Article
Chemistry, Physical
Pawel Peczkowski, Ryszard Zalecki, Piotr Zachariasz, Elzbieta Szostak, Jaroslaw Pietosa, Marcin Turek, Krzysztof Pyszniak, Marcin Zajac, Joanna Czub, Lukasz Gondek
Summary: We discuss changes in properties of Gd-based high-temperature superconducting tapes induced by 250 keV Ne+ ions irradiation. Ionizing radiation can introduce defects to the microstructure of tapes, leading to deterioration of the superconducting parameters. The critical current densities are reduced by 33% - 60% compared to the reference sample.
APPLIED SURFACE SCIENCE
(2023)
Article
Oncology
Yen-Yun Wang, Amos C. Hung, Steven Lo, Ya-Ching Hsieh, Shyng-Shiou F. Yuan
Summary: MRE11 plays a crucial role in DNA damage response and its expression in cancer cells is linked to radioresistance, making it a potential marker for radiosensitization strategies. Elevated MRE11 in tumor tissues has been associated with poor survival in radiotherapy patients, although recent findings of ionizing radiation-induced truncation of MRE11 may explain some conflicting observations. Advancements in understanding the biological modulation of MRE11 expression and the potential application of inhibitors for enhancing radiosensitivity are discussed, highlighting the importance of distinguishing between nuclease and non-nuclease activities of MRE11 in cancer cells treated with ionizing radiation.
Article
Polymer Science
Linas Kudrevicius, Diana Adliene, Judita Puiso, Aurimas Plaga
Summary: Occupational radiation exposure monitoring is well-established, but occasional exposure remains a challenge. In this study, radiation-sensitive films using PVA-based hydrogels with organic dyes or Ag nanoparticles were developed. Experimental samples were irradiated and evaluated for radiation sensitivity. The PVA-BB films showed the highest sensitivity in the low-dose range. These colored hydrogel films can serve as indicators to assess the occasional radiation exposure.
Article
Chemistry, Analytical
Albert Doblas, David Flores, Salvador Hidalgo, Neil Moffat, Giulio Pellegrini, David Quirion, Jairo Villegas, Dzmitry Maneuski, Marie Ruat, Pablo Fajardo
Summary: Pixelated LGADs have been established as the baseline technology for timing detectors in ATLAS and CMS experiments. Inverse LGAD (iLGAD) technology has been proposed to overcome the non-gain area issue and enhance tracking capabilities. This study explores the use of iLGAD sensors for surface damage irradiation and develops a new generation of iLGADs with optimized performance.
Article
Chemistry, Inorganic & Nuclear
Kadir Yaray, Abdolvahed Norbakhsh, Hamid Rashidzadeh, Ali Mohammadi, Faezeh Mozafari, Mohammadreza Ghaffarlou, Navid Mousazadeh, Reza Ghaderzadeh, Yadollah Ghorbani, Leila Nasehi, Hossein Danafar, Yavuz Nuri Ertas
Summary: Bovine serum albumin (BSA) coated platinum (Pt) nanoparticles (Pt@BSA NPs) were synthesized and conjugated with an anticancer drug (MTX) for chemoradiation therapy. The physical and chemical properties of Pt@BSA-MTX were evaluated using various techniques. The release behavior of Pt@BSA-MTX depended on the presence of enzyme, which accelerated the release of MTX. The combination of a nanoradiosensitizer with a chemotherapeutic agent demonstrated superior anticancer activity after X-ray exposure in vitro.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Oncology
Camille Huart, Maude Fransolet, Catherine Demazy, Benjamin Le Calve, Stephane Lucas, Carine Michiels, Anne-Catherine Wera
Summary: Combining radiation, Olaparib, and ABT-263 can effectively target radio-induced senescent cells, increasing cell death and reducing the senescence-associated secretory phenotype. This study provides a new therapeutic combination for patients treated with radiotherapy and Olaparib.
