Recent Progress of Potentiating Immune Checkpoint Blockade with External Stimuli—an Industry Perspective

Top 10 Challenges in Cancer Immunotherapy

(2020) Priti S. Hegde et al.   IMMUNITY

Nanoparticle-Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy

(2019) Qian Chen et al.   ADVANCED MATERIALS

Molecular landmarks of tumor hypoxia across cancer types

(2019) Vinayak Bhandari et al.   NATURE GENETICS

Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study

(2019) Todd Mainprize et al.   Scientific Reports

Innovation in Chemistry, Manufacturing, and Controls—A Regulatory Perspective From Industry

(2019) Nina S. Cauchon et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Penetration of different molecule sizes upon ultrasound combined with microbubbles in a superficial tumour model

(2019) Yingli Wei et al.   JOURNAL OF DRUG TARGETING

Photothermal cancer immunotherapy by erythrocyte membrane-coated black phosphorus formulation

(2019) Xin Liang et al.   JOURNAL OF CONTROLLED RELEASE

Surgical Tumor-Derived Personalized Photothermal Vaccine Formulation for Cancer Immunotherapy

(2019) Xinyu Ye et al.   ACS Nano

Surface Functionalized Modified Copper Sulfide Nanoparticles Enhance Checkpoint Blockade Tumor Immunotherapy by Photothermal Therapy and Antigen-Capturing

(2019) Ruoping Wang et al.   ACS Applied Materials & Interfaces

Light‐Triggered In Situ Gelation to Enable Robust Photodynamic‐Immunotherapy by Repeated Stimulations

(2019) Zhouqi Meng et al.   ADVANCED MATERIALS

Tumor mutational burden (TMB) and response rates to immune checkpoint inhibitors (ICIs) targeting PD-1, CTLA-4, and combination.

(2019) Arsen Osipov et al.   JOURNAL OF CLINICAL ONCOLOGY

Response rate to chemotherapy after disease progression with anti-PD-1/PD-L1 in metastatic cancer.

(2019) Munaf Al-Kadhimi et al.   JOURNAL OF CLINICAL ONCOLOGY

Photothermal therapy mediated by phase-transformation nanoparticles facilitates delivery of anti-PD1 antibody and synergizes with antitumor immunotherapy for melanoma

(2019) Ni Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial

(2019) Tony S K Mok et al.   LANCET

Iron Nanoparticles for Low-power Local Magnetic Hyperthermia in Combination with Immune Checkpoint Blockade for Systemic Antitumor Therapy

(2019) Yu Chao et al.   NANO LETTERS

Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance

(2019) Filipe Martins et al.   Nature Reviews Clinical Oncology

The global pipeline of cell therapies for cancer

(2019) Jia Xin Yu et al.   NATURE REVIEWS DRUG DISCOVERY

Cancer nanomedicine for combination cancer immunotherapy

(2019) Jutaek Nam et al.   Nature Reviews Materials

Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis

(2019) Xiaoli Liu et al.   ACS Nano

In Situ Nanoadjuvant-Assembled Tumor Vaccine for Preventing Long-Term Recurrence

(2019) Quoc-Viet Le et al.   ACS Nano

Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma

(2019) Antoni Ribas et al.   NATURE MEDICINE

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

(2019) Wei Li et al.   Nature Communications

Nanoscale Metal-Organic Framework Mediates Radical Therapy to Enhance Cancer Immunotherapy

(2019) Kaiyuan Ni et al.   Chem

Engineering nanoparticles to locally activate T cells in the tumor microenvironment

(2019) Dangge Wang et al.   Science Immunology

Cold to Hot: Rational Design of a Minimalist Multifunctional Photo-immunotherapy Nanoplatform toward Boosting Immunotherapy Capability

(2019) Di Zhang et al.   ACS Applied Materials & Interfaces

High Affinity of Chlorin e6 to Immunoglobulin G for Intraoperative Fluorescence Image-Guided Cancer Photodynamic and Checkpoint Blockade Therapy

(2019) Jiaojiao Xu et al.   ACS Nano

Self‐Amplified Drug Delivery with Light‐Inducible Nanocargoes to Enhance Cancer Immunotherapy

