kappa B blockage. These findings support the potential use of TA sourced from Galla chinensis in the poultry industry.
Article
Rheumatology
Hong Ki Min, Hae-Rim Kim, Sang-Heon Lee, Yeon Sik Hong, Moon-Young Kim, Sung-Hwan Park, Kwi Young Kang
Summary: This study compares the drug retention times and clinical efficacy of alternative TNFi and secukinumab in ankylosing spondylitis patients. The results show that alternative TNFi has better drug retention and clinical efficacy in secondary non-responders.
MODERN RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Hong Ki Min, JeongWon Choi, Seon-Yeong Lee, A. Ram Lee, Byung-Moo Min, Mi-La Cho, Sung-Hwan Park
Summary: VnP-16 plus celecoxib prevented the progression of SpA in a mouse model by regulating Th17/Treg imbalance and suppressing the expression of proinflammatory cytokines.
Article
Rheumatology
Hong Ki Min, Se Hee Kim, Kyung-Ann Lee, Joon-Hyung Jo, Young So, Hyun Woo Chung, Sang-Heon Lee, Hae-Rim Kim
Summary: This study compared the findings of salivary gland ultrasonography (SGUS) and salivary gland scintigraphy (SGS) in patients with primary SS. The study found that patients with a higher SGUS score had lower salivary gland function, and there was a significant correlation between SGUS score and SGS results. These findings suggest a possible predictive role of SGUS in diagnosing salivary gland dysfunction.
Article
Multidisciplinary Sciences
JunSoo Ro, Se Hee Kim, Hae-Rim Kim, Sang-Heon Lee, Hong Ki Min
Summary: The study utilized Korean NHIS data to analyze the impact of lifestyle and comorbidities on seropositive RA occurrence, finding that high-intensity regular physical exercise and moderate alcohol consumption are negatively associated with seropositive RA occurrence.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Junbeom Lee, Hong Ki Min, Cho Yeon Park, Hyun Ki Kang, Sung Youn Jung, Byung-Moo Min
Summary: The study shows that VnP-16 can prevent and treat periodontitis by regulating bone remodeling, immune response, and inflammatory reactions.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Multidisciplinary Sciences
Dayoung Kim, Jeeyoung Oh, Hong Ki Min, Hae-Rim Kim, Kyomin Choi
Summary: This cross-sectional study retrospectively analyzed the outcomes of nailfold capillaroscopy (NFC) and clinical characteristics in patients and asymptomatic carriers with transthyretin (TTR) gene mutation. The study found that all participants showed microvascular abnormalities in NFC, highlighting the importance of early identification of carriers who may progress to symptomatic patients.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Hong Ki Min, Se Hee Kim, Ji-Yeon Lee, Sang-Heon Lee, Hae-Rim Kim
Summary: In this study, the effect of DJ-1 on helper T cell differentiation, fibroblast-like synoviocyte (FLS) activation, and osteoclastogenesis in rheumatoid arthritis was investigated. The results demonstrated that DJ-1 inhibits the production of pro-inflammatory cytokines and activation of RA-FLS, as well as osteoclast formation. Therefore, DJ-1 holds potential importance in the treatment of rheumatoid arthritis.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Hong Ki Min, Hae-Rim Kim, Sang-Heon Lee, Kwi Young Kang, Sung-Hwan Park, Seung-Ki Kwok
Summary: The study evaluated the predictive role of time-averaged DAS28 and HAQ on CVD events in patients with RA. The results showed that high time-averaged DAS28 was significantly associated with CVD incidence and had a higher cumulative risk of CVD.
Article
Multidisciplinary Sciences
SeungCheon Yang, Hong Ki Min, Jin-Sil Park, Hyun Sik Na, Mi-La Cho, Sung-Hwan Park
Summary: Green-lipped mussel has chondro-modulatory and anti-inflammatory properties that can reduce arthritis severity and inhibit osteoclast differentiation.
Article
Multidisciplinary Sciences
Hong Ki Min, Se Hee Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: The CT syndesmophyte score (CTSS) can evaluate spinal progression more accurately than mSASSS in ankylosing spondylitis (AS), but it is complex and time consuming. Therefore, a simplified CTSS (sCTSS) method is proposed for measuring spinal structural changes in AS. The results show that sCTSS and CTSS have similar detection rates in evaluating spinal structural damage and progression.
SCIENTIFIC REPORTS
(2023)
Article
Rheumatology
Hong Ki Min, Se Hee Kim, Ji-Yeon Won, Kyoung-Woon Kim, Ji-Yeon Lee, Sang-Heon Lee, Hae-Rim Kim
Summary: This study aimed to evaluate the preventive role of the tyrosine kinase inhibitor dasatinib in a rheumatoid arthritis (RA) animal model. The results showed that dasatinib pretreatment reduced the clinical arthritis histological scores and downregulated Fc epsilon R1(+) cells while upregulating regulatory T cells. In vitro dasatinib treatment also decreased IL-17(+) CD4(+) T-cell differentiation and increased CD4(+) CD24(high) Foxp3(+) T-cell differentiation. Additionally, dasatinib-pretreated mice had lower numbers of TRAP(+) osteoclasts and smaller resorption areas. These findings indicate that dasatinib protects against arthritis by regulating T cells and inhibiting osteoclastogenesis, suggesting its therapeutic potential in early RA treatment.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Physics, Multidisciplinary
Jeonghyeon Suh, Sanghyun Park, Hongki Min
Summary: Understanding the transport behavior of an electronic system under the influence of a magnetic field is crucial in condensed matter physics, especially in topological materials. The study focuses on the Boltzmann magnetotransport theory in topological materials with a nonvanishing Berry curvature, taking into account both the field-driven anisotropy and inherent anisotropy in the band dispersion. The results reveal the integral equation for the effective mean-free-path vector, considering the coupling between the magnetic field, Berry curvature, and mobility, and show the induced anisotropy in the relaxation time in Weyl semimetals.
NEW JOURNAL OF PHYSICS
(2023)
Article
Multidisciplinary Sciences
Hong Ki Min, Se Hee Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: This study evaluated the predictive role of baseline radiographic change and disease activity on drug retention and clinical response in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor inhibitor (TNFi). The study found that the presence of erosions and high time-averaged disease activity were associated with poor retention of TNFi by RA patients, while higher baseline disease activity score was associated with reduced clinical response in patients with RA.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
H. K. Min, H. -r. Kim, S. -h. Lee, K. Y. Kang, S. -h. Park, K. Shin, J. Kim, S. -k. Kwok
Summary: Patients with ankylosing spondylitis (AS) exhibit heterogeneity in disease course and treatment response. Cluster-based phenotypes can help predict AS disease course. In this study, drug retention was lower in cluster B patients compared to cluster A, but clinical efficacy was comparable between the two groups at the 1-year follow-up, providing valuable insights for predicting drug retention and clinical efficacy in AS patients.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Hong Ki Min, Hae-Rim Kim, Sang-Heon Lee, Sojeong Park, Minae Park, Yeon Sik Hong, Moon-Young Kim, Sung-Hwan Park, Kwi Young Kang
Summary: Compared with the general population, patients with radiographic axial spondyloarthritis have a higher risk of aortic regurgitation and atrial fibrillation, but not AV block II-III.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)