Magnetic Nanoparticle Facilitated Drug Delivery for Cancer Therapy with Targeted and Image-Guided Approaches

Current state and future applications of active targeting in malignancies using superparamagnetic iron oxide nanoparticles

(2017) Tina Islam et al.   Cancer Biomarkers

IGF1 Receptor Targeted Theranostic Nanoparticles for Targeted and Image-Guided Therapy of Pancreatic Cancer

(2015) Hongyu Zhou et al.   ACS Nano

PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual-Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer

(2015) Xiaolong Liang et al.   ADVANCED FUNCTIONAL MATERIALS

A New Single 808 nm NIR Light-Induced Imaging-Guided Multifunctional Cancer Therapy Platform

(2015) Fei He et al.   ADVANCED FUNCTIONAL MATERIALS

Co9Se8Nanoplates as a New Theranostic Platform for Photoacoustic/Magnetic Resonance Dual-Modal-Imaging-Guided Chemo-Photothermal Combination Therapy

(2015) Xiao-Rong Song et al.   ADVANCED MATERIALS

Two-dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer

(2015) Guangbao Yang et al.   BIOMATERIALS

Layer-by-layer assembled milk protein coated magnetic nanoparticle enabled oral drug delivery with high stability in stomach and enzyme-responsive release in small intestine

(2015) Jing Huang et al.   BIOMATERIALS

FeS nanoplates as a multifunctional nano-theranostic for magnetic resonance imaging guided photothermal therapy

(2015) Kai Yang et al.   BIOMATERIALS

Treatment of Invasive Brain Tumors Using a Chain-like Nanoparticle

(2015) P. M. Peiris et al.   CANCER RESEARCH

Photosensitizer conjugated iron oxide nanoparticles for simultaneous in vitro magneto-fluorescent imaging guided photodynamic therapy

(2015) Md Nafiujjaman et al.   CHEMICAL COMMUNICATIONS

GEM-loaded magnetic albumin nanospheres modified with cetuximab for simultaneous targeting, magnetic resonance imaging, and double-targeted thermochemotherapy of pancreatic cancer cells

(2015) Ling Wang et al.   International Journal of Nanomedicine

A collagen-binding EGFR single-chain Fv antibody fragment for the targeted cancer therapy

(2015) Hui Liang et al.   JOURNAL OF CONTROLLED RELEASE

Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound

(2015) S. Rizzitelli et al.   JOURNAL OF CONTROLLED RELEASE

RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T1-weighted MR imaging of gliomas

(2015) Yu Luo et al.   Nanoscale

Design of an intelligent sub-50 nm nuclear-targeting nanotheranostic system for imaging guided intranuclear radiosensitization

(2015) Wenpei Fan et al.   Chemical Science

Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting

(2015) Munitta Muthana et al.   Nature Communications

Theranostic Mesoporous Silica Nanoparticles Biodegrade after Pro-Survival Drug Delivery and Ultrasound/Magnetic Resonance Imaging of Stem Cells

(2015) Paul J. Kempen et al.   Theranostics

Optimized Metal–Organic-Framework Nanospheres for Drug Delivery: Evaluation of Small-Molecule Encapsulation

(2014) Jia Zhuang et al.   ACS Nano

Theranostic USPIO-Loaded Microbubbles for Mediating and Monitoring Blood-Brain Barrier Permeation

(2014) Twan Lammers et al.   ADVANCED FUNCTIONAL MATERIALS

MRI/SPECT/Fluorescent Tri-Modal Probe for Evaluating the Homing and Therapeutic Efficacy of Transplanted Mesenchymal Stem Cells in a Rat Ischemic Stroke Model

(2014) Yaohui Tang et al.   ADVANCED FUNCTIONAL MATERIALS

Engineering of Multifunctional Nano-Micelles for Combined Photothermal and Photodynamic Therapy Under the Guidance of Multimodal Imaging

(2014) Hua Gong et al.   ADVANCED FUNCTIONAL MATERIALS

Photothermal Killing of Cancer Cells by the Controlled Plasmonic Coupling of Silica-Coated Au/Fe2O3Nanoaggregates

(2014) Georgios A. Sotiriou et al.   ADVANCED FUNCTIONAL MATERIALS

Multifunctional Fe5C2Nanoparticles: A Targeted Theranostic Platform for Magnetic Resonance Imaging and Photoacoustic Tomography-Guided Photothermal Therapy