Article
Chemistry, Physical
Hans de Brouwer
Summary: This article compares the effects of x-ray and gamma radiation on the mechanical properties and color of five different engineering resins commonly used in medical devices. The study shows that both types of radiation have similar effects on the materials at the same dose. However, the impact of radiation on the tensile and impact test results is minimal except for the stress at yield point for polycarbonate. Color is strongly influenced by radiation, but a radiation stabilized polycarbonate with color compensation technology can be used to produce sterilized parts with a neutral appearance.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Oncology
Natalia V. Bogdanova, Nina Jguburia, Dhanya Ramachandran, Nora Nischik, Katharina Stemwedel, Georg Stamm, Thomas Werncke, Frank Wacker, Thilo Dork, Hans Christiansen
Summary: In this study, the impact of repeated chest CT scans on the efficiency of DNA double-strand break (DSB) repair was investigated, with repair focus levels reaching up to 30% of those after 2 Gy irradiation and elevated persistent focus levels lasting up to 6 months. This memory effect may reflect a radiation-induced long-term response of cells after low-dose X-ray exposure.
FRONTIERS IN ONCOLOGY
(2021)
Article
Polymer Science
Giulia Tamburini, Stefano Bertagnoli, Giulia Tarricone, Sergio Piva, Adele Sassella, Roberto Lorenzi, Alberto Paleari
Summary: A spectroscopic study on the initial stages of radiation-induced modifications in poly(lactic acid) (PLA) revealed the emergence of molecular unit perturbations, mainly related to methyl and carbonyl groups with the formation of C=C double bonds.
POLYMER DEGRADATION AND STABILITY
(2023)
Article
Biochemistry & Molecular Biology
Weiling Liu, Chuanwang Miao, Shaosen Zhang, Yachen Liu, Xiangjie Niu, Yiyi Xi, Wenjia Guo, Jiahui Chu, Ai Lin, Hongjin Liu, Xinyu Yang, Xinjie Chen, Ce Zhong, Yuling Ma, Yuqian Wang, Shihao Zhu, Shuning Liu, Wen Tan, Dongxin Lin, Chen Wu
Summary: This study reveals the important role of overexpressed VAV2 in human cancers, which can impact the efficacy of radiotherapy. VAV2 affects DNA damage repair and signaling pathways, leading to radioresistance in tumors.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Nanoscience & Nanotechnology
Vishnu Kumar, Anuradha Bhogra, Manju Bala, Hung-Wei Kuo, Chi-Liang Chen, Chung-Li Dong, Asokan Kandasami, Annapoorni Subramanian
Summary: This study demonstrates the tuning of the optical bandgap of SrTiO3 films by electronic excitations induced by 125 MeV Ag ions. The X-ray diffraction pattern and X-ray absorption spectra (XAS) reveal significant changes in the local electronic structures, particularly in the distortion of TiO6 octahedra and the ratio of area under t(2g)/e(g). These findings provide insights into the role of structural properties and electronic structures in bandgap tuning.
SCRIPTA MATERIALIA
(2021)
Article
Agronomy
Shan Jiang, Li-Mei He, Wei He, Hui-Yuan Zhao, Xian-Ming Yang, Xue-Qing Yang, Kong-Ming Wu
Summary: Our laboratory experiments demonstrated the feasibility of using X-ray radiation for sterile insect technology (SIT) to control Spodoptera frugiperda in the field. X-ray irradiation had no significant effect on pupal eclosion, but females were more sensitive than males in terms of reproductive parameters. A sub-sterilizing dose of 250 Gy resulted in a high parental sterility rate and a continuous decrease in F-1 and F-2 generations.
PEST MANAGEMENT SCIENCE
(2022)
Article
Cell Biology
Vivek Kumar, Mohit Vashishta, Lin Kong, Jiade J. Lu, Xiaodong Wu, Bilikere S. Dwarakanath, Chandan Guha
Summary: Photon-based radiotherapy and carbon ion radiotherapy have different effects on Notch signaling in glioma cells. Carbon ion radiotherapy regulates the expression of Notch signaling and reduces stemness and cell migration. These findings may contribute to reducing tumor regrowth and disease dissemination.
Article
Oncology
Dinesh Kumar Tiwari, Ricarda Hannen, Kristian Unger, Sibylla Kohl, Julia Hess, Kirsten Lauber, Florentine S. B. Subtil, Ekkehard Dikomey, Rita Engenhart-Cabillic, Ulrike Schoetz
Summary: In this study, the effects of photon and C-12-ion irradiation on HPV-negative HNSCC cells were investigated. C-12-ion irradiation showed higher cell killing and residual DSBs compared to photon irradiation, and also induced more senescence. The expression of SASP-related genes and the IL1 pathway were strongly induced by both types of irradiation and correlated with radioresistance and senescence. However, knockdown of IL1A and IL1B revealed that the IL1 pathway is not functionally involved in radioresistance, DSB repair, or induction of senescence.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Qun Huang, Hao Chai, Shendong Wang, Yongming Sun, Wei Xu
Summary: Low-dose X-ray irradiation promotes cytoskeleton reorganization and differentiation of osteoblasts through the RhoA/ROCK signaling pathway. Inhibiting ROCK activity can block this process.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Liqiu Ma, Yoshimitsu Sakamoto, Akinori Kanai, Hiromi Otsuka, Akihisa Takahashi, Kazuhiro Kakimi, Takashi Imai, Takashi Shimokawa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Alexander Helm, Walter Tinganelli, Palma Simoniello, Fuki Kurosawa, Claudia Fournier, Takashi Shimokawa, Marco Durante
Summary: A combination of high-energy carbon ion radiation therapy and checkpoint inhibitors shows significant effectiveness in reducing the growth of abscopal tumors in a murine model, with carbon ions being more efficient in reducing lung metastases compared to x-rays. The infiltration of immune cells in the abscopal tumors increased in animals treated with the combination therapy, suggesting a potential for effective treatment of advanced tumors with this approach.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Horticulture
Tomoki Matsuyama, Manabu Watanabe, Yuri Murota, Nanako Nakata, Hisashi Kitamura, Takashi Shimokawa, Toshikazu Ebisuzaki, Satoshi Wada, Shusei Sato, Satoshi Tabata
SCIENTIA HORTICULTURAE
(2020)
Article
Public, Environmental & Occupational Health
Akinori Morita, Bing Wang, Kaoru Tanaka, Takanori Katsube, Masahiro Murakami, Takashi Shimokawa, Yuichi Nishiyama, Shintaro Ochi, Hidetoshi Satoh, Mitsuru Nenoi, Shin Aoki
FRONTIERS IN PUBLIC HEALTH
(2020)
Article
Nutrition & Dietetics
Megumi Ueno, Takashi Shimokawa, Emiko Sekine-Suzuki, Minako Nyui, Ikuo Nakanishi, Ken-Ichiro Matsumoto
Summary: A selenium deficient mouse model was successfully created by starting the mother on a selenium deficient diet 2 weeks after giving birth, showing sensitivity to oxidative stress induced by H2O2 and prolonged survival. This model may be useful for studying oxidative stress in vivo.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2021)
Article
Oncology
Yolanda Prezado, Ryochi Hirayama, Naruhiro Matsufuji, Taku Inaniwa, Immaculada Martinez-Rovira, Olivier Seksek, Annaig Bertho, Sachiko Koike, Dalila Labiod, Frederic Pouzoulet, Laura Polledo, Nils Warfving, Alethea Liens, Judith Bergs, Takashi Shimokawa
Summary: This study demonstrates the significant reduction of skin toxicity after Ne MBRT irradiation compared to conventional Ne irradiation, which may open up possibilities for the renewed use of heavy ions in cancer therapy.