(2019) Bing Feng et al.   ADVANCED MATERIALS

Rationally designed peptide-conjugated gold/platinum nanosystem with active tumor-targeting for enhancing tumor photothermal-immunotherapy

(2019) Qian Yang et al.   JOURNAL OF CONTROLLED RELEASE

Integration of radiotherapy and immunotherapy for treatment of oligometastases

(2019) Sean P Pitroda et al.   LANCET ONCOLOGY

Radioimmunotherapy for the treatment of head and neck cancer

(2019) Sana D Karam et al.   LANCET ONCOLOGY

Optimising efficacy and reducing toxicity of anticancer radioimmunotherapy

(2019) Eric Deutsch et al.   LANCET ONCOLOGY

Nanoparticle Size Influences Antigen Retention and Presentation in Lymph Node Follicles for Humoral Immunity

(2019) Yi-Nan Zhang et al.   NANO LETTERS

Intrinsic chemistry and design principle of ultrasound-responsive nanomedicine

(2019) Xinwu Cui et al.   Nano Today

The emerging role of epigenetic therapeutics in immuno-oncology

(2019) Michael J. Topper et al.   Nature Reviews Clinical Oncology

Combining epigenetic drugs with other therapies for solid tumours — past lessons and future promise

(2019) Daphné Morel et al.   Nature Reviews Clinical Oncology

Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study

(2019) Ardeshir R. Rastinehad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Janus Nanobullets Combine Photodynamic Therapy and Magnetic Hyperthermia to Potentiate Synergetic Anti‐Metastatic Immunotherapy

(2019) Zheng Wang et al.   Advanced Science

Lyophilizable and Multifaceted Toll-like Receptor 7/8 Agonist-Loaded Nanoemulsion for the Reprogramming of Tumor Microenvironments and Enhanced Cancer Immunotherapy

(2019) Sun-Young Kim et al.   ACS Nano

Sequentially responsive biomimetic nanoparticles with optimal size in combination with checkpoint blockade for cascade synergetic treatment of breast cancer and lung metastasis

(2019) Wenqi Yu et al.   BIOMATERIALS

Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer

(2019) Wei Sun et al.   BIOMATERIALS

Harnessing innate immunity in cancer therapy

(2019) Olivier Demaria et al.   NATURE

A luminal unfolding microneedle injector for oral delivery of macromolecules

(2019) Alex Abramson et al.   NATURE MEDICINE

First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

(2019) Agessandro Abrahao et al.   Nature Communications

Difference in Acquired Radioresistance Induction Between Repeated Photon and Particle Irradiation

(2019) Katsutoshi Sato et al.   Frontiers in Oncology

Enhanced Immunotherapy Based on Photodynamic Therapy for Both Primary and Lung Metastasis Tumor Eradication

(2018) Wen Song et al.   ACS Nano

Evolution of Nanoparticle Protein Corona across the Blood–Brain Barrier

(2018) Alysia Cox et al.   ACS Nano

Size/Charge Changeable Acidity-Responsive Micelleplex for Photodynamic-Improved PD-L1 Immunotherapy with Enhanced Tumor Penetration

(2018) Liangliang Dai et al.   ADVANCED FUNCTIONAL MATERIALS

TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy

(2018) Lan Huang et al.   Cellular & Molecular Immunology

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

(2018) Giancarlo Canavese et al.   CHEMICAL ENGINEERING JOURNAL

Organic molecule-based photothermal agents: an expanding photothermal therapy universe

(2018) Hyo Sung Jung et al.   CHEMICAL SOCIETY REVIEWS

Recent progress in two-dimensional inorganic quantum dots

(2018) Yuanhong Xu et al.   CHEMICAL SOCIETY REVIEWS

Facilitating the translation of nanomedicines to a clinical product: challenges and opportunities

(2018) Vibhuti Agrahari et al.   DRUG DISCOVERY TODAY

Dose-limiting Urinary Toxicity With Pembrolizumab Combined With Weekly Hypofractionated Radiation Therapy in Bladder Cancer

(2018) Alison Claire Tree et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Sustained release of anti-PD-1 peptide for perdurable immunotherapy together with photothermal ablation against primary and distant tumors

