Article
Biology
Kyung Eun Lee, Jeong Hoon Cho, Hyun-Ok Song
Summary: C. elegans dauer is a reversible developmental arrest induced by adverse environmental cues. The study found that calumenin plays a crucial role in dauer formation and may be involved in signaling pathways that regulate dauer formation.
Article
Genetics & Heredity
Biao Hu, Tianju Liu, Zhe Wu, Sem H. Phan, Karen Blyth
Summary: P53 can suppress the transcription and translation of C/EBP beta gene, and regulate the translation of LAP and LIP isoforms of C/EBP beta through the expression of eIF4E and eIF4E-BP1; furthermore, the 5'UTR region plays an important role in the differential control of LAP and LIP translation of C/EBP beta.
Article
Biochemistry & Molecular Biology
JanWillem Duitman, Leonie Hartl, Joris J. T. H. Roelofs, Maarten F. Bijlsma, C. Arnold Spek
Summary: C/EBP delta is downregulated in pancreatic ductal adenocarcinoma (PDAC) cells and associated with decreased patient survival and pro-tumorigenic properties. Systemic C/EBP delta facilitates pancreatic cancer metastasis, potentially through C/EBP delta-PAFR-dependent tumor cell extravasation.
Article
Biochemistry & Molecular Biology
HaiXu Song, Jiahao Liu, Xiaoxiang Tian, Dan Liu, Jiayin Li, Xiaojie Zhao, Zhu Mei, Chenghui Yan, Yaling Han
Summary: The transcription factor CCAAT/enhancer-binding protein ? (C/EBP?) plays a crucial role in the differentiation and cell cycle control of megakaryocytes (MKs), potentially aiding in the treatment of thrombocytopenia and other platelet-related disorders.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Bing Huang, Weihao Zhao, Xue Cai, Yumin Zhu, Yingxian Lu, Junli Zhao, Nan Xiang, Xiaofei Wang, Hu Deng, Xiaping Tang, Lingyu Liu, Yanyu Zhao, Yigong Shi
Summary: The harmful effects of leaked electromagnetic radiation (EMR) on human health, particularly on oligodendrocytes, have raised concerns due to the rapid growth of wireless electronic devices. Through experiments, it was found that pulse-modulated EMR significantly increased the mRNA level of C/EBP beta in oligodendrocytes and altered the expression and functions of its related genes and proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rashmi Chandra, Fatima Farah, Fernando Munoz-Lobato, Anirudh Bokka, Kelli L. Benedetti, Chantal Brueggemann, Mashel Fatema A. Saifuddin, Julia M. Miller, Joy Li, Eric Chang, Aruna Varshney, Vanessa Jimenez, Anjana Baradwaj, Cibelle Nassif, Sara Alladin, Kristine Andersen, Angel J. Garcia, Veronica Bi, Sarah K. Nordquist, Raymond L. Dunn, Vanessa Garcia, Kateryna Tokalenko, Emily Soohoo, Fabiola Briseno, Sukhdeep Kaur, Malcolm Harris, Hazel Guillen, Decklin Byrd, Brandon Fung, Andrew E. Bykov, Emma Odisho, Bryan Tsujimoto, Alan Tran, Alex Duong, Kevin C. Daigle, Rebekka Paisner, Carlos E. Zuazo, Christine Lin, Aarati Asundi, Matthew A. Churgin, Christopher Fang-Yen, Martina Bremer, Saul Kato, Miri K. VanHoven, Noelle D. L'Etoile
Summary: Animals with complex nervous systems require sleep for memory consolidation and synaptic remodeling. In this study, the researchers show that even in a small nervous system like the Caenorhabditis elegans, sleep is necessary for these processes. It is also unclear whether sleep collaborates with experience to alter specific synaptic connections and affect behavior.
Article
Cell & Tissue Engineering
Neena Lala-Tabbert, Hamood AlSudais, Francois Marchildon, Dechen Fu, Nadine Wiper-Bergeron
Summary: The study shows that the transcription factor C/EBP beta is necessary to maintain quiescence of satellite cells in uninjured muscle. Loss of C/EBP beta in satellite cells promotes premature exit from quiescence, while forced expression of C/EBP beta inhibits proliferation by upregulating quiescence-associated genes. Additionally, caveolin-1 is identified as a direct transcriptional target of C/EBP beta required for cell cycle exit in muscle satellite cells expressing C/EBP beta.