Article
Multidisciplinary Sciences
Katsutoshi Sato, Amol A. Padgaonkar, Stacey J. Baker, Stephen C. Cosenza, Olga Rechkoblit, D. R. C. Venkata Subbaiah, Josep Domingo-Domenech, Alison Bartkowski, Elisa R. Port, Aneel K. Aggarwal, M. V. Ramana Reddy, Hanna Y. Irie, E. Premkumar Reddy
Summary: Finding therapeutic strategies for aggressive triple negative breast cancer (TNBC) is an important challenge in clinical practice. Here, the authors identify a multi-kinase inhibitor with antitumor activity and able overcome chemotherapy resistance of TNBC in vivo.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Lin Xie, Kuan Hu, Yanhong Duo, Takashi Shimokawa, Katsushi Kumata, Yiding Zhang, Cuiping Jiang, Lulu Zhang, Nobuki Nengaki, Hidekatsu Wakizaka, Yihai Cao, Ming-Rong Zhang
Summary: The study used a small-molecule radiotracer, C-11-l-1MTrp, to quantitatively and longitudinally visualize whole-body IDO1 dynamics, accurately delineating changes in the cancer-immune milieu and assessing the efficacy of multiple combinatorial immunotherapies. The results suggest that PET imaging of IDO1 with C-11-l-1MTrp can serve as a robust method for tracking IDO1 in therapeutic interventions, highlighting its potential as a new biomarker for personalized cancer immunotherapy strategies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Plant Sciences
Tomoya Hosoguchi, Yuna Uchiyama, Hinata Komazawa, Masaki Yahata, Takashi Shimokawa, Akiyoshi Tominaga
Summary: In this study, Gerbera in vitro shoots were irradiated with ion beams of different LETs to explore effective LET and absorbed doses for mutagenesis. It was found that ion beams with higher LETs had a lower LD50, and induced trait/morphological mutations in color, shape, and male fertility. The highest growth change and trait/morphological mutation rates were observed with C irradiation at 10 Gy, Ar irradiation at 5 Gy, and Fe irradiation at 5 Gy, with Ar irradiation at 5 Gy showing the highest mutation rate of 14.1%. Genomic mutations in flower color, petal shape, and male sterile mutants were confirmed using Genotyping by Random Amplicon Sequencing-Direct technology. These findings could lead to more efficient gerbera mutant production and analysis technology.
Article
Oncology
D. S. Prabakaran, Pankaj Kumar Chaturvedi, Takashi Shimokawa, Ki-Hwan Kim, Woo-Yoon Park
Summary: Silencing of FTS enhances the radiosensitivity of cervical cancer cells to Carbon ion radiation by downregulating Notch signaling molecules and decreasing the survival of cancer stem cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Liqiu Ma, Yoshimitsu Sakamoto, Ken Ando, Hidetoshi Fujita, Akihisa Takahashi, Tsuguhide Takeshima, Hiromi Otsuka, Daniel K. Ebner, Kazuhiro Kakimi, Takashi Imai, Takashi Shimokawa
Summary: The study aims to clarify the mechanisms of metastasis suppression by carbon-ion radiotherapy combined with immature dendritic cell immunotherapy (CiDC). CiDC was found to effectively suppress lung metastasis in mouse models, and the genetic background of the host may have an impact on the efficacy of combination therapy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Biotechnology & Applied Microbiology
Takuya Noguchi, Ryuji Nishiyama, Takashi Shimokawa, Katsushige Yamada, Yusuke Kagawa
Summary: This study isolated a mutant strain of Trichoderma reesei lacking β-glucosidase and β-xylosidase activities, resulting in high yields and ratios of cellobiose and xylobiose during the hydrolysis of alkalitreated bagasse.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2022)
Meeting Abstract
Oncology
Takashi Shimokawa, Takamitsu Morioka
Meeting Abstract
Cardiac & Cardiovascular Systems
Nozomi Furukawa, Naoko Okano, Yukari Yoshida, Takashi Shimokawa, Akinori Kanai, Tatsuya Ohno, Norimichi Koitabashi