(2014) Jing Yu et al.   ADVANCED MATERIALS

Molecular Understanding and Design of Zwitterionic Materials

(2014) Qing Shao et al.   ADVANCED MATERIALS

Magnetic graphene-based nanotheranostic agent for dual-modality mapping guided photothermal therapy in regional lymph nodal metastasis of pancreatic cancer

(2014) Sheng Wang et al.   BIOMATERIALS

Biodegradable polymeric vesicles containing magnetic nanoparticles, quantum dots and anticancer drugs for drug delivery and imaging

(2014) Fei Ye et al.   BIOMATERIALS

Magnetic Hyperthermia with Magnetic Nanoparticles: A Status Review

(2014) A.B. Salunkhe et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

EPR: Evidence and fallacy

(2014) Joseph W. Nichols et al.   JOURNAL OF CONTROLLED RELEASE

Multifunctional Tumor pH-Sensitive Self-Assembled Nanoparticles for Bimodal Imaging and Treatment of Resistant Heterogeneous Tumors

(2014) Daishun Ling et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A carbon nanotube–polymer composite for T-cell therapy

(2014) Tarek R. Fadel et al.   Nature Nanotechnology

ICAM-1 as a molecular target for triple negative breast cancer

(2014) P. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Multifunctional Nanoplatform for Imaging, Radiotherapy, and the Prediction of Therapeutic Response

(2014) Casey McQuade et al.   Small

Aptamer-conjugated nanomaterials for specific cancer cell recognition and targeted cancer therapy

(2014) Qiaoling Liu et al.   NPG Asia Materials

Longitudinal Monitoring of Stem Cell Grafts In Vivo Using Magnetic Resonance Imaging with Inducible Maga as a Genetic Reporter

(2014) In K. Cho et al.   Theranostics

Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release

(2014) Koichiro Hayashi et al.   Theranostics

Smart pH-Responsive Nanocarriers Based on Nano-Graphene Oxide for Combined Chemo- and Photothermal Therapy Overcoming Drug Resistance

(2014) Liangzhu Feng et al.   Advanced Healthcare Materials

Facile non-hydrothermal synthesis of oligosaccharide coated sub-5 nm magnetic iron oxide nanoparticles with dual MRI contrast enhancement effects

(2014) Jing Huang et al.   Journal of Materials Chemistry B

Casein-Coated Iron Oxide Nanoparticles for High MRI Contrast Enhancement and Efficient Cell Targeting

(2013) Jing Huang et al.   ACS Applied Materials & Interfaces

Theranostic Nanoparticles with Controlled Release of Gemcitabine for Targeted Therapy and MRI of Pancreatic Cancer

(2013) Gee Young Lee et al.   ACS Nano

Image-Guided Local Delivery Strategies Enhance Therapeutic Nanoparticle Uptake in Solid Tumors

(2013) Samdeep K. Mouli et al.   ACS Nano

Ultra-Small Iron Oxide Doped Polypyrrole Nanoparticles for In Vivo Multimodal Imaging Guided Photothermal Therapy

(2013) Xuejiao Song et al.   ADVANCED FUNCTIONAL MATERIALS

Magnetic Targeting Enhanced Theranostic Strategy Based on Multimodal Imaging for Selective Ablation of Cancer

(2013) Zhiwei Li et al.   ADVANCED FUNCTIONAL MATERIALS

Functional Iron Oxide Magnetic Nanoparticles with Hyperthermia-Induced Drug Release Ability by Using a Combination of Orthogonal Click Reactions

(2013) Thuy T. T. N'Guyen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery

(2013) Ching-Hsiang Fan et al.   BIOMATERIALS

Ultrashort Echo Time (UTE) imaging of receptor targeted magnetic iron oxide nanoparticles in mouse tumor models

(2013) Liya Wang et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Targeted Delivery of siRNA-Generating DNA Nanocassettes Using Multifunctional Nanoparticles

(2013) Young-Seok Cho et al.   Small

Surfactant-Free, Lipo-Polymersomes Stabilized by Iron Oxide Nanoparticles/Polymer Interlayer for Synergistically Targeted and Magnetically Guided Gene Delivery

(2013) Shang-Hsiu Hu et al.   Advanced Healthcare Materials

Synthesis and In Vivo Pharmacokinetic Evaluation of Degradable Shell Cross-Linked Polymer Nanoparticles with Poly(carboxybetaine) versus Poly(ethylene glycol) Surface-Grafted Coatings

