Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects

From next generation sequencing to targeted treatment of non-acquired epilepsies

(2019) Rikke S Møller et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Epilepsy gene therapy using an engineered potassium channel

(2019) Albert Snowball et al.   JOURNAL OF NEUROSCIENCE

Extrasynaptic γ‐aminobutyric acid type A receptor–mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures

(2019) Doodipala Samba Reddy et al.   EPILEPSIA

A mouse model of seizures in anti-N -methyl-d -aspartate receptor encephalitis

(2019) Olga Taraschenko et al.   EPILEPSIA

Stiripentol for the treatment of seizures in Dravet syndrome

(2019) Krista Eschbach et al.   Expert Review of Clinical Pharmacology

Etiology is the key determinant of neuroinflammation in epilepsy: Elevation of cerebrospinal fluid cytokines and chemokines in febrile infection‐related epilepsy syndrome and febrile status epilepticus

(2019) Kavitha Kothur et al.   EPILEPSIA

Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters: An open‐label extension trial

(2019) James W. Wheless et al.   EPILEPSIA

Efficacy of antiepileptic drugs in the era of pharmacogenomics: A focus on childhood

(2019) Maria Gogou et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Elevation of plasma tRNA fragments precedes seizures in human epilepsy

(2019) Marion C. Hogg et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical features and long-term outcomes of seizures associated with autoimmune encephalitis: A follow-up study in East China

(2019) Lu Yao et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Comparison and Selection of Current Implantable Anti-Epileptic Devices

(2019) Stephen Wong et al.   Neurotherapeutics

From Clinical Trials to Clinical Practice: Practical Considerations for Gene Replacement Therapy in SMA Type 1

(2019) Samiah A. Al-Zaidy et al.   PEDIATRIC NEUROLOGY

Everolimus for the treatment of refractory seizures associated with tuberous sclerosis complex (TSC): current perspectives

(2019) IE Overwater et al.   Therapeutics and Clinical Risk Management

Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals

(2019) Yen-Chen Anne Feng et al.   AMERICAN JOURNAL OF HUMAN GENETICS

HPO-Shuffle: an associated gene prioritization strategy and its application in drug repurposing for the treatment of canine epilepsy

(2019) Shuguang Wang et al.   BIOSCIENCE REPORTS

Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy

(2019) Wenshu XiangWei et al.   BRAIN

Machine learning applications in epilepsy

(2019) Bardia Abbasi et al.   EPILEPSIA

The anesthetic drug treatment of refractory and super-refractory status epilepticus around the world: Results from a global audit

(2019) Monica Ferlisi et al.   EPILEPSY & BEHAVIOR

De novo GRIN variants in NMDA receptor M2 channel pore‐forming loop are associated with neurological diseases

(2019) Jia Li et al.   HUMAN MUTATION

Goldilocks Zone of Ictal Onset: Partially Recovered Synapses Provide the Kindling to Fuel Ictal Activity

(2019) Deepak Subramanian et al.   Epilepsy Currents

Putting a Band-Aid on a Broken Leg: Antiseizure Medications Are Inferior to Immune Therapies in Autoimmune Epilepsy

(2019) Nicolas Gaspard   Epilepsy Currents

Differential expression of miR-34a, 451, 1260, 1275 and 1298 in the neocortex of patients with mesial temporal lobe epilepsy

(2019) Diana Organista-Juárez et al.   EPILEPSY RESEARCH

Artificial intelligence as an emerging technology in the current care of neurological disorders

(2019) Urvish K. Patel et al.   JOURNAL OF NEUROLOGY

Predictive value of high titer of GAD65 antibodies in a case of limbic encephalitis

(2019) Roberta Di Giacomo et al.   JOURNAL OF NEUROIMMUNOLOGY

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet

(2018) Christine A. Olson et al.   CELL

Deep brain stimulation for epilepsy

(2018) Vicenta Salanova   EPILEPSY & BEHAVIOR

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial

(2018) Elizabeth A Thiele et al.   LANCET

Elevation of MMP-9 Levels Promotes Epileptogenesis After Traumatic Brain Injury

(2018) Barbara Pijet et al.   MOLECULAR NEUROBIOLOGY

Gene therapy and editing: Novel potential treatments for neuronal channelopathies

