Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variants

Local structural unfolding at the edge-strands of beta sheets is the molecular basis for instability and aggregation of G85R and G93A mutants of superoxide dismutase 1

(2019) Debasish Kumar Ghosh et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Identification and structural characterization of deleterious non-synonymous single nucleotide polymorphisms in the human SKP2 gene

(2019) S.M. Zahid Hosen et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Molecular insights of the G2019S substitution in LRRK2 kinase domain associated with Parkinson's disease: A molecular dynamics simulation approach

(2019) Ashish Kumar Agrahari et al.   JOURNAL OF THEORETICAL BIOLOGY

Delineating the effect of mutations on the conformational dynamics of N-terminal domain of TDP-43

(2019) Vijay Kumar et al.   BIOPHYSICAL CHEMISTRY

Rare Angiogenin and Ribonuclease 4 variants associated with amyotrophic lateral sclerosis exhibit loss-of-function: a comprehensive in silico study

(2019) Aditya K. Padhi et al.   METABOLIC BRAIN DISEASE

Molecular basis for the loss-of-function effects of the Alzheimer’s disease–associated R47H variant of the immune receptor TREM2

(2018) Athena Sudom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural dynamics and quantum mechanical aspects of shikonin derivatives as CREBBP bromodomain inhibitors

(2018) Sarmistha Mitra et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

A Computational workflow for the identification of the potent inhibitor of type II secretion system traffic ATPase of Pseudomonas aeruginosa

(2018) Md. Arifuzzaman et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Insights into the role of d -amino acid oxidase mutations in amyotrophic lateral sclerosis

(2018) Aditya K. Padhi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Molecular Dynamics Simulation for All

(2018) Scott A. Hollingsworth et al.   NEURON

A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature

(2017) Efthimios Dardiotis et al.   NEUROBIOLOGY OF AGING

Structure-Activity Relationship in TLR4 Mutations: Atomistic Molecular Dynamics Simulations and Residue Interaction Network Analysis

(2017) Muhammad Ayaz Anwar et al.   Scientific Reports

Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation

(2017) Shanshan Guan et al.   Scientific Reports

Detection of Side Chain Rearrangements Mediating the Motions of Transmembrane Helices in Molecular Dynamics Simulations of G Protein-Coupled Receptors

(2017) Zied Gaieb et al.   Computational and Structural Biotechnology Journal

TREMs in Alzheimer's disease: Genetic and clinical investigations

(2016) Jia Cheng et al.   CLINICA CHIMICA ACTA

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Perspective: Computer simulations of long time dynamics

(2016) Ron Elber   JOURNAL OF CHEMICAL PHYSICS

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice

(2016) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

(2016) Daniel L Kober et al.   eLife

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

(2015) Charles C. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of I30T and I30M substitution in MPZ gene associated with Dejerine–Sottas syndrome type B (DSSB): A molecular modeling and dynamics

(2015) Ashish Agrahari et al.   JOURNAL OF THEORETICAL BIOLOGY

Investigation of Inhibition Mechanism of Chemokine Receptor CCR5 by Micro-second Molecular Dynamics Simulations

(2015) Ramin Ekhteiari Salmas et al.   Scientific Reports

Coding variants in TREM2 increase risk for Alzheimer's disease

(2014) Sheng Chih Jin et al.   HUMAN MOLECULAR GENETICS

Energy landscapes of functional proteins are inherently risky

(2014) Anne Gershenson et al.   Nature Chemical Biology

Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes

(2014) Mathias Thelen et al.   NEUROBIOLOGY OF AGING

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

Evidence of Trem2 Variant Associated with Triple Risk of Alzheimer’s Disease

(2014) Zainularifeen Abduljaleel et al.   PLoS One

Dissecting the Critical Factors for Thermodynamic Stability of Modular Proteins Using Molecular Modeling Approach

(2014) Yuno Lee et al.   PLoS One

Computational approaches to understanding protein aggregation in neurodegeneration

(2014) R. L. Redler et al.   Journal of Molecular Cell Biology

IntegratingIn SilicoPrediction Methods, Molecular Docking, and Molecular Dynamics Simulation to Predict the Impact of ALK Missense Mutations in Structural Perspective

(2014) C. George Priya Doss et al.   Biomed Research International

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

(2013) Rita Guerreiro et al.   NEUROBIOLOGY OF AGING

Prediction of Functional Loss of Human Angiogenin Mutants Associated with ALS by Molecular Dynamics Simulations

(2013) Aditya K. Padhi et al.   Scientific Reports

Soluble expression of proteins correlates with a lack of positively-charged surface

(2013) Pedro Chan et al.   Scientific Reports

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

(2013) Rita João Guerreiro et al.   JAMA Neurology

Relaxation Estimation of RMSD in Molecular Dynamics Immunosimulations

(2012) Wolfgang Schreiner et al.   Computational and Mathematical Methods in Medicine

Folding of pig gastric mucin non-glycosylated domains: a discrete molecular dynamics study

(2012) Bogdan Barz et al.   JOURNAL OF BIOLOGICAL PHYSICS

Comparative structural analysis of two proteins belonging to quorum sensing system inVibrio cholerae

(2012) Mobashar Hussain Urf Turabe Fazil et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

A Comparison of Multiscale Methods for the Analysis of Molecular Dynamics Simulations

(2012) Noah C. Benson et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of Loss of Functions of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis

(2012) Aditya K. Padhi et al.   PLoS One

RING: networking interacting residues, evolutionary information and energetics in protein structures

(2011) A. J. M. Martin et al.   BIOINFORMATICS

Specific lipid recognition is a general feature of CD300 and TREM molecules

(2011) John P. Cannon et al.   IMMUNOGENETICS

Properties of liquid water from a systematic refinement of a high-rank multipolar electrostatic potential

(2010) Majeed S. Shaik et al.   JOURNAL OF CHEMICAL PHYSICS

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

ProPhylER: A curated online resource for protein function and structure based on evolutionary constraint analyses

(2009) J. Binkley et al.   GENOME RESEARCH