(2012) Ang Li et al.   ACS Nano

Preventing Protein Adsorption and Macrophage Uptake of Gold Nanoparticles via a Hydrophobic Shield

(2012) Timothy A. Larson et al.   ACS Nano

In Vivo Clearance and Toxicity of Monodisperse Iron Oxide Nanocrystals

(2012) Luo Gu et al.   ACS Nano

Targeted Chemo-Photothermal Treatments of Rheumatoid Arthritis Using Gold Half-Shell Multifunctional Nanoparticles

(2012) Sun-Mi Lee et al.   ACS Nano

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

(2012) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications

(2012) L. Harivardhan Reddy et al.   CHEMICAL REVIEWS

General Route to Multifunctional Uniform Yolk/Mesoporous Silica Shell Nanocapsules: A Platform for Simultaneous Cancer-Targeted Imaging and Magnetically Guided Drug Delivery

(2012) Lingyu Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Magnetic and pH-sensitive nanoparticles for antitumor drug delivery

(2012) Shufang Yu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Dextran and Polymer Polyethylene Glycol (PEG) Coating Reduce Both 5 and 30 nm Iron Oxide Nanoparticle Cytotoxicity in 2D and 3D Cell Culture

(2012) Miao Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Paclitaxel and iron oxide loaded multifunctional nanoparticles for chemotherapy, fluorescence properties, and magnetic resonance imaging

(2012) Yung-Chu Chen et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Allylic C–H Activations Using Cu(II) 2-Quinoxalinol Salen and tert-Butyl Hydroperoxide

(2012) Yuancheng Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Increased Tumor Homing and Tissue Penetration of the Filamentous Plant Viral Nanoparticle Potato virus X

(2012) Sourabh Shukla et al.   MOLECULAR PHARMACEUTICS

Conjugation of paclitaxel to iron oxide nanoparticles for tumor imaging and therapy

(2012) Dongfang Liu et al.   Nanoscale

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Improving the Magnetic Resonance Imaging Contrast and Detection Methods with Engineered Magnetic Nanoparticles

(2012) Jing Huang et al.   Theranostics

Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy

(2011) Carlos Tassa et al.   ACCOUNTS OF CHEMICAL RESEARCH

Smart Drug Delivery through DNA/Magnetic Nanoparticle Gates

(2011) Eduardo Ruiz-Hernández et al.   ACS Nano

Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy

(2011) Charles Sanson et al.   ACS Nano

Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery

(2011) Challa S.S.R. Kumar et al.   ADVANCED DRUG DELIVERY REVIEWS

cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging

(2011) Xiaoqiang Yang et al.   BIOMATERIALS

Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma

(2011) Matias E. Valsecchi et al.   CANCER

Clinical development of liposome based drugs: formulation, characterization, and therapeutic efficacy

(2011) Ming-Kung Yeh et al.   International Journal of Nanomedicine

Novel water-soluble and pH-responsive anticancer drug nanocarriers: Doxorubicin–PAMAM dendrimer conjugates attached to superparamagnetic iron oxide nanoparticles (IONPs)

(2011) Yulei Chang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Triggered Release from Liposomes through Magnetic Actuation of Iron Oxide Nanoparticle Containing Membranes

(2011) Esther Amstad et al.   NANO LETTERS

Iron oxide nanoparticles for targeted cancer imaging and diagnostics

(2011) Joshua E. Rosen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoplex Delivery of siRNA and Prodrug Enzyme for Multimodality Image-Guided Molecular Pathway Targeted Cancer Therapy

(2010) Cong Li et al.   ACS Nano

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Anti-Estrogen-Loaded Superparamagnetic Liposomes for Intracellular Magnetic Targeting and Treatment of Breast Cancer Tumors

(2010) Vincent Plassat et al.   ADVANCED FUNCTIONAL MATERIALS

Reducing non-specific binding and uptake of nanoparticles and improving cell targeting with an antifouling PEO-b-PγMPS copolymer coating

(2010) Hongwei Chen et al.   BIOMATERIALS

Polyethyleneimine-modified iron oxide nanoparticles for brain tumor drug delivery using magnetic targeting and intra-carotid administration

(2010) Beata Chertok et al.   BIOMATERIALS

Image-Guided Breast Tumor Therapy Using a Small Interfering RNA Nanodrug

(2010) M. Kumar et al.   CANCER RESEARCH

EGFRvIII Antibody-Conjugated Iron Oxide Nanoparticles for Magnetic Resonance Imaging-Guided Convection-Enhanced Delivery and Targeted Therapy of Glioblastoma