(2018) Lihua Luo et al.   JOURNAL OF CONTROLLED RELEASE

Nanoscale Metal–Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy

(2018) Guangxu Lan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Smart Nanoreactors for pH-Responsive Tumor Homing, Mitochondria-Targeting, and Enhanced Photodynamic-Immunotherapy of Cancer

(2018) Guangbao Yang et al.   NANO LETTERS

Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy

(2018) Chih-Sheng Chiang et al.   Nature Nanotechnology

Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy

(2018) Kaiyuan Ni et al.   Nature Communications

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

(2018) Nir Lipsman et al.   Nature Communications

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

(2018) Yan Liu et al.   Theranostics

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

(2018) Susan Hua et al.   Frontiers in Pharmacology

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy

(2018) Jinrong Peng et al.   Advanced Science

Efficacy of combined hypo-fractionated radiotherapy and anti-PD-1 monotherapy in difficult-to-treat advanced melanoma patients

(2018) Anissa Roger et al.   OncoImmunology

Low-dose X-ray radiotherapy–radiodynamic therapy via nanoscale metal–organic frameworks enhances checkpoint blockade immunotherapy

(2018) Kuangda Lu et al.   Nature Biomedical Engineering

Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses

(2018) Yu Chao et al.   Nature Biomedical Engineering

Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

(2018) Yijing Liu et al.   CHEMICAL SOCIETY REVIEWS

Overview of ongoing clinical trials investigating combined radiotherapy and immunotherapy

(2018) Taylor R Cushman et al.   Immunotherapy

EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer

(2018) Yuan Li et al.   Nanoscale

The therapeutic significance of mutational signatures from DNA repair deficiency in cancer

(2018) Jennifer Ma et al.   Nature Communications

Nanomedicine: Principles, Properties, and Regulatory Issues

(2018) Sara Soares et al.   Frontiers in Chemistry

Nanoscale Reduced Graphene Oxide-Mediated Photothermal Therapy Together with IDO Inhibition and PD-L1 Blockade Synergistically Promote Antitumor Immunity

(2018) Mengmeng Yan et al.   ACS Applied Materials & Interfaces

Recent insights in magnetic hyperthermia: From the “hot-spot” effect for local delivery to combined magneto-photo-thermia using magneto-plasmonic hybrids

(2018) Esther Cazares-Cortes et al.   ADVANCED DRUG DELIVERY REVIEWS

Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study

(2018) Ezra E W Cohen et al.   LANCET

Trial watch: The clinical trial landscape for PD1/PDL1 immune checkpoint inhibitors

(2018) Jun Tang et al.   NATURE REVIEWS DRUG DISCOVERY

Magnetic Drug Delivery: Where the Field Is Going

(2018) Paige M. Price et al.   Frontiers in Chemistry

Enhancing Checkpoint Inhibitor Therapy with Ultrasound Stimulated Microbubbles

(2018) Sharshi Bulner et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial

(2017) Narek Shaverdian et al.   LANCET ONCOLOGY

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

(2017) Mark Yarchoan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis

(2017) Rajeev K. Shrimali et al.   Cancer Immunology Research

Photodynamic-Immune Checkpoint Therapy Eradicates Local and Distant Tumors by CD8 + T Cells

(2017) Jan Willem Kleinovink et al.   Cancer Immunology Research

Liposomal Formulations in Clinical Use: An Updated Review

(2017) Upendra Bulbake et al.   Pharmaceutics

Nanoscale metal–organic frameworks for phototherapy of cancer

(2017) Guangxu Lan et al.   COORDINATION CHEMISTRY REVIEWS

Magnetic Nanoparticle Facilitated Drug Delivery for Cancer Therapy with Targeted and Image-Guided Approaches

(2016) Jing Huang et al.   ADVANCED FUNCTIONAL MATERIALS

Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies

(2016) Karel Ulbrich et al.   CHEMICAL REVIEWS

MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade

(2016) Peter J.R. Ebert et al.   IMMUNITY

Anti-PD-1 Therapy and Stereotactic Radiation for Melanoma and Non-Small Cell Lung Cancer Patients with Brain Metastases: A 2-Institution Series

(2016) A.C. Olson et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Penetration depth of photons in biological tissues from hyperspectral imaging in shortwave infrared in transmission and reflection geometries

