Cerium Oxide Nanoparticles Rescue α-Synuclein-Induced Toxicity in a Yeast Model of Parkinson’s Disease

α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling

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A traffic jam leads to Lewy bodies

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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

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Cerium oxide NPs mitigate the amyloid formation of α-synuclein and associated cytotoxicity

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Parkinson’s disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein

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Custom-Made Ceria Nanoparticles Show a Neuroprotective Effect by Modulating Phenotypic Polarization of the Microglia

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Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration

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Not Only Redox: The Multifaceted Activity of Cerium Oxide Nanoparticles in Cancer Prevention and Therapy

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Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

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Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

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Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

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Efficacy of Different Compositions of Cerium Oxide Nanoparticles in Tumor-Stroma Interaction

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Cerium oxide nanoparticles could ameliorate behavioral and neurochemical impairments in 6-hydroxydopamine induced Parkinson's disease in rats

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Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

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Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways

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Protein misfolding in neurodegenerative diseases: implications and strategies

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Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer’s Disease

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Silica nanoparticles induce alpha-synuclein induction and aggregation in PC12-cells

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How to bake a brain: yeast as a model neuron

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Flow Cytometry-Based Assessment of Mitophagy Using MitoTracker

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Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

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Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity

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Flow cytometry for intracellular SPION quantification: specificity and sensitivity in comparison with spectroscopic methods

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Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

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Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells

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Untangling the biological effects of cerium oxide nanoparticles: the role of surface valence states

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Catalytic properties and biomedical applications of cerium oxide nanoparticles

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Cerium Oxide Nanoparticles Induce Oxidative Stress and Genotoxicity in Human Skin Melanoma Cells

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Cerium oxide nanoparticles protect against Aβ-induced mitochondrial fragmentation and neuronal cell death

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Combination of Conventional Chemotherapeutics with Redox-Active Cerium Oxide Nanoparticles--A Novel Aspect in Cancer Therapy

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From yeast to patient neurons and back again: Powerful new discovery platforms

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Calcineurin determines toxic versus beneficial responses to  -synuclein

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Cerium oxide nanoparticles in cancer

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Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

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Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation

(2014) Luis Fonseca-Ornelas et al.   Nature Communications

Effects of titanium dioxide nanoparticles on α-synuclein aggregation and the ubiquitin-proteasome system in dopaminergic neurons

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Custom Cerium Oxide Nanoparticles Protect against a Free Radical Mediated Autoimmune Degenerative Disease in the Brain

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Transcriptional profile of genes involved in oxidative stress and antioxidant defense in PC12 cells following treatment with cerium oxide nanoparticles

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Detection of silver nanoparticles in cells by flow cytometry using light scatter and far-red fluorescence

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Influence of Gold Nanoparticles on the Kinetics of α-Synuclein Aggregation

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Effects of Cerium Oxide Nanoparticles on PC12 Neuronal-Like Cells: Proliferation, Differentiation, and Dopamine Secretion

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Nanoceria: A Rare-Earth Nanoparticle as a Novel Anti-Angiogenic Therapeutic Agent in Ovarian Cancer

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Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

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Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

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Cerium oxide nanoparticles induce cytotoxicity in human hepatoma SMMC-7721 cells via oxidative stress and the activation of MAPK signaling pathways

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A simple colony-formation assay in liquid medium, termed ‘tadpoling’, provides a sensitive measure ofSaccharomyces cerevisiaeculture viability

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SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy

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Cerium oxide nanoparticles scavenge nitric oxide radical (˙NO)

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Flow Cytometric Evaluation of Nanoparticles Using Side-Scattered Light and Reactive Oxygen Species-Mediated Fluorescence–Correlation with Genotoxicity

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Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

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Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform

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Nano-CeO2Exhibits Adverse Effects at Environmental Relevant Concentrations

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Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia

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Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms

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Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

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Pharmacological potential of cerium oxide nanoparticles

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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

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In vivo demonstration that  -synuclein oligomers are toxic

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Surface-Charge-Dependent Cell Localization and Cytotoxicity of Cerium Oxide Nanoparticles

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α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

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Nanoceria exhibit redox state-dependent catalase mimetic activity

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Cerium oxide nanoparticles protect gastrointestinal epithelium from radiation-induced damage by reduction of reactive oxygen species and upregulation of superoxide dismutase 2

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Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles

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Cerium Oxide Nanoparticles Trigger Neuronal Survival in a Human Alzheimer Disease Model By Modulating BDNF Pathway

(2009) Barbara D'Angelo et al.   Current Nanoscience

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

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Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

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Rapid selection of cyclic peptides that reduce α-synuclein toxicity in yeast and animal models

(2009) Joshua A Kritzer et al.   Nature Chemical Biology

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

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Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

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The role of cerium redox state in the SOD mimetic activity of nanoceria

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Hazard and Risk Assessment of a Nanoparticulate Cerium Oxide-Based Diesel Fuel Additive—A Case Study

(2008) Barry Park et al.   INHALATION TOXICOLOGY

Functional Mitochondria Are Required for α-Synuclein Toxicity in Aging Yeast

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α-Synuclein–induced Aggregation of Cytoplasmic Vesicles in Saccharomyces cerevisiae

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