(2010) C. G. Hadjipanayis et al.   CANCER RESEARCH

Magnetic nanoparticle hyperthermia for prostate cancer

(2010) Manfred Johannsen et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Enhanced noscapine delivery using uPAR-targeted optical-MR imaging trackable nanoparticles for prostate cancer therapy

(2010) Mohamed O. Abdalla et al.   JOURNAL OF CONTROLLED RELEASE

T1-weighted ultrashort echo time method for positive contrast imaging of magnetic nanoparticles and cancer cells bound with the targeted nanoparticles

(2010) Longjiang Zhang et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme

(2010) Klaus Maier-Hauff et al.   JOURNAL OF NEURO-ONCOLOGY

An Effective Method for Allylic Oxidation of Δ5-Steroids Usingtert-Butyl Hydroperoxide

(2010) Yuancheng Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles

(2010) Courtney R. Thomas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding and overcoming major barriers in cancer nanomedicine

(2010) Shuming Nie   Nanomedicine

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology

Ligands for Mapping αvβ3-Integrin Expression in Vivo

(2009) Margret Schottelius et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biocompatible Polysiloxane-Containing Diblock Copolymer PEO-b-PγMPS for Coating Magnetic Nanoparticles

(2009) Hongwei Chen et al.   ACS Applied Materials & Interfaces

Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging

(2009) Omid Veiseh et al.   ADVANCED DRUG DELIVERY REVIEWS

PEI-PEG-Chitosan-Copolymer-Coated Iron Oxide Nanoparticles for Safe Gene Delivery: Synthesis, Complexation, and Transfection

(2009) Forrest M. Kievit et al.   ADVANCED FUNCTIONAL MATERIALS

Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting

(2009) Kai Chen et al.   BIOMATERIALS

Molecular Imaging of Pancreatic Cancer in an Animal Model Using Targeted Multifunctional Nanoparticles

(2009) Lily Yang et al.   GASTROENTEROLOGY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Regulation of cell signalling by uPAR

(2009) Harvey W. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multifunctional magnetic nanoparticles for targeted imaging and therapy☆

(2008) J MCCARTHY et al.   ADVANCED DRUG DELIVERY REVIEWS

Magnetic nanoparticles in MR imaging and drug delivery☆

(2008) C SUN et al.   ADVANCED DRUG DELIVERY REVIEWS

In VivoTumor Cell Targeting with “Click” Nanoparticles

(2008) Geoffrey von Maltzahn et al.   BIOCONJUGATE CHEMISTRY

Magnetic nanoparticles with dual functional properties: Drug delivery and magnetic resonance imaging

(2008) Tapan K. Jain et al.   BIOMATERIALS

Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy

(2008) Andrew Z. Wang et al.   ChemMedChem

Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect

(2008) H. Maeda et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Targeted Herceptin–dextran iron oxide nanoparticles for noninvasive imaging of HER2/neu receptors using MRI

(2008) Ting-Jung Chen et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Development of Receptor Targeted Magnetic Iron Oxide Nanoparticles for Efficient Drug Delivery and Tumor Imaging

(2008) Lily Yang et al.   Journal of Biomedical Nanotechnology

Magnetic and pH-responsive nanocarriers with multilayer core–shell architecture for anticancer drug delivery

(2008) Miao Guo et al.   JOURNAL OF MATERIALS CHEMISTRY

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

(2008) Michelle Longmire et al.   Nanomedicine

Magnetic nanoparticles as gene delivery agents: enhanced transfection in the presence of oscillating magnet arrays

(2008) S C McBain et al.   NANOTECHNOLOGY

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles

(2008) S. Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo MRI Detection of Gliomas by Chlorotoxin-Conjugated Superparamagnetic Nanoprobes

(2008) Conroy Sun et al.   Small

Single Chain Epidermal Growth Factor Receptor Antibody Conjugated Nanoparticles for in vivo Tumor Targeting and Imaging

(2008) Lily Yang et al.   Small

Metallic Iron Nanoparticles for MRI Contrast Enhancement and Local Hyperthermia

(2008) Costas G. Hadjipanayis et al.   Small

Targeted folic acid-PEG nanoparticles for noninvasive imaging of folate receptor by MRI

(2007) Ting-Jung Chen et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Laboratory formulated magnetic nanoparticles for enhancement of viral gene expression in suspension cell line

(2007) Shanta Raj Bhattarai et al.   JOURNAL OF VIROLOGICAL METHODS