Triptolide Preserves Cognitive Function and Reduces Neuropathology in a Mouse Model of Alzheimer's Disease

Changes in the brain and plasma Aβ peptide levels with age and its relationship with cognitive impairment in the APPswe/PS1dE9 mouse model of Alzheimer’s disease

(2014) M. Izco et al.   NEUROSCIENCE

Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease

(2013) Shaowu Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Turnover of C99 is Controlled by a Crosstalk between ERAD and Ubiquitin-Independent Lysosomal Degradation in Human Neuroglioma Cells

(2013) Hianara A. Bustamante et al.   PLoS One

Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II

(2012) S. G. Manzo et al.   CANCER RESEARCH

Microglia and Inflammation in Alzheimers Disease

(2012) Shweta Mandrekar-Colucci et al.   CNS & Neurological Disorders-Drug Targets

Triptolide with Potential Medicinal Value for Diseases of the Central Nervous System

(2012) Yan Zheng et al.   CNS Neuroscience & Therapeutics

Effects of triptolide on the synaptophysin expression of hippocampal neurons in the AD cellular model

(2012) Jing Nie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nitric Oxide Decreases the Enzymatic Activity of Insulin Degrading Enzyme in APP/PS1 Mice

(2012) Markus P. Kummer et al.   Journal of Neuroimmune Pharmacology

A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer

(2012) R. Chugh et al.   Science Translational Medicine

A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway

(2011) Yuan Tian et al.   FASEB JOURNAL

Triptolide and its expanding multiple pharmacological functions

(2011) Qiuyan Liu   INTERNATIONAL IMMUNOPHARMACOLOGY

XPB, a subunit of TFIIH, is a target of the natural product triptolide

(2011) Denis V Titov et al.   Nature Chemical Biology

Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates Neuroinflammation and Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer Disease

(2010) Terry L. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of the expression of inducible nitric oxide synthase

(2010) Andrea Pautz et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation

(2009) Sebastian Jäger et al.   JOURNAL OF NEUROCHEMISTRY

Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-κB/IκBα transcriptional complex

(2009) Pablo Kizelsztein et al.   JOURNAL OF NEUROIMMUNOLOGY

Triptolide inhibits COX-2 expression and PGE2release by suppressing the activity of NF-κB and JNK in LPS-treated microglia

(2008) Yuntao Gong et al.   JOURNAL OF NEUROCHEMISTRY

Triptolide inhibits amyloid-β1-42-induced TNF-α and IL-1β production in cultured rat microglia

(2008) Jian Jiao et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Triptolide protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats: Implication for immunosuppressive therapy in Parkinson’s disease

(2008) Jun-Peng Gao et al.   Neuroscience Bulletin