Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variants
出版年份 2020 全文链接
标题
Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variants
作者
关键词
-
出版物
Scientific Reports
Volume 10, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-02-27
DOI
10.1038/s41598-020-60561-x
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Local structural unfolding at the edge-strands of beta sheets is the molecular basis for instability and aggregation of G85R and G93A mutants of superoxide dismutase 1
- (2019) Debasish Kumar Ghosh et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Identification and structural characterization of deleterious non-synonymous single nucleotide polymorphisms in the human SKP2 gene
- (2019) S.M. Zahid Hosen et al. COMPUTATIONAL BIOLOGY AND CHEMISTRY
- Molecular insights of the G2019S substitution in LRRK2 kinase domain associated with Parkinson's disease: A molecular dynamics simulation approach
- (2019) Ashish Kumar Agrahari et al. JOURNAL OF THEORETICAL BIOLOGY
- Delineating the effect of mutations on the conformational dynamics of N-terminal domain of TDP-43
- (2019) Vijay Kumar et al. BIOPHYSICAL CHEMISTRY
- Rare Angiogenin and Ribonuclease 4 variants associated with amyotrophic lateral sclerosis exhibit loss-of-function: a comprehensive in silico study
- (2019) Aditya K. Padhi et al. METABOLIC BRAIN DISEASE
- Molecular basis for the loss-of-function effects of the Alzheimer’s disease–associated R47H variant of the immune receptor TREM2
- (2018) Athena Sudom et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural dynamics and quantum mechanical aspects of shikonin derivatives as CREBBP bromodomain inhibitors
- (2018) Sarmistha Mitra et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
- (2018) Yingjun Zhao et al. NEURON
- A Computational workflow for the identification of the potent inhibitor of type II secretion system traffic ATPase of Pseudomonas aeruginosa
- (2018) Md. Arifuzzaman et al. COMPUTATIONAL BIOLOGY AND CHEMISTRY
- Insights into the role of d -amino acid oxidase mutations in amyotrophic lateral sclerosis
- (2018) Aditya K. Padhi et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Molecular Dynamics Simulation for All
- (2018) Scott A. Hollingsworth et al. NEURON
- A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature
- (2017) Efthimios Dardiotis et al. NEUROBIOLOGY OF AGING
- Structure-Activity Relationship in TLR4 Mutations: Atomistic Molecular Dynamics Simulations and Residue Interaction Network Analysis
- (2017) Muhammad Ayaz Anwar et al. Scientific Reports
- Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation
- (2017) Shanshan Guan et al. Scientific Reports
- Detection of Side Chain Rearrangements Mediating the Motions of Transmembrane Helices in Molecular Dynamics Simulations of G Protein-Coupled Receptors
- (2017) Zied Gaieb et al. Computational and Structural Biotechnology Journal
- TREMs in Alzheimer's disease: Genetic and clinical investigations
- (2016) Jia Cheng et al. CLINICA CHIMICA ACTA
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Perspective: Computer simulations of long time dynamics
- (2016) Ron Elber JOURNAL OF CHEMICAL PHYSICS
- TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
- (2016) Yaming Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice
- (2016) Teng Jiang et al. MOLECULAR NEUROBIOLOGY
- TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
- (2016) Peng Yuan et al. NEURON
- TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
- (2016) Felix L. Yeh et al. NEURON
- Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
- (2016) Daniel L Kober et al. eLife
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
- (2015) Yuka Atagi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E
- (2015) Charles C. Bailey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TREM2 sustains microglial expansion during aging and response to demyelination
- (2015) Pietro Luigi Poliani et al. JOURNAL OF CLINICAL INVESTIGATION
- Impact of I30T and I30M substitution in MPZ gene associated with Dejerine–Sottas syndrome type B (DSSB): A molecular modeling and dynamics
- (2015) Ashish Agrahari et al. JOURNAL OF THEORETICAL BIOLOGY
- Investigation of Inhibition Mechanism of Chemokine Receptor CCR5 by Micro-second Molecular Dynamics Simulations
- (2015) Ramin Ekhteiari Salmas et al. Scientific Reports
- Coding variants in TREM2 increase risk for Alzheimer's disease
- (2014) Sheng Chih Jin et al. HUMAN MOLECULAR GENETICS
- Energy landscapes of functional proteins are inherently risky
- (2014) Anne Gershenson et al. Nature Chemical Biology
- Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes
- (2014) Mathias Thelen et al. NEUROBIOLOGY OF AGING
- Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease
- (2014) Teng Jiang et al. NEUROPSYCHOPHARMACOLOGY
- Evidence of Trem2 Variant Associated with Triple Risk of Alzheimer’s Disease
- (2014) Zainularifeen Abduljaleel et al. PLoS One
- Dissecting the Critical Factors for Thermodynamic Stability of Modular Proteins Using Molecular Modeling Approach
- (2014) Yuno Lee et al. PLoS One
- Computational approaches to understanding protein aggregation in neurodegeneration
- (2014) R. L. Redler et al. Journal of Molecular Cell Biology
- IntegratingIn SilicoPrediction Methods, Molecular Docking, and Molecular Dynamics Simulation to Predict the Impact of ALK Missense Mutations in Structural Perspective
- (2014) C. George Priya Doss et al. Biomed Research International
- Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
- (2013) Clifford R Jack et al. LANCET NEUROLOGY
- A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family
- (2013) Rita Guerreiro et al. NEUROBIOLOGY OF AGING
- Prediction of Functional Loss of Human Angiogenin Mutants Associated with ALS by Molecular Dynamics Simulations
- (2013) Aditya K. Padhi et al. Scientific Reports
- Soluble expression of proteins correlates with a lack of positively-charged surface
- (2013) Pedro Chan et al. Scientific Reports
- Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement
- (2013) Rita João Guerreiro et al. JAMA Neurology
- Relaxation Estimation of RMSD in Molecular Dynamics Immunosimulations
- (2012) Wolfgang Schreiner et al. Computational and Mathematical Methods in Medicine
- Folding of pig gastric mucin non-glycosylated domains: a discrete molecular dynamics study
- (2012) Bogdan Barz et al. JOURNAL OF BIOLOGICAL PHYSICS
- Comparative structural analysis of two proteins belonging to quorum sensing system inVibrio cholerae
- (2012) Mobashar Hussain Urf Turabe Fazil et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- A Comparison of Multiscale Methods for the Analysis of Molecular Dynamics Simulations
- (2012) Noah C. Benson et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mechanisms of Loss of Functions of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis
- (2012) Aditya K. Padhi et al. PLoS One
- RING: networking interacting residues, evolutionary information and energetics in protein structures
- (2011) A. J. M. Martin et al. BIOINFORMATICS
- Specific lipid recognition is a general feature of CD300 and TREM molecules
- (2011) John P. Cannon et al. IMMUNOGENETICS
- Properties of liquid water from a systematic refinement of a high-rank multipolar electrostatic potential
- (2010) Majeed S. Shaik et al. JOURNAL OF CHEMICAL PHYSICS
- TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1
- (2010) Q. Peng et al. Science Signaling
- ProPhylER: A curated online resource for protein function and structure based on evolutionary constraint analyses
- (2009) J. Binkley et al. GENOME RESEARCH
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