(2018) R.C. Wykes et al.   NEUROPHARMACOLOGY

Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity

(2018) Daniel Poppe et al.   Stem Cells Translational Medicine

Estrogen Protects Neurotransmission Transcriptome During Status Epilepticus

(2018) Dumitru A. Iacobas et al.   Frontiers in Neuroscience

Preclinical Animal Models for Dravet Syndrome: Seizure Phenotypes, Comorbidities and Drug Screening

(2018) Aliesha Griffin et al.   Frontiers in Pharmacology

Circadian and circaseptan rhythms in human epilepsy: a retrospective cohort study

(2018) Philippa J Karoly et al.   LANCET NEUROLOGY

Prolonged life of human acute hippocampal slices from temporal lobe epilepsy surgery

(2018) J. Wickham et al.   Scientific Reports

Evolving Mechanistic Concepts Of Epileptiform Synchronization And Their Relevance In Curing Focal Epileptic Disorders

(2018) Maxime Lévesque et al.   Current Neuropharmacology

Gene expression profiling in a mouse model of Dravet syndrome

(2018) Nicole A. Hawkins et al.   EXPERIMENTAL NEUROLOGY

Emerging drugs for the treatment of Dravet syndrome

(2018) Francesco Brigo et al.   EXPERT OPINION ON EMERGING DRUGS

The COX-2/prostanoid signaling cascades in seizure disorders

(2018) Asheebo Rojas et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A Proposed Mechanism for Spontaneous Transitions between Interictal and Ictal Activity

(2018) Theju Jacob et al.   JOURNAL OF NEUROSCIENCE

Seizure outcomes in patients with anti-NMDAR encephalitis: A follow-up study

(2017) Xu Liu et al.   EPILEPSIA

Neuroinflammatory targets and treatments for epilepsy validated in experimental models

(2017) Eleonora Aronica et al.   EPILEPSIA

A 2017 review of pharmacotherapy for treating focal epilepsy: where are we now and how will treatment develop?

(2017) Andreas Schulze-Bonhage   EXPERT OPINION ON PHARMACOTHERAPY

GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects

(2017) Konrad Platzer et al.   JOURNAL OF MEDICAL GENETICS

Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology

(2017) Kevin K. Ogden et al.   PLoS Genetics

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains

(2016) Sharon A. Swanger et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human brain slices for epilepsy research: Pitfalls, solutions and future challenges

(2016) Roland S.G. Jones et al.   JOURNAL OF NEUROSCIENCE METHODS

GABA and glycine in the developing brain

(2016) Susumu Ito   Journal of Physiological Sciences

Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study

(2016) Jacqueline A French et al.   LANCET

2014 Epilepsy Benchmarks Area III: Improve Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects

(2016) Dennis Dlugos et al.   Epilepsy Currents

DSigDB: drug signatures database for gene set analysis: Fig. 1.

(2015) Minjae Yoo et al.   BIOINFORMATICS

Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial

(2015) Ronit M Pressler et al.   LANCET NEUROLOGY

Bumetanide for neonatal seizures—back from the cotside

(2015) Ronit M. Pressler et al.   Nature Reviews Neurology

Neonatal seizures still lack safe and effective treatment

(2015) Marianne Thoresen et al.   Nature Reviews Neurology

Epileptogenesis

(2015) Asla Pitkänen et al.   Cold Spring Harbor Perspectives in Medicine

Mechanisms of Epileptogenesis in Pediatric Epileptic Syndromes: Rasmussen Encephalitis, Infantile Spasms, and Febrile Infection-related Epilepsy Syndrome (FIRES)

(2014) Carlos A. Pardo et al.   Neurotherapeutics

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment

(2013) Scott C. Baraban et al.   Nature Communications

An Implantable Closedloop Asynchronous Drug Delivery System for the Treatment of Refractory Epilepsy

(2012) M. T. Salam et al.   IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING