Time dependence of NMR observables reveals salient differences in the accumulation of early aggregated species between human islet amyloid polypeptide and amyloid-β

A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP

(2017) Arnaldo L. Serrano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monomeric Aβ1–40 and Aβ1–42 Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil

(2016) Julien Roche et al.   BIOCHEMISTRY

An Account of Amyloid Oligomers: Facts and Figures Obtained from Experiments and Simulations

(2016) Luitgard Nagel-Steger et al.   CHEMBIOCHEM

Designed Glycopeptidomimetics Disrupt Protein–Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability

(2016) Julia Kaffy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membrane-bound tetramer and trimer Aβ oligomeric species correlate with toxicity towards cultured neurons

(2016) Metta K. Jana et al.   JOURNAL OF NEUROCHEMISTRY

Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus

(2016) Lucie Caillon et al.   Journal of Diabetes Research

Cross-Seeding Interaction between β-Amyloid and Human Islet Amyloid Polypeptide

(2015) Rundong Hu et al.   ACS Chemical Neuroscience

Solution NMR Studies of Recombinant Aβ(1-42): From the Presence of a Micellar Entity to Residual β-Sheet Structure in the Soluble Species

(2015) Marielle Aulikki Wälti et al.   CHEMBIOCHEM

Sample convection in liquid-state NMR: Why it is always with us, and what we can do about it

(2015) I. Swan et al.   JOURNAL OF MAGNETIC RESONANCE

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer´s disease: appealing for ESI-IM-MS

(2015) Rosa Pujol-Pina et al.   Scientific Reports

Cholesterol modulates the interaction of the islet amyloid polypeptide with membranes

(2014) Lucie Caillon et al.   MOLECULAR MEMBRANE BIOLOGY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of membrane models and their composition for islet amyloid polypeptide-membrane aggregation

(2013) Lucie Caillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

(2013) Lydia M. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient  -sheet

(2013) L. E. Buchanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ammonium hydroxide treatment of Aβ produces an aggregate free solution suitable for biophysical and cell culture characterization

(2013) Timothy M. Ryan et al.   PeerJ

Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F Nuclear Magnetic Resonance-Detected Kinetics of Monomer Consumption

(2012) Yuta Suzuki et al.   BIOCHEMISTRY

Enrichment of Amyloidogenesis at an Air-Water Interface

(2012) Létitia Jean et al.   BIOPHYSICAL JOURNAL

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Structural features and cytotoxicity of amyloid oligomers: Implications in Alzheimer's disease and other diseases with amyloid deposits

(2012) Massimo Stefani   PROGRESS IN NEUROBIOLOGY

Insight into Amyloid Structure Using Chemical Probes

(2011) Ashley A. Reinke et al.   Chemical Biology & Drug Design

Applications of saturation transfer difference NMR in biological systems

(2011) Anirban Bhunia et al.   DRUG DISCOVERY TODAY

Sugar-based peptidomimetics inhibit amyloid β-peptide aggregation

(2011) Bertrand Dorgeret et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR

(2011) Nicolas L. Fawzi et al.   NATURE

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Quantifying Prefibrillar Amyloids in vitro by Using a “Thioflavin-Like” Spectroscopic Method

(2010) Ashley A. Reinke et al.   CHEMBIOCHEM

The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes

(2010) Lucie Khemtémourian et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species

(2010) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics of Amyloid β Monomer-to-Oligomer Exchange by NMR Relaxation

(2010) Nicolas L. Fawzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stabilization of neurotoxic Alzheimer amyloid-  oligomers by protein engineering

(2010) A. Sandberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process

(2009) Erik Hellstrand et al.   ACS Chemical Neuroscience

Association of Highly Compact Type II Diabetes Related Islet Amyloid Polypeptide Intermediate Species at Physiological Temperature Revealed by Diffusion NMR Spectroscopy

(2009) Ronald Soong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sedimentation Studies on Human Amylin Fail to Detect Low-Molecular-Weight Oligomers

(2008) Sara M. Vaiana et al.   BIOPHYSICAL JOURNAL

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer

(2008) Rakez Kayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

(2008) M. F. M. Engel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid oligomers in diabetic and nondiabetic human pancreas

(2008) Hai-Lu Zhao et al.   Translational Research