GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability

BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation

(2017) Mayu Isono et al.   Cell Reports

DNA damage response regulation by microRNAs as a therapeutic target in cancer

(2016) Maryam Majidinia et al.   DNA REPAIR

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

(2016) Panagiotis Galanos et al.   NATURE CELL BIOLOGY

An inducible long noncoding RNA amplifies DNA damage signaling

(2016) Adam M Schmitt et al.   NATURE GENETICS

MicroRNA-23a downregulates the expression of interferon regulatory factor-1 in hepatocellular carcinoma cells

(2016) Yihe Yan et al.   ONCOLOGY REPORTS

Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events

(2016) Arghavan Ashouri et al.   Nature Communications

Targeting DNA Repair in Cancer: Beyond PARP Inhibitors

(2016) Jessica S. Brown et al.   Cancer Discovery

Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression

(2015) Zhenhua Luo et al.   AGING CELL

RIP1 Kinase Is an Oncogenic Driver in Melanoma

(2015) X. Y. Liu et al.   CANCER RESEARCH

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres

(2015) S. Badie et al.   EMBO JOURNAL

A BRCA1-interacting lncRNA regulates homologous recombination

(2015) V. Sharma et al.   EMBO REPORTS

p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Integrated Pulsed Stable Isotope Labeling With Amino Acids in Cell Culture (pSILAC) and Next Generation Sequencing (NGS) Analyses

(2015) Sabine Hünten et al.   MOLECULAR & CELLULAR PROTEOMICS

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

(2015) Nicolas Léveillé et al.   Nature Communications

Digital Quantitation of Potential Therapeutic Target RNAs

(2015) David W. Dodd et al.   Nucleic Acid Therapeutics

Are common fragile sites merely structural domains or highly organized “functional” units susceptible to oncogenic stress?

(2014) Alexandros G. Georgakilas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression

(2014) N. Okada et al.   GENES & DEVELOPMENT

Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53-binding sites

(2014) Masashi Idogawa et al.   HUMAN MOLECULAR GENETICS

The multilayered complexity of ceRNA crosstalk and competition

(2014) Yvonne Tay et al.   NATURE

ColonyArea: An ImageJ Plugin to Automatically Quantify Colony Formation in Clonogenic Assays

(2014) Camilo Guzmán et al.   PLoS One

Novel method for the high-throughput processing of slides for the comet assay

(2014) Mahsa Karbaschi et al.   Scientific Reports

Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation

(2014) Reena V. Kartha et al.   Frontiers in Genetics

BRCA1-Ku80 Protein Interaction Enhances End-joining Fidelity of Chromosomal Double-strand Breaks in the G1Phase of the Cell Cycle

(2013) Guochun Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression

(2013) W Wang et al.   Cell Death & Disease

1p36 Tumor Suppression--A Matter of Dosage?

(2012) K.-O. Henrich et al.   CANCER RESEARCH

Signalling the end of the line

(2012) John van Tuyn et al.   NATURE CELL BIOLOGY

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

miR-34a functions as a tumor suppressor modulating EGFR in glioblastoma multiforme

(2012) D Yin et al.   ONCOGENE

The quantitative proteome of a human cell line

(2011) M. Beck et al.   Molecular Systems Biology

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest

(2011) Zhihui Feng et al.   NUCLEIC ACIDS RESEARCH

Characterization of the DNA binding specificity of Shelterin complexes

(2011) Kyung H. Choi et al.   NUCLEIC ACIDS RESEARCH

Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress

(2011) L Dong et al.   ONCOGENE

MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma

(2011) L. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic changes of DNA repair genes in cancer

(2011) C. Lahtz et al.   Journal of Molecular Cell Biology

Role of shelterin in cancer and aging

(2010) Paula Martínez et al.   AGING CELL

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors

(2010) Teresa Tapia et al.   Epigenetics

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

(2010) M William Audeh et al.   LANCET

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

A common gain of function of p53 cancer mutants in inducing genetic instability

(2009) D P Liu et al.   ONCOGENE

Nuclear DNA Damage as a Direct Cause of Aging

(2009) Benjamin P. Best   REJUVENATION RESEARCH

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Novel genetic variants in microRNA genes and familial breast cancer

(2008) Jie Shen et al.   INTERNATIONAL JOURNAL OF CANCER

The telosome/shelterin complex and its functions

(2008) Huawei Xin et al.   GENOME BIOLOGY