Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Structural basis of synaptic vesicle assembly promoted by α-synuclein

(2016) Giuliana Fusco et al.   Nature Communications

Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein

(2016) Marija Iljina et al.   Scientific Reports

Definition of a Molecular Pathway Mediating  -Synuclein Neurotoxicity

(2015) J. Burre et al.   JOURNAL OF NEUROSCIENCE

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity

(2015) Ulf Dettmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

(2015) Ulf Dettmer et al.   Nature Communications

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

(2014) Lina Wang et al.   CURRENT BIOLOGY

Evidence of Native α-Synuclein Conformers in the Human Brain

(2014) Neal Gould et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis

(2014) K. J. Vargas et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation

(2014) Luis Fonseca-Ornelas et al.   Nature Communications

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?

(2013) Aoife P. Kiely et al.   ACTA NEUROPATHOLOGICA

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Membrane bound α-synuclein is fully embedded in the lipid bilayer while segments with higher flexibility remain

(2013) Jonas Wietek et al.   FEBS LETTERS

In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells

(2013) Ulf Dettmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dynamic Structure of α-Synuclein Multimers

(2013) Thomas Gurry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

Properties of native brain α-synuclein

(2013) Jacqueline Burré et al.   NATURE

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

A New Method for Quantitative Immunoblotting of Endogenous α-Synuclein

(2013) Andrew J. Newman et al.   PLoS One

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

(2013) C. Y. Chung et al.   SCIENCE

Monomeric Synucleins Generate Membrane Curvature

(2012) Christopher H. Westphal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding

(2011) Iwona M. Pranke et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia

(2010) Walter J. Schulz-Schaeffer   ACTA NEUROPATHOLOGICA

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Curvature Dynamics of α-Synuclein Familial Parkinson Disease Mutants

(2009) Jason D. Perlmutter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein–induced Aggregation of Cytoplasmic Vesicles in Saccharomyces cerevisiae

(2008) James H. Soper et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of membrane-bound  -synuclein from site-directed spin labeling and computational refinement

(2008) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain

(2007) Julia Fuchs et al.   FASEB JOURNAL