Neat1 is a p53-inducible lincRNA essential for transformation suppression

Long Noncoding RNAs in Cancer Pathways

(2016) Adam M. Schmitt et al.   CANCER CELL

An inducible long noncoding RNA amplifies DNA damage signaling

(2016) Adam M Schmitt et al.   NATURE GENETICS

p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

(2016) Carmen Adriaens et al.   NATURE MEDICINE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

(2016) Esther Castellano et al.   Nature Communications

Aberrant NEAT1 expression is associated with clinical outcome in high grade glioma patients

(2015) Chengbiao He et al.   APMIS

Frequent involvement of chromatin remodeler alterations in gastric field cancerization

(2015) Hideyuki Takeshima et al.   CANCER LETTERS

Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation

(2015) Nilotpal Roy et al.   GENES & DEVELOPMENT

p53-dependent non-coding RNA networks in chronic lymphocytic leukemia

(2015) C J Blume et al.   LEUKEMIA

Melanoma cells influence the differentiation pattern of human epidermal keratinocytes

(2015) Ondřej Kodet et al.   Molecular Cancer

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage

(2015) Scott T. Younger et al.   NUCLEIC ACIDS RESEARCH

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

(2015) Nicolas Léveillé et al.   Nature Communications

NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer

(2015) Yunlong Li et al.   Oncotarget

Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition

(2014) Gaofeng Xiong et al.   BMC CANCER

Axon Guidance Factor SLIT2 Inhibits Neural Invasion and Metastasis in Pancreatic Cancer

(2014) A. Gohrig et al.   CANCER RESEARCH

The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice

(2014) S. Nakagawa et al.   DEVELOPMENT

A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression

(2014) N. Okada et al.   GENES & DEVELOPMENT

The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites

(2014) Jason A. West et al.   MOLECULAR CELL

The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma

(2014) Guido von Figura et al.   NATURE CELL BIOLOGY

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

(2014) H Choudhry et al.   ONCOGENE

The long noncoding RNA Neat1 is required for mammary gland development and lactation

(2014) Laura Standaert et al.   RNA

The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer

(2014) Dimple Chakravarty et al.   Nature Communications

Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature

(2014) Yolanda Sánchez et al.   Nature Communications

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Gene Regulatory Networks Governing Pancreas Development

(2013) H. Efsun Arda et al.   DEVELOPMENTAL CELL

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies

(2013) Tetsuro Hirose et al.   MOLECULAR BIOLOGY OF THE CELL

LncRNA loc285194 is a p53-regulated tumor suppressor

(2013) Qian Liu et al.   NUCLEIC ACIDS RESEARCH

Frameshift mutations of axon guidance genes ROBO1 and ROBO2 in gastric and colorectal cancers with microsatellite instability

(2013) Eun Mi Je et al.   PATHOLOGY

OpenCFU, a New Free and Open-Source Software to Count Cell Colonies and Other Circular Objects

(2013) Quentin Geissmann   PLoS One

Paraspeckle formation during the biogenesis of long non-coding RNAs

(2013) Takao Naganuma et al.   RNA Biology

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

(2013) Liz J. Valente et al.   Cell Reports

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

SWI/SNF gene variants and glioma risk and outcome

(2012) Ernest K. Amankwah et al.   Cancer Epidemiology

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Distinct p53 genomic binding patterns in normal and cancer-derived human cells

(2012) Krassimira Botcheva et al.   CELL CYCLE

Induced Mist1 Expression Promotes Remodeling of Mouse Pancreatic Acinar Cells

(2012) Daniel Direnzo et al.   GASTROENTEROLOGY

Gata6is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice

(2012) Paola Martinelli et al.   GUT

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

A tumor suppressor role for srGAP3 in mammary epithelial cells

(2012) A Lahoz et al.   ONCOGENE

Evaluation of SOX9 Expression in Pancreatic Ductal Adenocarcinoma and Intraductal Papillary Mucinous Neoplasm

(2012) Takayuki Tanaka et al.   PANCREAS

The RB family is required for the self-renewal and survival of human embryonic stem cells

(2012) Jamie F. Conklin et al.   Nature Communications

Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling

(2011) B. Kigel et al.   BLOOD

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

(2011) Carmen Guerra et al.   CANCER CELL

Overexpression of Notch ligand Dll1 in B16 melanoma cells leads to reduced tumor growth due to attenuated vascularization

(2011) Jian-Ping Zhang et al.   CANCER LETTERS

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice

(2011) Shinichi Nakagawa et al.   JOURNAL OF CELL BIOLOGY

miR-34 miRNAs provide a barrier for somatic cell reprogramming

(2011) Yong Jin Choi et al.   NATURE CELL BIOLOGY

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

(2011) Tiffany Hung et al.   NATURE GENETICS

Cystic precursors to invasive pancreatic cancer

(2011) Hanno Matthaei et al.   Nature Reviews Gastroenterology & Hepatology

Human Cancer Long Non-Coding RNA Transcriptomes

(2011) Ewan A. Gibb et al.   PLoS One

Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease

(2010) Anthony C Vernon et al.   BMC NEUROSCIENCE

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

p53 at a glance

(2010) C. A. Brady et al.   JOURNAL OF CELL SCIENCE

β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

(2010) John P. Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Paraspeckles

(2010) A. H. Fox et al.   Cold Spring Harbor Perspectives in Biology

Hijacking the Chromatin Remodeling Machinery: Impact of SWI/SNF Perturbations in Cancer

(2009) B. Weissman et al.   CANCER RESEARCH

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Loss of the Acinar-Restricted Transcription Factor Mist1 Accelerates Kras-Induced Pancreatic Intraepithelial Neoplasia

(2009) Guanglu Shi et al.   GASTROENTEROLOGY

Molecular profiling of the “plexinome” in melanoma and pancreatic cancer

(2009) Asha Balakrishnan et al.   HUMAN MUTATION

An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles

(2009) Christine M. Clemson et al.   MOLECULAR CELL

Altered Nuclear Retention of mRNAs Containing Inverted Repeats in Human Embryonic Stem Cells: Functional Role of a Nuclear Noncoding RNA

(2009) Ling-Ling Chen et al.   MOLECULAR CELL

The promises and perils of p53

(2009) Valery Krizhanovsky et al.   NATURE

MENε/β noncoding RNAs are essential for structural integrity of nuclear paraspeckles

(2009) Yasnory T. F. Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

MEN  /  nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles

(2008) H. Sunwoo et al.   GENOME RESEARCH