The Roles of the NLRP3 Inflammasome in Neurodegenerative and Metabolic Diseases and in Relevant Advanced Therapeutic Interventions
出版年份 2020 全文链接
标题
The Roles of the NLRP3 Inflammasome in Neurodegenerative and Metabolic Diseases and in Relevant Advanced Therapeutic Interventions
作者
关键词
-
出版物
Genes
Volume 11, Issue 2, Pages 131
出版商
MDPI AG
发表日期
2020-01-28
DOI
10.3390/genes11020131
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- MoDeSuS: A Machine Learning Tool for Selection of Molecular Descriptors in QSAR Studies Applied to Molecular Informatics
- (2019) María Jimena Martínez et al. Biomed Research International
- Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
- (2019) Yang Yang et al. Cell Death & Disease
- Convolutional neural network for cell classification using microscope images of intracellular actin networks
- (2019) Ronald Wihal Oei et al. PLoS One
- Accurate Prediction of Biological Assays with High-Throughput Microscopy Images and Convolutional Networks
- (2019) Markus Hofmarcher et al. Journal of Chemical Information and Modeling
- Predicting the cytotoxicity of chemicals using ensemble learning methods and molecular fingerprints
- (2019) Zimo Yin et al. JOURNAL OF APPLIED TOXICOLOGY
- Islet inflammation in type 2 diabetes
- (2019) Marianne Böni-Schnetzler et al. Seminars in Immunopathology
- NLRP3 inflammasome
- (2019) Marina Sokolova et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity
- (2019) Marina Sokolova et al. Frontiers in Immunology
- Neuroinflammation in Alzheimer’s Disease: Microglia, Molecular Participants and Therapeutic Choices
- (2019) Haijun Wang et al. Current Alzheimer Research
- Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
- (2019) Alessandra Cadete Martini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Trends in incidence of total or type 2 diabetes: systematic review
- (2019) Dianna J Magliano et al. BMJ-British Medical Journal
- Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model
- (2019) Jing-Wei Liang et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer’s Disease
- (2018) Kedar Batkulwar et al. ACS Chemical Neuroscience
- Quantum Machine Learning in Chemical Compound Space
- (2018) O. Anatole von Lilienfeld ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Adipokines and inflammation: is it a question of weight?
- (2018) Vera Francisco et al. BRITISH JOURNAL OF PHARMACOLOGY
- The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways
- (2018) Danlu Jiang et al. CANCER LETTERS
- Gain of function mutation and inflammasome driven diseases in human and mouse models
- (2018) Mario D. Cordero et al. JOURNAL OF AUTOIMMUNITY
- Opportunities and obstacles for deep learning in biology and medicine
- (2018) Travers Ching et al. Journal of the Royal Society Interface
- Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review
- (2018) Yue Lang et al. MEDIATORS OF INFLAMMATION
- NLRP1 and NLRP3 inflammasomes mediate LPS/ATP‑induced pyroptosis in knee osteoarthritis
- (2018) Ling‑Rui Zhao et al. Molecular Medicine Reports
- Targeting the NLRP3 inflammasome in inflammatory diseases
- (2018) Matthew S. J. Mangan et al. NATURE REVIEWS DRUG DISCOVERY
- Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids
- (2018) Marcelo Rogero et al. Nutrients
- A role for tau in learning, memory and synaptic plasticity
- (2018) Fabrizio Biundo et al. Scientific Reports
- DPubChem: a web tool for QSAR modeling and high-throughput virtual screening
- (2018) Othman Soufan et al. Scientific Reports
- Representability of algebraic topology for biomolecules in machine learning based scoring and virtual screening
- (2018) Zixuan Cang et al. PLoS Computational Biology
- Intelligent Image-Activated Cell Sorting
- (2018) Nao Nitta et al. CELL
- Deep reinforcement learning for de novo drug design
- (2018) Mariya Popova et al. Science Advances
- Machine Learning-based Virtual Screening and Its Applications to Alzheimer’s Drug Discovery: A Review
- (2018) Kristy A. Carpenter et al. CURRENT PHARMACEUTICAL DESIGN
- Less Exploited GPCRs in Precision Medicine: Targets for Molecular Imaging and Theranostics
- (2018) João Franco Machado et al. MOLECULES
- T Cells in Adipose Tissue: Critical Players in Immunometabolism
- (2018) Qun Wang et al. Frontiers in Immunology
- Advances in omics for informed pharmaceutical research and development in the era of systems medicine
