Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling

A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets

(2019) Nadav Sharon et al.   CELL

The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation

(2019) Heidrun Vethe et al.   Frontiers in Endocrinology

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

(2018) Anant Mamidi et al.   NATURE

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

(2018) Diego Balboa et al.   eLife

All mixed up: defining roles for β-cell subtypes in mature islets

(2017) Jennifer S.E. Liu et al.   GENES & DEVELOPMENT

δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin

(2017) L. J. B. Briant et al.   JOURNAL OF PHYSIOLOGY-LONDON

Current and Future Perspectives on Alginate Encapsulated Pancreatic Islet

(2017) Berit L. Strand et al.   Stem Cells Translational Medicine

Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation

(2017) Maja Borup Kjær Petersen et al.   Stem Cell Reports

Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells

(2017) Heidrun Vethe et al.   Scientific Reports

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds

(2016) James D. Johnson   DIABETOLOGIA

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Culture of hESC-derived pancreatic progenitors in alginate-based scaffolds

(2015) Kjetil Formo et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

MAFA and T3Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC

(2015) Cristina Aguayo-Mazzucato et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

(2015) Talitha van der Meulen et al.   NATURE MEDICINE

Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

(2015) Jennifer E. Bruin et al.   Stem Cell Reports

Neural control of the endocrine pancreas

(2014) Rayner Rodriguez-Diaz et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Stem Cells to Insulin Secreting Cells: Two Steps Forward and Now a Time to Pause?

(2014) Jake A. Kushner et al.   Cell Stem Cell

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

A comprehensive proteomic and phosphoproteomic analysis of yeast deletion mutants of 14-3-3 orthologs and associated effects of rapamycin

(2014) Joao A. Paulo et al.   PROTEOMICS

Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape

(2014) Kaitlyn Kirk et al.   Stem Cell Research

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

(2013) Jennifer E. Bruin et al.   DIABETOLOGIA

Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient

(2013) D. Jacobs-Tulleneers-Thevissen et al.   DIABETOLOGIA

Alginate microcapsule as a 3D platform for the efficient differentiation of human embryonic stem cells to dopamine neurons

(2013) Jaemin Kim et al.   Stem Cell Research

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

(2013) Jennifer E. Bruin et al.   Stem Cell Research

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells

(2012) Thomas C. Schulz et al.   PLoS One

Survival of human islets in microbeads containing high guluronic acid alginate crosslinked with Ca2+and Ba2+

(2012) Meirigeng Qi et al.   XENOTRANSPLANTATION

Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas

(2011) Rayner Rodriguez-Diaz et al.   Cell Metabolism

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells

(2011) C. L. Basford et al.   DIABETOLOGIA

Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat

(2011) S. E. Pinney et al.   DIABETOLOGIA

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

(2011) Olivia G Kelly et al.   NATURE BIOTECHNOLOGY

Function and Viability of Human Islets Encapsulated in Alginate Sheets: In Vitro and in Vivo Culture

(2011) M. Lamb et al.   TRANSPLANTATION PROCEEDINGS

Nkx6 Transcription Factors and Ptf1a Function as Antagonistic Lineage Determinants in Multipotent Pancreatic Progenitors

(2010) Ashleigh E. Schaffer et al.   DEVELOPMENTAL CELL

Production of Functional Glucagon-Secreting  -Cells From Human Embryonic Stem Cells

(2010) A. Rezania et al.   DIABETES

Beta cell coupling and connexin expression change during the functional maturation of rat pancreatic islets

(2010) C. P. F. Carvalho et al.   DIABETOLOGIA

Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm

(2009) Methichit Chayosumrit et al.   BIOMATERIALS

Human Islet Separation Utilizing a Closed Automated Purification System

(2009) A. S. Friberg et al.   CELL TRANSPLANTATION

The benefit of human embryonic stem cell encapsulation for prolonged feeder-free maintenance

(2008) Norhayati Siti-Ismail et al.   BIOMATERIALS

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY