The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers

Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model

(2019) Michal Wegrzynowicz et al.   ACTA NEUROPATHOLOGICA

Designed Macrocyclic Peptides as Nanomolar Amyloid Inhibitors Based on Minimal Recognition Elements

(2018) Anna Spanopoulou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP

(2018) Michele F.M. Sciacca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Time dependence of NMR observables reveals salient differences in the accumulation of early aggregated species between human islet amyloid polypeptide and amyloid-β

(2018) Anaïs R. F. Hoffmann et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Tanshinones inhibit hIAPP aggregation, disaggregate preformed hIAPP fibrils, and protect cultured cells

(2018) Baiping Ren et al.   Journal of Materials Chemistry B

Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

(2018) Antonio Heras-Garvin et al.   MOVEMENT DISORDERS

Synthesis and identification of novel pyridazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation

(2018) Syed Usama Bin Farrukh et al.   BIOORGANIC CHEMISTRY

A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP

(2017) Arnaldo L. Serrano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of proteolytically stable N-methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes

(2017) Idira Obasse et al.   Interface Focus

Sphingolipids and phospholipids in insulin resistance and related metabolic disorders

(2016) Peter J. Meikle et al.   Nature Reviews Endocrinology

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

(2016) Andisheh Abedini et al.   eLife

Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus

(2016) Lucie Caillon et al.   Journal of Diabetes Research

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

(2016) Rehana Akter et al.   Journal of Diabetes Research

Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives

(2016) Amit Pithadia et al.   Journal of Diabetes Research

Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy

(2016) Lisa Fellner et al.   Frontiers in Neuroscience

Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies

(2015) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates

(2015) Andreas A. Deeg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3

(2015) Shobhna Kapoor et al.   BIOPHYSICAL JOURNAL

What Can the Kinetics of Amyloid Fibril Formation Tell about Off-pathway Aggregation?

(2015) Rosa Crespo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset

(2014) Johannes Levin et al.   ACTA NEUROPATHOLOGICA

Obesity and Type 2 Diabetes in Children: Epidemiology and Treatment

(2014) Elizabeth R. Pulgaron et al.   Current Diabetes Reports

Defining the Molecular Basis of Amyloid Inhibitors: Human Islet Amyloid Polypeptide–Insulin Interactions

(2014) Anna C. Susa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of copper(ii) in the aggregation of human amylin

(2014) Alessandro Sinopoli et al.   Metallomics

Cholesterol modulates the interaction of the islet amyloid polypeptide with membranes

(2014) Lucie Caillon et al.   MOLECULAR MEMBRANE BIOLOGY

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

(2013) Sunil Kumar et al.   CHEMICAL COMMUNICATIONS

Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient  -sheet

(2013) L. E. Buchanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Amyloid Formation in Heterogeneous Environments: Islet Amyloid Polypeptide Glycosaminoglycan Interactions

(2012) Hui Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Coffee Components Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in Vitro: Possible Link between Coffee Consumption and Diabetes Mellitus

(2011) Biao Cheng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

(2011) Lei Chen et al.   Nature Reviews Endocrinology

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Epidemiology and Economic Impact of Obesity and Type 2 Diabetes

(2011) Hazem Shamseddeen et al.   SURGICAL CLINICS OF NORTH AMERICA

The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity

(2010) Marie Daval et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

The N-terminal fragment of human islet amyloid polypeptide is non-fibrillogenic in the presence of membranes and does not cause leakage of bilayers of physiologically relevant lipid composition

(2010) Lucie Khemtémourian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes

(2010) Lucie Khemtémourian et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

The Molecular Basis of Distinct Aggregation Pathways of Islet Amyloid Polypeptide

(2010) Lei Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

(2009) Ishu Saraogi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibiting Islet Amyloid Polypeptide Fibril Formation by the Red Wine Compound Resveratrol

(2009) Rajesh Mishra et al.   CHEMBIOCHEM

Small-Molecule Inhibitors of Islet Amyloid Polypeptide Fibril Formation

(2008) Rajesh Mishra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rifampicin Does Not Prevent Amyloid Fibril Formation by Human Islet Amyloid Polypeptide but Does Inhibit Fibril Thioflavin-T Interactions: Implications for Mechanistic Studies of β-Cell Death†

(2008) Fanling Meng et al.   BIOCHEMISTRY