- (2017) Jane P. F. Bai et al. Expert Opinion on Drug Discovery
- Mechanisms governing inflammasome activation, assembly and pyroptosis induction
- (2017) Sannula Kesavardhana et al. INTERNATIONAL IMMUNOLOGY
- Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders
- (2017) Hua Jiang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome
- (2017) Viola Neudecker et al. JOURNAL OF EXPERIMENTAL MEDICINE
- NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain
- (2017) Andrea Stutz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Multiple machine learning based descriptive and predictive workflow for the identification of potential PTP1B inhibitors
- (2017) Sharat Chandra et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Macrophage functions in lean and obese adipose tissue
- (2017) Dylan Thomas et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review
- (2017) Jakeline Rheinheimer et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- MicroRNA‑33 regulates the NLRP3 inflammasome signaling pathway in macrophages
- (2017) Qingyun Xie et al. Molecular Medicine Reports
- NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease
- (2017) Jun Yin et al. MOLECULAR NEUROBIOLOGY
- Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease
- (2017) Carmen Venegas et al. NATURE
- Amelioration of amyloid β-induced retinal inflammatory responses by a LXR agonist TO901317 is associated with inhibition of the NF-κB signaling and NLRP3 inflammasome
- (2017) Chunyan Lei et al. NEUROSCIENCE
- Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
- (2017) Jianjin Shi et al. TRENDS IN BIOCHEMICAL SCIENCES
- Inflammasome Priming in Sterile Inflammatory Disease
- (2017) Meghana N. Patel et al. TRENDS IN MOLECULAR MEDICINE
- Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening and in vitro biological activities study
- (2017) Hongbo Xie et al. Oncotarget
- Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes
- (2017) Lingling Chen et al. Oncotarget
- Late-Onset Cryopyrin-Associated Periodic Syndromes Caused by Somatic NLRP3 Mosaicism—UK Single Center Experience
- (2017) Dorota M. Rowczenio et al. Frontiers in Immunology
- Prediction of Organic Reaction Outcomes Using Machine Learning
- (2017) Connor W. Coley et al. ACS Central Science
- Optimizing Chemical Reactions with Deep Reinforcement Learning
- (2017) Zhenpeng Zhou et al. ACS Central Science
- Inflammasome Complexes: Emerging Mechanisms and Effector Functions
- (2016) Vijay A.K. Rathinam et al. CELL
- AutoQSAR: an automated machine learning tool for best-practice quantitative structure–activity relationship modeling
- (2016) Steven L Dixon et al. Future Medicinal Chemistry
- Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome
- (2016) Chuansheng Guo et al. IMMUNITY
- NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
- (2016) Marianne R. Spalinger et al. JOURNAL OF CLINICAL INVESTIGATION
- Pore-forming activity and structural autoinhibition of the gasdermin family
- (2016) Jingjin Ding et al. NATURE
- NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
- (2016) Yuan He et al. NATURE
- Mechanisms of Aβ Clearance and Degradation by Glial Cells
- (2016) Miriam Ries et al. Frontiers in Aging Neuroscience
- Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis
- (2015) Sachiko Bando et al. ATHEROSCLEROSIS
- A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents
- (2015) Romy Kursawe et al. DIABETES
- Miro1-mediated mitochondrial dysfunction under high nutrient stress is linked to NOD-like receptor 3 (NLRP3)-dependent inflammatory responses in rat pancreatic beta cells
- (2015) Jianfeng Gao et al. FREE RADICAL BIOLOGY AND MEDICINE
- The inflammasome: firing up innate immunity
- (2015) Thirumala-Devi Kanneganti IMMUNOLOGICAL REVIEWS
- Comparative Modeling and Benchmarking Data Sets for Human Histone Deacetylases and Sirtuin Families
- (2015) Jie Xia et al. Journal of Chemical Information and Modeling
- The pathogenic role of the inflammasome in neurodegenerative diseases
- (2015) Leslie C. Freeman et al. JOURNAL OF NEUROCHEMISTRY
- Predicting selective liver X receptor β agonists using multiple machine learning methods
- (2015) Yali Li et al. Molecular BioSystems
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
- (2015) Yun-Hee Youm et al. NATURE MEDICINE
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats
- (2015) Andreea Oana Mocanu et al. PLoS One