(2016) Hairong Zhang et al.   JOURNAL OF BIOMEDICAL OPTICS

A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer

(2016) Georg Dimcevski et al.   JOURNAL OF CONTROLLED RELEASE

Photodynamic Therapy Mediated by Nontoxic Core–Shell Nanoparticles Synergizes with Immune Checkpoint Blockade To Elicit Antitumor Immunity and Antimetastatic Effect on Breast Cancer

(2016) Xiaopin Duan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Size-Controlled Synthesis of Porphyrinic Metal–Organic Framework and Functionalization for Targeted Photodynamic Therapy

(2016) Jihye Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chlorin-Based Nanoscale Metal–Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy

(2016) Kuangda Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

(2016) Roy S Herbst et al.   LANCET

Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study

(2016) Corey J Langer et al.   LANCET ONCOLOGY

Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy

(2016) Dangge Wang et al.   NANO LETTERS

Mechanism of hard-nanomaterial clearance by the liver

(2016) Kim M. Tsoi et al.   NATURE MATERIALS

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

Tailoring nanoparticle designs to target cancer based on tumor pathophysiology

(2016) Edward A. Sykes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

(2016) Andrew J. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The "cancer immunogram"

(2016) C. U. Blank et al.   SCIENCE

Challenges in preclinical to clinical translation for anticancer carrier-mediated agents

(2016) Andrew T. Lucas et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

(2016) Chunbai He et al.   Nature Communications

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

(2016) Qian Chen et al.   Nature Communications

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Regulatory aspects on nanomedicines

(2015) Vanessa Sainz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nanoparticles in Photodynamic Therapy

(2015) Sasidharan Swarnalatha Lucky et al.   CHEMICAL REVIEWS

Ultraviolet light-mediated drug delivery: Principles, applications, and challenges

(2015) Aoune Barhoumi et al.   JOURNAL OF CONTROLLED RELEASE

Big opportunities for small molecules in immuno-oncology

(2015) Jerry L. Adams et al.   NATURE REVIEWS DRUG DISCOVERY

Vaccines, Adjuvants, and Dendritic Cell Activators—Current Status and Future Challenges

(2015) Joseph Obeid et al.   SEMINARS IN ONCOLOGY

Dissecting the Molecular Mechanism of Apoptosis during Photothermal Therapy Using Gold Nanoprisms

(2014) Marta Pérez-Hernández et al.   ACS Nano

Investigating the Impact of Nanoparticle Size on Active and Passive Tumor Targeting Efficiency

(2014) Edward A. Sykes et al.   ACS Nano

Ultrasound induced cancer immunotherapy

(2014) Johan Unga et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanomedicines: addressing the scientific and regulatory gap

(2014) Sally Tinkle et al.   Annals of the New York Academy of Sciences

Rod-shaped iron oxide nanoparticles are more toxic than sphere-shaped nanoparticles to murine macrophage cells

(2014) Jang Han Lee et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Nanoscale Metal–Organic Framework for Highly Effective Photodynamic Therapy of Resistant Head and Neck Cancer

(2014) Kuangda Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment

(2014) Stefani Spranger et al.   Journal for ImmunoTherapy of Cancer

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Emerging Research and Clinical Development Trends of Liposome and Lipid Nanoparticle Drug Delivery Systems

(2013) John C. Kraft et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Treatment of human pancreatic cancer using combined ultrasound, microbubbles, and gemcitabine: A clinical case study

(2013) Spiros Kotopoulis et al.   MEDICAL PHYSICS

The Chemistry and Applications of Metal-Organic Frameworks

(2013) H. Furukawa et al.   SCIENCE

Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle

(2013) Shruti R Saptarshi et al.   JOURNAL OF NANOBIOTECHNOLOGY

Various modes of cell death induced by DNA damage

(2012) O Surova et al.   ONCOGENE

Clinical effects of in situ photoimmunotherapy on late-stage melanoma patients

(2011) Xiaosong Li et al.   CANCER BIOLOGY & THERAPY

The immunosuppressive side of PDT

(2011) Pawel Mroz et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Nanoparticle-mediated cellular response is size-dependent

(2008) Wen Jiang et al.   Nature Nanotechnology