Luteolin activates ERK1/2- and Ca2+-dependent HO-1 induction that reduces LPS-induced HMGB1, iNOS/NO, and COX-2 expression in RAW264.7 cells and mitigates acute lung injury of endotoxin mice

Hydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release

(2017) Yang Yu et al.   SHOCK

Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response

(2017) Yung-Li Hung et al.   Scientific Reports

Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes

(2017) Natalie E. Stevens et al.   Scientific Reports

Luteolin inhibits viral-induced inflammatory response in RAW264.7 cells via suppression of STAT1/3 dependent NF-κB and activation of HO-1

(2016) Cheng-Wei Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects

(2016) Jie Xiong et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin

(2015) Ximena Paredes-Gonzalez et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo

(2015) Wonhwa Lee et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells

(2015) Pei-Shan Wu et al.   PLoS One

Transient Receptor Potential Melastatin 2 Protects Mice against Polymicrobial Sepsis by Enhancing Bacterial Clearance

(2014) XiaoWei Qian et al.   ANESTHESIOLOGY

Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation

(2014) Barbara Wegiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions

(2012) M. Kashio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress suppression by luteolin-induced heme oxygenase-1 expression

(2012) Gui-bo Sun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control

(2011) Daolin Tang et al.   Cell Metabolism

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

(2011) Anke Di et al.   NATURE IMMUNOLOGY

Stimulation of Alpha7 Nicotinic Acetylcholine Receptor by Nicotine Attenuates Inflammatory Response in Macrophages and Improves Survival in Experimental Model of Sepsis Through Heme Oxygenase-1 Induction

(2010) Konstantin Tsoyi et al.   ANTIOXIDANTS & REDOX SIGNALING

Transient Receptor Potential Melastatin 2 Is Required for Lipopolysaccharide-Induced Cytokine Production in Human Monocytes

(2010) Janine Wehrhahn et al.   JOURNAL OF IMMUNOLOGY

Carbon Monoxide From CORM-2 Reduces HMGB1 Release Through Regulation of IFN-β/JAK2/STAT-1/INOS/NO Signaling But Not COX-2 in TLR-Activated Macrophages

(2010) Konstantin Tsoyi et al.   SHOCK

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

(2008) Shinichiro Yamamoto et al.   NATURE MEDICINE