- MLViS: A Web Tool for Machine Learning-Based Virtual Screening in Early-Phase of Drug Discovery and Development
- (2015) Selcuk Korkmaz et al. PLoS One
- Apelin inhibits the activation of the nucleotide-binding domain and the leucine-rich, repeat-containing family, pyrin-containing 3 (NLRP3) inflammasome and ameliorates insulin resistance in severely burned rats
- (2015) Yunfei Chi et al. SURGERY
- Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway
- (2015) Xukai Wang et al. Scientific Reports
- Mechanisms and Functions of Inflammasomes
- (2014) Mohamed Lamkanfi et al. CELL
- Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity
- (2014) Prabhakara R. Nagareddy et al. Cell Metabolism
- Mitochondrial response to nutrient availability and its role in metabolic disease
- (2014) A. W. Gao et al. EMBO Molecular Medicine
- Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2
- (2014) N. Marina-Garcia et al. JOURNAL OF IMMUNOLOGY
- Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+Efflux
- (2014) Luigi Franchi et al. JOURNAL OF IMMUNOLOGY
- Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation
- (2014) Hiroe Honda et al. JOURNAL OF LEUKOCYTE BIOLOGY
- NRLiSt BDB, the Manually Curated Nuclear Receptors Ligands and Structures Benchmarking Database
- (2014) Nathalie Lagarde et al. JOURNAL OF MEDICINAL CHEMISTRY
- Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation
- (2014) Zheng Yin et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
- (2014) Alberto Baroja-Mazo et al. NATURE IMMUNOLOGY
- Oridonin Attenuates Aβ1–42-Induced Neuroinflammation and Inhibits NF-κB Pathway
- (2014) Sulei Wang et al. PLoS One
- Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases
- (2014) Eiji Yoshihara et al. Frontiers in Immunology
- Inflammasomes and Metabolic Disease
- (2013) Jorge Henao-Mejia et al. Annual Review of Physiology
- Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue
- (2013) Nathalie Esser et al. DIABETOLOGIA
- Evaluation and Optimization of Virtual Screening Workflows with DEKOIS 2.0 – A Public Library of Challenging Docking Benchmark Sets
- (2013) Matthias R. Bauer et al. Journal of Chemical Information and Modeling
- CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
- (2013) Frederick J Sheedy et al. NATURE IMMUNOLOGY
- Inflammasomes and Their Roles in Health and Disease
- (2012) Mohamed Lamkanfi et al. Annual Review of Cell and Developmental Biology
- Recognition of Bacteria by Inflammasomes
- (2012) Jakob von Moltke et al. Annual Review of Immunology
- The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain
- (2012) Megan M. Varnum et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- DoGSiteScorer: a web server for automatic binding site prediction, analysis and druggability assessment
- (2012) A. Volkamer et al. BIOINFORMATICS
- The Inflammasome Puts Obesity in the Danger Zone
- (2012) Rinke Stienstra et al. Cell Metabolism
- Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial
- (2012) A. Rissanen et al. DIABETES OBESITY & METABOLISM
- Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
- (2012) Kenichi Shimada et al. IMMUNITY
- Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation
- (2012) Christine Juliana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking
- (2012) Michael M. Mysinger et al. JOURNAL OF MEDICINAL CHEMISTRY
- Novel crosstalk between ERK MAPK and p38 MAPK leads to homocysteine-NMDA receptor-mediated neuronal cell death
- (2012) Ranjana Poddar et al. JOURNAL OF NEUROCHEMISTRY
- Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
- (2012) Bénédicte F. Py et al. MOLECULAR CELL
- Inflammasomes in health and disease
- (2012) Till Strowig et al. NATURE
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- Immunological complications of obesity
- (2012) Thirumala-Devi Kanneganti et al. NATURE IMMUNOLOGY
- Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
- (2012) Saswata Talukdar et al. NATURE MEDICINE
- Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
- (2012) Manuela Rossol et al. Nature Communications
- Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet-Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis
- (2011) F. C. McGillicuddy et al. DIABETES
- NNScore 2.0: A Neural-Network Receptor–Ligand Scoring Function
- (2011) Jacob D. Durrant et al. Journal of Chemical Information and Modeling
- Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?