Article
Biochemistry & Molecular Biology
Juliane C. Campos, Ziyun Wu, Paige D. Rudich, Sonja K. Soo, Meeta Mistry, Julio C. b Ferreira, T. Keith Blackwell, Jeremy M. Van Raamsdonk
Summary: Disrupting subunits of the mitochondrial electron transport chain results in the upregulation of genes involved in innate immunity, which promotes increased resistance to bacterial pathogens and extended longevity in long-lived mitochondrial mutants. Both the p38-mediated innate immune signaling pathway and the mitoUPR act together on the same innate immunity genes to modulate lifespan.
Article
Biochemistry & Molecular Biology
Qin Xia, Jose C. Casas-Martinez, Eduardo Zarzuela, Javier Munoz, Antonio Miranda-Vizuete, Katarzyna Goljanek-Whysall, Brian McDonagh
Summary: Exercise increases Reactive Oxygen Species (ROS) in muscle, promoting changes in gene transcription and mitochondrial biogenesis. Peroxiredoxin 2 (Prdx2) is necessary for the adaptive response to physiological levels of H2O2 and exercise. H2O2 improves mitochondrial capacity and myogenesis in myoblasts, which is suppressed when Prdxs expression is decreased. Swimming exercise in C. elegans enhances mitochondrial content, fitness, survival, and longevity, but these benefits are diminished in prdx-2 mutant worms. Prdx-2 plays a key regulatory role in the redox signalling cascade following endogenous ROS generation.
Article
Biology
Romane Leboutet, Celine Largeau, Leonie Mueller, Magali Prigent, Gregoire Quinet, Manuel S. Rodriguez, Marie-Helene Cuif, Thorsten Hoppe, Emmanuel Culetto, Christophe Lefebvre, Renaud Legouis, Hong Zhang
Summary: The proteins Atg8/LC3/GABARAP are crucial for various steps of autophagy, including initiation, cargo recognition and engulfment, vesicle closure and degradation. In C. elegans, the single homologs of LC3 and GABARAP, LGG-1 and LGG-2, play similar roles. Through mutagenesis experiments, we discovered that LGG-1 is essential for autophagy and development in C. elegans, but its functions can be fully achieved without its localization to the membrane.
Article
Physiology
Pengyuan Chen, Wanzi Hong, Ziying Chen, Flora Gordillo-Martinez, Siying Wang, Hualin Fan, Yuanhui Liu, Yining Dai, Bo Wang, Lei Jiang, Hongjiao Yu, PengCheng He
Summary: The transcription factor C/EBP alpha plays a crucial role in the osteochondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and vascular calcification. C/EBP alpha regulates the expression of the osteochondrogenic gene SOX9, and its overexpression or knockdown affects VSMC calcification. Silencing SOX9 expression significantly inhibits phosphate- and calcium-induced VSMC calcification.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Isao Tamura, Amon Shiroshita, Taishi Fujimura, Yumiko Tanaka-Doi, Yuichiro Shirafuta, Toshiaki Taketani, Shun Sato, Norihiro Sugino
Summary: Decidualization is a critical process for embryo implantation and pregnancy establishment. It involves dramatic changes in metabolic functions of human endometrial stromal cells (hESCs). Glucose metabolism and lipid metabolism undergo significant alterations during decidualization, including increased glucose uptake mediated by GLUT1 and lipid accumulation mediated by VLDLR respectively. These metabolic changes may contribute to the successful implantation and provide nutrition to the developing embryo.
Article
Biochemistry & Molecular Biology
Xiaoyan Jing, Wei Sun, Xiaoyu Yang, Hui Huang, Ping Wang, Qun Luo, Shu Xia, Chuling Fang, Qian Zhang, Jian Guo, Zuojun Xu
Summary: This study found that in patients with pulmonary fibrosis, there is overexpression of CHOP, which is accompanied by alveolar epithelial cell senescence. The activation of CHOP pathway accelerates oxidative stress and the nuclear factor-kappa B pathway, leading to alveolar epithelial cell senescence and the development of pulmonary fibrosis.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Cell Biology
Qin Wang, Rong Fu, Gang Li, Shaojie Xiong, Yi Zhu, Huimin Zhang
Summary: Hedgehog signaling plays important roles in epithelial barrier tissues' development and homeostasis. The study reveals the direct regulation of innate immunity in epithelial cells by Hedgehog signaling. Loss of Patched family receptor induces up-regulation of antimicrobial peptides in epidermis through a STAT-dependent pathway. The findings demonstrate the immune-surveillance function of Hedgehog receptors and the insult-sensing and response strategy of epithelial tissues.
Article
Biochemistry & Molecular Biology
Monika J. Stankiewicz, Jian Du, Dominick Martinico, Steven J. Ackerman
Summary: C/EBP epsilon(27) acts as a potent repressor of MBP1 transcription in eosinophil differentiation by interacting with GATA-1 protein and binding to a C/EBP site in the MBP1 promoter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)