- (2011) Robert H. Eckel et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome
- (2011) F. Bauernfeind et al. JOURNAL OF IMMUNOLOGY
- Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal -Catenin Pathway Function in an Alzheimer's Disease Model
- (2011) M. Kitazawa et al. JOURNAL OF IMMUNOLOGY
- An active role for machine learning in drug development
- (2011) Robert F Murphy Nature Chemical Biology
- Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
- (2011) Haitao Wen et al. NATURE IMMUNOLOGY
- The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
- (2011) Bolormaa Vandanmagsar et al. NATURE MEDICINE
- Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
- (2011) Marco Prinz et al. NATURE NEUROSCIENCE
- ChEMBL: a large-scale bioactivity database for drug discovery
- (2011) A. Gaulton et al. NUCLEIC ACIDS RESEARCH
- Inflammasome is a central player in the induction of obesity and insulin resistance
- (2011) R. Stienstra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of IL-1β in type 2 diabetes
- (2011) Charles A Dinarello et al. Current Opinion in Endocrinology Diabetes and Obesity
- Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?
- (2010) Kawser Akter et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Mechanisms Underlying Inflammation in Neurodegeneration
- (2010) Christopher K. Glass et al. CELL
- Pattern Recognition Receptors and Inflammation
- (2010) Osamu Takeuchi et al. CELL
- Critical functions of priming and lysosomal damage for NLRP3 activation
- (2010) Veit Hornung et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Ranking Chemical Structures for Drug Discovery: A New Machine Learning Approach
- (2010) Shivani Agarwal et al. Journal of Chemical Information and Modeling
- StructRank: A New Approach for Ligand-Based Virtual Screening
- (2010) Fabian Rathke et al. Journal of Chemical Information and Modeling
- Molecular Mechanism of NLRP3 Inflammasome Activation
- (2010) Chengcheng Jin et al. JOURNAL OF CLINICAL IMMUNOLOGY
- A role for mitochondria in NLRP3 inflammasome activation
- (2010) Rongbin Zhou et al. NATURE
- Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
- (2010) Seth L Masters et al. NATURE IMMUNOLOGY
- Neuroimmunomodulation in the Pathogenesis of Alzheimer’s Disease
- (2010) Inelia Morales et al. NEUROIMMUNOMODULATION
- In-Silico Approaches to Multi-target Drug Discovery
- (2010) Xiao Hua Ma et al. PHARMACEUTICAL RESEARCH
- Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A deposition in an Alzheimer mouse model with diabetes
- (2010) S. Takeda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The NLRP3 Inflammasome: A Sensor for Metabolic Danger?
- (2010) K. Schroder et al. SCIENCE
- Toll-like receptors: linking inflammation to metabolism
- (2010) A. Christine Könner et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The Role of Neuroimmunomodulation in Alzheimer's Disease
- (2009) Ricardo B. Maccioni et al. Annals of the New York Academy of Sciences
- Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice
- (2009) Corinne G. Jolivalt et al. EXPERIMENTAL NEUROLOGY
- Searching for Target-Selective Compounds Using Different Combinations of Multiclass Support Vector Machine Ranking Methods, Kernel Functions, and Fingerprint Descriptors
- (2009) Anne Mai Wassermann et al. Journal of Chemical Information and Modeling
- Thioredoxin-interacting protein links oxidative stress to inflammasome activation
- (2009) Rongbin Zhou et al. NATURE IMMUNOLOGY
- CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
- (2009) Satoshi Nishimura et al. NATURE MEDICINE
- Molecular mechanisms involved in inflammasome activation
- (2009) Clare Bryant et al. TRENDS IN CELL BIOLOGY
- Predicting small ligand binding sites in proteins using backbone structure
- (2008) Andrew J. Bordner BIOINFORMATICS
- Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet
- (2008) Andréa M Caricilli et al. JOURNAL OF ENDOCRINOLOGY
- Microglial Dysfunction and Defective -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
- (2008) S. E. Hickman et al. JOURNAL OF NEUROSCIENCE
- Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease
- (2008) Melanie Meyer-Luehmann et al. NATURE
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
- (2008) Annett Halle et al. NATURE IMMUNOLOGY
- Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients
- (2007) Johanna Ojala et al. NEUROBIOLOGY OF AGING
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